_EC 2.7.1.40 Pyruvate kinase. 74 PDB entries  
EC 2.-.-.- Transferases. [17,806 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,812 PDB entries]
EC 2.7.1.- Phosphotransferases with an alcohol group as acceptor. [1,132 PDB entries]
EC 2.7.1.40 Pyruvate kinase. [74 PDB entries]    
1a3w

Reaction: Atp + pyruvate = adp + phosphoenolpyruvate.
 


ATP
+
pyruvate
=
ADP
+
phosphoenolpyruvate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Phosphoenol transphosphorylase. Phosphoenolpyruvate kinase.
Comments: Utp, gtp, ctp, itp and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 74 PDB entries in enzyme class E.C.2.7.1.40

  PDB code Protein
1a3w
Pyruvate kinase from saccharomyces cerevisiae complexed with mn2+ and k+
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chains: A, B (492 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
1a3x
Pyruvate kinase from saccharomyces cerevisiae complexed with and k+
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chains: A, B (487 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
1a49
Bis mg-atp-k-oxalate complex of pyruvate kinase
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle
Chains: A, B, C, D, E, F, G, H (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group OXL is 71.00% similar to enzyme reactant pyruvate
1a5u
Pyruvate kinase complex with bis mg-atp-na-oxalate
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle
Chains: A, B, C, D, E, F, G, H (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group OXL is 71.00% similar to enzyme reactant pyruvate
1aqf
Pyruvate kinase from rabbit muscle with mg, k, and l- phospholactate
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle
Chains: A, B, C, D, E, F, G, H (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PEQ corresponds to enzyme product Phosphoenolpyruvate
1e0t
R292d mutant of e. Coli pyruvate kinase
Source: Escherichia coli. Organism_taxid: 511693. Strain: bl21. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: B, C, D ( residues)
1e0u
Structure r271l mutant of e. Coli pyruvate kinase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (461 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
1f3w
Recombinant rabbit muscle pyruvate kinase
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, D, E, F, G, H (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PYR corresponds to enzyme reactant pyruvate
1f3x
S402p mutant of rabbit muscle pyruvate kinase
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, E, F, G, H (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PYR corresponds to enzyme reactant pyruvate
1liu
Human erythrocyte pyruvate kinase
Source: Homo sapiens. Human. Expressed in: escherichia coli
Chains: A, C (517 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
1liw
Human erythrocyte pyruvate kinase: thr384met mutant
Source: Homo sapiens. Human. Expressed in: escherichia coli
Chains: A, C (517 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
1lix
Human erythrocyte pyruvate kinase: arg486trp mutant
Source: Homo sapiens. Human. Expressed in: escherichia coli
Chains: A, C, D (517 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
1liy
Human erythrocyte pyruvate kinase: arg479his mutant
Source: Homo sapiens. Human. Expressed in: escherichia coli
Chains: A, B, C, D (506 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PGA is 90.00% similar to enzyme product Phosphoenolpyruvate
1pkl
The structure of leishmania pyruvate kinase
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: mhom/bz/84/bel46. Cellular_location: cytosol. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, H, G (491 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
1pkm
The refined three-dimensional structure of cat muscle (m1) p kinase, at a resolution of 2.6 angstroms
Source: Felis catus. Domestic cat. Organism_taxid: 9685. Tissue: muscle
Chain: A (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
1pkn
Structure of rabbit muscle pyruvate kinase complexed with mn2+, k+, and pyruvate
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986
Chain: A (514 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PYR corresponds to enzyme reactant pyruvate
1pky
Pyruvate kinase from e. Coli in the t-state
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B, C, D (464 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
1pyk
Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 angstroms
Source: Felis catus. Domestic cat. Organism_taxid: 9685
Chain: A (432 residues)
1t5a
Human pyruvate kinase m2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group OXL is 71.43% similar to enzyme reactant pyruvate
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
1zjh
Structure of human muscle pyruvate kinase (pkm2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pkm. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (507 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
2e28
Crystal structure analysis of pyruvate kinase from bacillus stearothermophilus
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (587 residues) CATH domains: 3.20.20.60 2.40.33.10 3.40.1380.20 3.50.30.10
2g50
The location of the allosteric amino acid binding site of mu pyruvate kinase.
