_EC 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase. 4 PDB entries  
EC 2.-.-.- Transferases. [17,806 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,812 PDB entries]
EC 2.7.1.- Phosphotransferases with an alcohol group as acceptor. [1,132 PDB entries]
EC 2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase. [4 PDB entries]    
1y19

Pathway: 1-Phosphatidyl-myo-inositol Metabolism
Reaction: Atp + 1-phosphatidyl-1D-myo-inositol 4-phosphate = adp + 1-phosphatidyl- 1D-myo-inositol 4,5-bisphosphate.
 


ATP
+
1-phosphatidyl-1D-myo-inositol 4-phosphate
=
ADP
+
1-phosphatidyl- 1D-myo-inositol 4,5-bisphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Diphosphoinositide kinase. Phosphatidylinositol 4-phosphate kinase. Phosphatidylinositol-4-phosphate 5-kinase. Pip kinase. PtdIns(4)P-5-kinase. Type I pip kinase.
Comments: This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P(2) in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.2.7.1.68

  PDB code Protein
1y19
Structural basis for phosphatidylinositol phosphate kinase type i-gamma binding to talin at focal adhesions
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: forms chimera with talin at the n-terminus. Gene: tln1, tln. Other_details: forms chimera with phosphatidyl inositol kinase type 1 gamma at thE C-terminus
Chains: A, C, E, G, I, K (11 residues)
2h7d
Solution structure of the talin f3 domain in complex with a chimeric beta3 integrin-pip kinase peptide
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: tln1, tln. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: B (34 residues)
2h7e
Solution structure of the talin f3 domain in complex with a chimeric beta3 integrin-pip kinase peptide- minimized average structure
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: tln1, tln. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: B (34 residues)
3h1z
Molecular basis for the association of pipkigamma -p90 with the clathrin adaptor ap-2
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: ap2b1, clapb1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Chain: P (15 residues)