_EC 2.7.1.33 Pantothenate kinase. 54 PDB entries  
EC 2.-.-.- Transferases. [17,952 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,912 PDB entries]
EC 2.7.1.- Phosphotransferases with an alcohol group as acceptor. [1,127 PDB entries]
EC 2.7.1.33 Pantothenate kinase. [54 PDB entries]    
1esm

Pathway: Coenzyme A Biosynthesis (late stages)
Reaction: Atp + (R)-pantothenate = adp + (R)-4'-phosphopantothenate.
 


ATP
+
(R)-pantothenate
=
ADP
+
(R)-4'-phosphopantothenate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): ATP:pantothenate 4'-phosphotransferase. D-pantothenate kinase. Pantothenate kinase (phosphorylating). Pantothenic acid kinase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 54 PDB entries in enzyme class E.C.2.7.1.33

  PDB code Protein
1esm
Structural basis for the feedback regulation of escherichia coli pantothenate kinase by coenzyme a
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (311 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group COA is 56.00% similar to enzyme product ADP
1esn
Structural basis for the feedback regulation of escherichia coli pantothenate kinase by coenzyme a
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (311 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1sq5
Crystal structure of e. Coli pantothenate kinase
Source: Escherichia coli. Organism_taxid: 562. Gene: coaa, rts, pank, b3974, c4933, z5545, ecs4901. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (302 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
  Het Group ADP corresponds to enzyme product ADP
2ews
Crystal structure of s.Aureus pantothenate kinase
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 282459. Strain: mssa476. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (260 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
2f9t
Structure of the type iii coaa from pseudomonas aeruginosa
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: pao1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (241 residues) CATH domain: 3.30.420.40
2f9w
Structure of the type iii coaa from pseudomonas aeruginosa
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: pao1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (249 residues) CATH domain: 3.30.420.40
Bound ligand:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
2ges
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with a coenzyme a derivative, form-i (rt)
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa(rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (308 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group COK is 51.92% similar to enzyme product ADP
2get
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with a coenzyme a derivative, form-i (lt)
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa(rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (308 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group COK is 51.92% similar to enzyme product ADP
2geu
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with a coenzyme a derivative, form-ii (rt)
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa(rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (305 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group COK is 51.92% similar to enzyme product ADP
2gev
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with a coenzyme a derivative, form-ii (lt)
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa(rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (308 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group COK is 51.92% similar to enzyme product ADP
2gtd
Crystal structure of a type iii pantothenate kinase: insight into the catalysis of an essential coenzyme a biosynthetic enzyme universally distributed in bacteria
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (248 residues) CATH domain: 3.30.420.40
2h3g
Structure of the type iii pantothenate kinase (coax) from ba anthracis
Source: Bacillus anthracis str.. Organism_taxid: 198094. Strain: ames. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (247 residues) CATH domains: Unassigned 3.30.420.40
2i7n
Crystal structure of human pank1 alpha: the catalytic core domain in complex with accoa
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pank1, pank. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (325 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligand:   Het Group ACO is 60.00% similar to enzyme product (R)-4'-phosphopantothenate
2i7p
Crystal structure of human pank3 in complex with accoa
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pank3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (353 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligand:   Het Group ACO is 60.00% similar to enzyme product (R)-4'-phosphopantothenate
2nrh
Crystal structure of conserved putative baf family transcrip activator from campylobacter jejuni
Source: Campylobacter jejuni. Organism_taxid: 197. Gene: cje0443. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (192 residues) CATH domains: 3.30.420.40 3.30.420.40
2zs7
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with citrate anion
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa (rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (307 residues) CATH domain: 3.40.50.300
2zs8
Pantothenate kinase from mycobacterium tuberculosis (mtpank) crystallized with adp
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa (rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2zs9
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with adp and pantothenate
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa (rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
  Het Group ADP corresponds to enzyme product ADP
2zsa
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with adp and phosphopantothenate
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa (rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group PAZ corresponds to enzyme product (R)-4'-phosphopantothenate
2zsb
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with adp, obtained through soaking of native enzyme with the ligand
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa (rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2zsd
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with coenzyme a
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa (rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group COA is 56.25% similar to enzyme product ADP
2zse
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with amppcp and pantothenate
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa (rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
  Het Group ACP is 81.25% similar to enzyme product ADP
2zsf
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with atp and adp
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa (rv1092c). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3aez
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with gdp and phosphopantothenate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group GDP is 96.43% similar to enzyme product ADP
  Het Group PAZ corresponds to enzyme product (R)-4'-phosphopantothenate
3af0
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with gdp and pantothenate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
  Het Group GDP is 96.43% similar to enzyme product ADP
3af1
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with gdp
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group GDP is 96.43% similar to enzyme product ADP
3af2
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with amppcp
