_EC 2.7.1.26 Riboflavin kinase. 17 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,916 PDB entries]
EC 2.7.1.- Phosphotransferases with an alcohol group as acceptor. [1,130 PDB entries]
EC 2.7.1.26 Riboflavin kinase. [17 PDB entries]    
1mrz

Reaction: Atp + riboflavin = adp + fmn.
 


ATP
+
riboflavin
=
ADP
+
FMN
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Flavokinase. Rfk.
Cofactor(s): Mg(2+) or Zn(2+) or Mn(2+).
Comments: The cofactors Fmn and fad participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B(6), vitamin B12 and folates. While monofunctional riboflavin kinase is found in eukaryotes, some bacteria have a bifunctional enzyme that exhibits both this activity and that of Ec 2.7.7.2. In Bacillus subtilis, Atp can be replaced by other phosphate donors but with decreasing enzyme activity in the order Atp > dATP > ctp > Utp.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 17 PDB entries in enzyme class E.C.2.7.1.26

  PDB code Protein
1mrz
Crystal structure of a flavin binding protein from thermotog maritima, tm379
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm379. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (266 residues) CATH domains: 3.40.50.620 2.40.30.30
1n05
Crystal structure of schizosaccharomyces pombe riboflavin kinase reveals a novel atp and riboflavin binding fold
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: spcc18.16c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (142 residues) CATH domain: 2.40.30.30
1n06
Crystal structure of schizosaccharomyces pombe riboflavin kinase reveals a novel atp and riboflavin binding fold
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: spcc18.16.C. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (154 residues) CATH domain: 2.40.30.30
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1n07
Crystal structure of schizosaccharomyces pombe riboflavin kinase reveals a novel atp and riboflavin binding fold
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: spcc18.16c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (154 residues) CATH domain: 2.40.30.30
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group FMN corresponds to enzyme product FMN
1n08
Crystal structure of schizosaccharomyces pombe riboflavin kinase reveals a novel atp and riboflavin binding fold
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: spcc18.16c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (154 residues) CATH domain: 2.40.30.30
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1nb0
Crystal structure of human riboflavin kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: brain. Gene: flj11149. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (147 residues) CATH domain: 2.40.30.30
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1nb9
Crystal structure of riboflavin kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flj11149. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (147 residues) CATH domain: 2.40.30.30
Bound ligands:   Het Group RBF corresponds to enzyme reactant riboflavin
  Het Group ADP corresponds to enzyme product ADP
1nbg
Crystal structure of riboflavin kinase
Source: Homo sapiens. Human. Gene: flj11149. Expressed in: escherichia coli.
Chain: A (147 residues) CATH domain: 2.40.30.30
Bound ligands:   Het Group ADP is 87.00% similar to enzyme reactant ATP
  Het Group FMN is 81.00% similar to enzyme reactant riboflavin
1p4m
Crystal structure of riboflavin kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flj11149. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (147 residues) CATH domain: 2.40.30.30
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group FMN corresponds to enzyme product FMN
1q9s
Crystal structure of riboflavin kinase with ternary product complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flj11149. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (149 residues) CATH domain: 2.40.30.30
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group FMN corresponds to enzyme product FMN
1s4m
Crystal structure of flavin binding to fad synthetase from thermotoga maritina
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (277 residues) CATH domains: 3.40.50.620 2.40.30.30
1t6x
Crystal structure of adp bound tm379
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (266 residues) CATH domains: 3.40.50.620 2.40.30.30
1t6y
Crystal structure of adp, amp, and fmn bound tm379
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (268 residues) CATH domains: 3.40.50.620 2.40.30.30
1t6z
Crystal structure of riboflavin bound tm379
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (266 residues) CATH domains: 3.40.50.620 2.40.30.30
2i1l
Crystal structure of the c2 form of fad synthetase from thermotoga maritima
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm_0857. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (267 residues) CATH domains: 3.40.50.620 2.40.30.30
2x0k
Crystal structure of modular fad synthetase from corynebacterium ammoniagenes
Source: Corynebacterium ammoniagenes. Organism_taxid: 1697. Atcc: 6872. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (338 residues) CATH domains: 3.40.50.620 2.40.30.30
3zug
E268d mutant of fad synthetase from corynebacterium ammoniag
Source: Corynebacterium ammoniagenes. Organism_taxid: 1697. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (335 residues) CATH domains: 3.40.50.620 2.40.30.30