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Other_details: muscle isozyme
Chains: C, D, F, G, H ( residues)
Bound ligand:   Het Group PYR corresponds to enzyme reactant pyruvate
2vgb
Human erythrocyte pyruvate kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (517 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group PGA is 50.00% similar to enzyme reactant pyruvate
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
2vgf
Human erythrocyte pyruvate kinase: t384m mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (517 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group PGA is 50.00% similar to enzyme reactant pyruvate
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
2vgg
Human erythrocyte pyruvate kinase: r479h mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (506 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group PGA is 50.00% similar to enzyme reactant pyruvate
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
2vgi
Human erythrocyte pyruvate kinase: r486w mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C (517 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group PGA is 50.00% similar to enzyme reactant pyruvate
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
3bjf
Pyruvate kinase m2 is a phosphotyrosine binding protein
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: B, D ( residues)
Bound ligands:   Het Group OXL is 71.00% similar to enzyme reactant pyruvate
  Het Group FBP is 42.00% similar to enzyme product Phosphoenolpyruvate
3bjt
Pyruvate kinase m2 is a phosphotyrosine binding protein
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: B, C, D ( residues)
Bound ligand:   Het Group OXL is 71.00% similar to enzyme reactant pyruvate
3e0v
Crystal structure of pyruvate kinase from leishmania mexican complex with sulphate ions
Source: Leishmania mexicana. Organism_taxid: 5665. Gene: pyk. Expressed in: escherichia coli.
Chains: A, B, C, D, E, F (494 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group GOL is 71.43% similar to enzyme reactant pyruvate
3e0w
Crystal structure of pyruvate kinase from leishmania mexican
Source: Leishmania mexicana. Organism_taxid: 5665. Gene: pyk. Expressed in: escherichia coli.
Chain: A (485 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
3eoe
Crystal structure of pyruvate kinase from toxoplasma gondii,
Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: pk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (472 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group GOL is 71.43% similar to enzyme reactant pyruvate
3g2g
S437y mutant of human muscle pyruvate kinase, isoform m2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C, D (455 residues) CATH domains: 3.40.1380.20 3.20.20.60
3gg8
Crystal structure of the toxoplasma gondii pyruvate kinase n truncated
Source: Toxoplasma gondii. Organism_taxid: 5811. Gene: 55m00007, pk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (478 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group GOL is 71.43% similar to enzyme reactant pyruvate
3gqy
Activator-bound structure of human pyruvate kinase m2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, D (514 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group TLA is 60.00% similar to enzyme reactant pyruvate
  Het Group FBP is 42.00% similar to enzyme product Phosphoenolpyruvate
3gr4
Activator-bound structure of human pyruvate kinase m2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: C, D ( residues)
Bound ligands:   Het Group TLA is 60.00% similar to enzyme reactant pyruvate
  Het Group ADP is 66.00% similar to enzyme product ADP
  Het Group FBP is 42.00% similar to enzyme product Phosphoenolpyruvate
3h6o
Activator-bound structure of human pyruvate kinase m2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (490 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
3hqn
Apo crystal structure of leishmania mexicana(lmpyk)pyruvate
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: nhom/b2/84/bel46. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A ( residues)
Bound ligand:   Het Group GOL is 71.43% similar to enzyme reactant pyruvate
3hqo
Crystal structures of leishmania mexicana pyruvate kinase (l complex with atp and oxalate
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: nhom/b2/84/bel46. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: K, A, C (491 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group OXL is 71.00% similar to enzyme reactant pyruvate
3hqp
Crystal structure of leishmania mexicana pyruvate kinase (lm complex with atp, oxalate and fructose 2,6 bisphosphate
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: nhom/b2/84/bel46. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, J, L, M, N, O, P (498 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group OXL is 71.43% similar to enzyme reactant pyruvate
  Het Group FDP is 42.86% similar to enzyme product Phosphoenolpyruvate
3hqq
Crystal structure of leishmania mexicana pyruvate kinase (lm complex with fructose 2,6 bisphosphate
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: nhom/b2/84/bel46. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, G, H, I, J, K, M, N, O, Q, S, T, U, V, W, X (498 residues)
Bound ligand:   Het Group FDP is 42.00% similar to enzyme product Phosphoenolpyruvate
3is4
Crystal structure of leishmania mexicana pyruvate kinase (lmpyk)in complex with 1,3,6,8-pyrenetetrasulfonic acid
Source: Leishmania mexicana. Organism_taxid: 5665. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: promastigotes
Chain: A (492 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group GOL is 71.00% similar to enzyme reactant pyruvate
3khd
Crystal structure of pff1300w.