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ACP is 81.25% similar to enzyme product ADP
3af3
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with gmppcp and pantothenate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
  Het Group GCP is 78.79% similar to enzyme product ADP
3af4
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with gmppcp
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group GCP is 78.79% similar to enzyme product ADP
3avo
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with pantothenate
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
3avp
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with pantothenol
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group MV2 is 93.33% similar to enzyme reactant (R)-pantothenate
3avq
Pantothenate kinase from mycobacterium tuberculosis (mtpank) complex with n9-pan
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: coaa, rv1092c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group MV1 is 56.00% similar to enzyme reactant (R)-pantothenate
3bex
Type iii pantothenate kinase from thermotoga maritima complexed with pantothenate
Source: Thermotoga maritima. Gene: coax. Expressed in: escherichia coli.
Chains: A, B, C, D, E, F (248 residues) CATH domain: 3.30.420.40
Bound ligand:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
3bf1
Type iii pantothenate kinase from thermotoga maritima complexed with pantothenate and adp
Source: Thermotoga maritima. Gene: coax. Expressed in: escherichia coli.
Chains: A, B, C, D, E, F (248 residues) CATH domain: 3.30.420.40
Bound ligands:   Het Group PAU corresponds to enzyme reactant (R)-pantothenate
  Het Group ADP corresponds to enzyme product ADP
3bf3
Type iii pantothenate kinase from thermotoga maritima complexed with product phosphopantothenate
Source: Thermotoga maritima. Gene: coax. Expressed in: escherichia coli.
Chains: A, B, C, D, E, F (248 residues) CATH domain: 3.30.420.40
Bound ligand:   Het Group PAZ corresponds to enzyme product (R)-4'-phosphopantothenate
3djc
Crystal structure of pantothenate kinase from legionella pne
Source: Legionella pneumophila subsp. Pneumoph philadelphia 1. Organism_taxid: 272624. Gene: coax, lpg0911
Chains: A, B, C, D, E, F, G, H, I, J, K, L (255 residues) CATH domains: Unassigned 3.30.420.40
3mk6
Substrate and inhibitor binding to pank
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pank3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (354 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligand:   Het Group ACO is 52.00% similar to enzyme product ADP
3smp
Monoclinic crystal structure of human pantothenate kinase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pank1, pank. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (358 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligand:   Het Group ACO is 52.94% similar to enzyme product ADP
3sms
Human pantothenate kinase 3 in complex with a pantothenate a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pank3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (351 residues) CATH domains: Unassigned Unassigned Unassigned
Bound ligands:   Het Group RNH is 60.87% similar to enzyme reactant (R)-pantothenate
  Het Group ADP corresponds to enzyme product ADP
3tqc
Structure of the pantothenate kinase (coaa) from coxiella bu
Source: Coxiella burnetii. Organism_taxid: 777. Strain: rsa 493 nine mile phase i. Gene: cbu_0199, coaa. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (303 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
4bfs
Crystal structure of mycobacterium tuberculosis pank in complex with a triazole inhibitory compound (1a)
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (302 residues) CATH domain: 3.40.50.300
4bft
Crystal structure of mycobacterium tuberculosis pank in complex with a triazole inhibitory compound (1b) and phosphate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (306 residues) CATH domain: 3.40.50.300
4bfu
Crystal structure of mycobacterium tuberculosis pank in complex with a triazole inhibitory compound (1c) and phosphate
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (306 residues) CATH domain: 3.40.50.300
4bfv
Crystal structure of mycobacterium tuberculosis pank in complex with a triazole inhibitory compound (1d) and phosph
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (306 residues) CATH domain: 3.40.50.300
4bfw
Crystal structure of mycobacterium tuberculosis pank in complex with a triazole inhibitory compound (1e) and phosph
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (306 residues) CATH domain: 3.40.50.300
4bfx
Crystal structure of mycobacterium tuberculosis pank in complex with a triazole inhibitory compound (1f) and phosph
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (306 residues) CATH domain: 3.40.50.300
4bfy
Crystal structure of mycobacterium tuberculosis pank in complex with a biaryl inhibitory compound (2a) and phosphat
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (306 residues) CATH domain: 3.40.50.300
4bfz
Crystal structure of mycobacterium tuberculosis pank in complex with a biaryl inhibitory compound (2b) and phosphat
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (306 residues) CATH domain: 3.40.50.300
4f7w
Crystal structure of klebsiella pneumoniae pantothenate kina complex with n-pentylpantothenamide
Source: Klebsiella pneumoniae. Organism_taxid: 507522. Strain: 342. Gene: coaa, kpk_5321. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D, E, F, G, H (309 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group PN4 is 66.67% similar to enzyme reactant (R)-pantothenate
  Het Group ADP corresponds to enzyme product ADP
4gi7
Crystal structure of klebsiella pneumoniae pantothenate kina complex with a pantothenate analogue
Source: Klebsiella pneumoniae. Organism_taxid: 507522. Strain: 342. Gene: coaa, kpk_5321. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D, E, F, G, H (309 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group 0JR is 60.87% similar to enzyme reactant (R)-pantothenate
  Het Group ADP corresponds to enzyme product ADP
4nb4
Pantothenamide-bound pantothenate kinase from staphylococcus
Source: Staphylococcus aureus. Organism_taxid: 282458. Strain: mssa476. Gene: coaa, coaw. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (265 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group SH3 is 58.06% similar to enzyme product (R)-4'-phosphopantothenate
4ne2
Pantothenamide-bound pantothenate kinase from klebsiella pne
Source: Klebsiella pneumoniae. Organism_taxid: 507522. Strain: 342. Gene: coaa, kpk_5321, uuu_44690. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (304 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group SH2 is 51.85% similar to enzyme reactant (R)-pantothenate
  Het Group ADP corresponds to enzyme product ADP
4o5f
Crystal structure of type iii pantothenate kinase from burkh thailandensis in complex with pantothenate and phosphate
Source: Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264. Gene: bth_i0369, coax. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (258 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group ATP is 41.94% similar to enzyme reactant ATP
  Het Group PAU corresponds to enzyme reactant (R)-pantothenate
4o8k
Crystal structure of type iii pantothenate kinase from burkh thailandensis, apo structure
Source: Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264. Gene: bth_i0369, coax. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (257 residues) CATH domains: Unassigned Unassigned