_EC 2.7.1.25 Adenylyl-sulfate kinase. 19 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,916 PDB entries]
EC 2.7.1.- Phosphotransferases with an alcohol group as acceptor. [1,130 PDB entries]
EC 2.7.1.25 Adenylyl-sulfate kinase. [19 PDB entries]    
1d6j

Reaction: Atp + adenylyl sulfate = adp + 3'-phosphoadenylyl sulfate.
 


ATP
+
adenylyl sulfate
=
ADP
+
3'-phosphoadenylyl sulfate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Adenosine 5'-phosphosulfate kinase. Adenylylsulfate kinase. Aps kinase.
Comments: The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: Atp sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from Atp and inorganic sulfate and the second step is catalyzed by the Aps kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of Paps from enzyme bound aps and atp. This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of Paps is carried out by two individual polypeptides, Ec 2.7.7.4 and Ec 2.7.1.25.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 19 PDB entries in enzyme class E.C.2.7.1.25

  PDB code Protein
1d6j
Crystal structure of adenosine 5'-phosphosulfate (aps) kinase from penicillium chrysogenum
Source: Penicillium chrysogenum. Organism_taxid: 5076. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (177 residues) CATH domain: 3.40.50.300
1m7g
Crystal structure of aps kinase from penicillium chrysogenum structure with adp and aps
Source: Penicillium chrysogenum. Organism_taxid: 5076. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (208 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group ADX corresponds to enzyme reactant adenylyl
  Het Group AV2 is 90.00% similar to enzyme product ADP
1m7h
Crystal structure of aps kinase from penicillium chrysogenum: structure with aps soaked out of one dimer
Source: Penicillium chrysogenum. Organism_taxid: 5076. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (203 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group ADX corresponds to enzyme reactant adenylyl sulfate
  Het Group ADP corresponds to enzyme product ADP
1x6v
The crystal structure of human 3'-phosphoadenosine-5'-phosph synthetase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss1, papss, atpsk1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: B, A (586 residues) CATH domains: 3.40.50.300 3.10.400.10 3.40.50.620
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1xjq
Adp complex of human paps synthetase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss1, papss, atpsk1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: B, A (590 residues) CATH domains: 3.40.50.300 3.10.400.10 3.40.50.620
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1xnj
Aps complex of human paps synthetase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss1, papss, atpsk1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: B, A (590 residues) CATH domains: 3.40.50.300 3.10.400.10 3.40.50.620
Bound ligands:   Het Group ADX corresponds to enzyme reactant adenylyl
  Het Group ADP corresponds to enzyme product ADP
2ax4
Crystal structure of the kinase domain of human 3'- phosphoadenosine 5'-phosphosulphate synthetase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (198 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2gks
Crystal structure of the bi-functional atp sulfurylase-aps k aquifex aeolicus, a chemolithotrophic thermophile
Source: Aquifex aeolicus. Organism_taxid: 63363. Gene: sat/cysc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (522 residues) CATH domains: 3.10.400.10 3.40.50.620 3.40.50.300
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2ofw
Crystal structure of the apsk domain of human papss1 complexed with 2 aps molecules
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss1, atpsk1, papss. Expressed in: escherichia coli. Expression_system_taxid: 562. Cutting site
Chains: A, B, C, D, E, F, G, H (200 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ADX corresponds to enzyme reactant adenylyl sulfate
2ofx
Crystal structure of the apsk domain of human papss1 in complex with adpmg and paps
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss1. Expressed in: escherichia coli. Expression_system_taxid: 562. Cutting site
Chains: A, B (205 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group PPS corresponds to enzyme product 3'-phosphoadenylyl sulfate
2pey
Crystal strucutre of deletion mutant of aps-kinase domain of human paps-synthetase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss1, atpsk1, papss. Expressed in: escherichia coli. Expression_system_taxid: 562. Site was replaced by tev cutting site
Chains: A, B (176 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group ADX corresponds to enzyme reactant adenylyl sulfate
  Het Group DAT is 96.00% similar to enzyme product ADP
2pez
Crystal structrue of deletion mutant of aps-kinase domain of human paps-synthetase 1 in complex with cyclic paps and dadp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss1, atpsk1, papss. Expressed in: escherichia coli. Expression_system_taxid: 562. Clevage site was replaced by tev site
Chains: A, B (176 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group GGZ is 90.00% similar to enzyme reactant adenylyl sulfate
  Het Group DAT is 96.00% similar to enzyme product ADP
2qjf
Crystal structure of atp-sulfurylase domain of human paps synthetase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: papss1, atpsk1, papss. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (390 residues) CATH domains: 3.10.400.10 3.40.50.620
Bound ligand:   Het Group ADX corresponds to enzyme reactant adenylyl sulfate
2yvu
Crystal structure of ape1195
Source: Aeropyrum pernix. Organism_taxid: 272557. Strain: k1. Gene: cysc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (179 residues) CATH domain: 3.40.50.300
3cr7
Crystal structure of n-terminal truncation of aps kinase from penicillium chrysogenum: ternary structure with adp and paps
Source: Penicillium chrysogenum. Penicillium notatum. Organism_taxid: 5076. Strain: attc 24791. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (179 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group PPS corresponds to enzyme product 3'-phosphoadenylyl sulfate
3cr8
Hexameric aps kinase from thiobacillus denitrificans
Source: Thiobacillus denitrificans. Strain atcc 25259. Organism_taxid: 36861. Strain: atcc 25259. Expressed in: escherichia coli. Expression_system_taxid: 292415.
Chains: A, B, C (493 residues) CATH domains: 3.10.400.10 3.40.50.620 3.40.50.300
3uie
Crystal structure of adenosine 5'-phosphosulfate kinase from arabidopsis thaliana in complex with amppnp and aps
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: akn1, at2g14750, f26c24.11, t6b13.1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (191 residues) CATH domain: 3.40.50.300
Bound ligands:   Het Group ADX corresponds to enzyme reactant adenylyl
  Het Group ANP is 81.25% similar to enzyme product ADP
4bzq
Structure of the mycobacterium tuberculosis aps kinase cysc in complex with adp and aps
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (173 residues)
4fxp
Crystal structure of adenosine 5'-phosphosulfate kinase from arabidopsis thaliana in complex with sulfate and aps
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: akn1, at2g14750, f26c24.11, t6b13.1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (192 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ADX corresponds to enzyme reactant adenylyl