Source: Plasmodium falciparum 3d7. Organism_taxid: 36329. Gene: pff1300w. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (487 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
3ktx
Crystal structure of leishmania mexicana pyruvate kinase (lm complex with 1,3,6,8-pyrenetetrasulfonic acid
Source: Leishmania mexicana. Organism_taxid: 5665. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: B ( residues)
Bound ligand:   Het Group GOL is 71.43% similar to enzyme reactant pyruvate
3ma8
Crystal structure of cgd1_2040, a pyruvate kinase from crypt parvum
Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd1_2040. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (490 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group CIT is 46.00% similar to enzyme reactant pyruvate
3me3
Activator-bound structure of human pyruvate kinase m2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, oip3, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, D (518 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
3n25
The structure of muscle pyruvate kinase in complex with prol pyruvate, and mn2+
Source: Oryctolagus cuniculus. European rabbit,japanese white rabbit,dome rabbit,rabbits. Organism_taxid: 9986. Tissue: muscle
Chains: A, B, C, D, F, H (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PYR corresponds to enzyme reactant pyruvate
3pp7
Crystal structure of leishmania mexicana pyruvate kinase in with the drug suramin, an inhibitor of glycolysis.
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: bel46. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (492 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group GOL is 71.43% similar to enzyme reactant pyruvate
3qtg
Crystal structure of pyruvate kinase from pyrobaculum aeroph
Source: Pyrobaculum aerophilum. Organism_taxid: 178306. Strain: atcc 51768, im2. Gene: pae0819, pyk. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (450 residues) CATH domains: 3.20.20.60 2.40.33.10 3.40.1380.20
3qv6
Crystal structure of leishmania mexicana pyruvate kinase(lmp complex with acid blue 80.
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: bel46. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (493 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product Phosphoenolpyruvate
3qv7
Crystal structure of leishmania mexicana pyruvate kinase(lmp complex with ponceau s and acid blue 25.
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: bel46. Gene: pky. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C ( residues)
3qv8
Crystal structure of leishmania mexicana pyruvate kinase(lmp complex with benzothiazole-2,5-disulfonic acid.
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: bel46. Gene: pky. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: D, A (492 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product Phosphoenolpyruvate
3qv9
Crystal structure of trypanosoma cruzi pyruvate kinase(tcpyk complex with ponceau s.
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: tc00.1047053511281.60. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (499 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product Phosphoenolpyruvate
3srd
Human m2 pyruvate kinase in complex with fructose 1-6 bispho oxalate.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (515 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group OXL is 71.43% similar to enzyme reactant pyruvate
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
3srf
Human m1 pyruvate kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm1, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: C, A, B, D, E, G (517 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PYR corresponds to enzyme reactant pyruvate
3srh
Human m2 pyruvate kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, D (518 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product Phosphoenolpyruvate
3srk
A new class of suicide inhibitor blocks nucleotide binding t kinase
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: mhom/bz/84/bel46. Gene: pyk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (493 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
3t05
Crystal structure of s. Aureus pyruvate kinase
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 282458. Strain: mrsa252. Gene: pyk, sar1776. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (583 residues) CATH domains: 3.20.20.60 2.40.33.10 3.40.1380.20 3.50.30.10
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product Phosphoenolpyruvate
3t07
Crystal structure of s. Aureus pyruvate kinase in complex wi naturally occurring bis-indole alkaloid
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 282458. Strain: mrsa252. Gene: pyk, sar1776. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (583 residues) CATH domains: 3.20.20.60 2.40.33.10 3.40.1380.20 3.50.30.10
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product Phosphoenolpyruvate
3t0t
Crystal structure of s. Aureus pyruvate kinase
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 282458. Strain: mrsa252. Gene: pyk, sar1776. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: B, C, D ( residues)
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product Phosphoenolpyruvate
3u2z
Activator-bound structure of human pyruvate kinase m2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, oip3, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (519 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
4b2d
Human pkm2 with l-serine and fbp bound.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (518 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group SER is 62.50% similar to enzyme reactant pyruvate
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
4drs
Crystal structure of cryptosporidium parvum pyruvate kinase
Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd1_2040. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (485 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group GOL is 71.43% similar to enzyme reactant pyruvate
4fxf
Structure of m2 pyruvate kinase in complex with phenylalanin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm2, pyruvate kinase m2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, D, C, B (501 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group OXL is 71.43% similar to enzyme reactant pyruvate
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
4fxj
Structure of m2 pyruvate kinase in complex with phenylalanin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm2, pyruvate kinase m2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (498 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligand:   Het Group PO4 is 50.00% similar to enzyme product Phosphoenolpyruvate
4g1n
Pkm2 in complex with an activator
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, oip3, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (518 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligand:   Het Group OXL is 71.43% similar to enzyme reactant pyruvate
4hyv
Pyruvate kinase (pyk) from trypanosoma brucei in the presenc magnesium, pep and f26bp
Source: Trypanosoma brucei brucei. Organism_taxid: 5702. Gene: pyk1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (498 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligand:   Het Group PEP corresponds to enzyme product Phosphoenolpyruvate
4hyw
Pyruvate kinase (pyk) from trypanosoma brucei in the presenc magnesium and f26bp
Source: Trypanosoma brucei brucei. Organism_taxid: 5702. Gene: pyk1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: B, A (498 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligands:   Het Group GOL is 71.43% similar to enzyme reactant pyruvate
  Het Group FDP is 42.86% similar to enzyme product Phosphoenolpyruvate
4ima
The structure of c436m-hlpyk in complex with citrate/mn/atp/
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (522 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group FLC is 46.15% similar to enzyme reactant pyruvate
  Het Group ADN is 70.37% similar to enzyme product ADP
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
4ip7
Structure of the s12d variant of human liver pyruvate kinase complex with citrate and fbp.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pk1, pkl, pklr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (506 residues) CATH domains: 3.40.1380.20 3.20.20.60 2.40.33.10
Bound ligands:   Het Group FLC is 46.15% similar to enzyme reactant pyruvate
  Het Group ADN is 70.37% similar to enzyme product ADP
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
4jpg
2-((1h-benzo[d]imidazol-1-yl)methyl)-4h-pyrido[1,2-a]pyrimid as novel pkm2 activators
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (519 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligands:   Het Group 1OX is 41.18% similar to enzyme product ADP
  Het Group FBP is 42.86% similar to enzyme product Phosphoenolpyruvate
4kct
Pyruvate kinase (pyk) from trypanosoma brucei soaked with ox
Source: Trypanosoma brucei brucei. Organism_taxid: 5702. Gene: pyk1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: B, A (498 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligands:   Het Group PYR corresponds to enzyme reactant pyruvate
  Het Group FDP is 42.86% similar to enzyme product Phosphoenolpyruvate
4kcu
Pyruvate kinase (pyk) from trypanosoma brucei soaked with d-
Source: Trypanosoma brucei brucei. Organism_taxid: 5702. Gene: pyk1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (498 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligands:   Het Group MLT is 66.67% similar to enzyme reactant pyruvate
  Het Group FDP is 42.86% similar to enzyme product Phosphoenolpyruvate
4kcv
Pyruvate kinase (pyk) from trypanosoma brucei soaked with 2- oxoglutaric acid
Source: Trypanosoma brucei brucei. Organism_taxid: 5702. Gene: pyk1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: B, A (498 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligands:   Het Group AKG is 60.00% similar to enzyme reactant pyruvate
  Het Group FDP is 42.86% similar to enzyme product Phosphoenolpyruvate
4kcw
Pyruvate kinase (pyk) from trypanosoma brucei soaked with ox
Source: Trypanosoma brucei brucei. Organism_taxid: 5702. Gene: pyk1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (498 residues) CATH domains: 3.40.1380.20 3.20.20.60
Bound ligands:   Het Group OXL is 71.43% similar to enzyme reactant pyruvate
  Het Group FDP is 42.86% similar to enzyme product Phosphoenolpyruvate