_EC 2.7.1.2 Glucokinase. 21 PDB entries  
EC 2.-.-.- Transferases. [15,100 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [9,112 PDB entries]
EC 2.7.1.- Phosphotransferases with an alcohol group as acceptor. [954 PDB entries]
EC 2.7.1.2 Glucokinase. [21 PDB entries]    
1q18

Reaction: Atp + D-glucose = adp + D-glucose 6-phosphate.
 


ATP
+
D-glucose
=
ADP
+
D-glucose 6-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glucose kinase.
Comments: A group of enzymes found in invertebrates and microorganisms highly specific for glucose.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 21 PDB entries in enzyme class E.C.2.7.1.2

  PDB code Protein
1q18
Crystal structure of e.Coli glucokinase (glk)
Source: Escherichia coli. Organism_taxid: 562. Gene: glk or b2388 or z3654 or ecs3268. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (320 residues) CATH domains: 3.30.420.40 3.40.367.20
1sz2
Crystal structure of e. Coli glucokinase in complex with glucose
Source: Escherichia coli. Organism_taxid: 562. Gene: glk, b2388, z3654, ecs3268. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (319 residues) CATH domains: 3.30.420.40 3.40.367.20
Bound ligand:   Het Group BGC corresponds to enzyme reactant D-glucose
1v4s
Crystal structure of human glucokinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (448 residues) CATH domains: 3.40.367.20 3.30.420.40
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
1v4t
Crystal structure of human glucokinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (424 residues) CATH domains: 3.40.367.20 3.30.420.40
2q2r
Trypanosoma cruzi glucokinase in complex with beta-d-glucose
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: tc00.1047053510187.100. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (370 residues) CATH domains: Unassigned 3.40.367.20
Bound ligands:   Het Group BGC corresponds to enzyme reactant D-glucose
  Het Group ADP corresponds to enzyme product ADP
3fgu
Catalytic complex of human glucokinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (447 residues) CATH domains: 3.40.367.20 3.30.420.40
Bound ligands:   Het Group BGC corresponds to enzyme reactant D-glucose
  Het Group ANP is 81.25% similar to enzyme product ADP
3fr0
Human glucokinase in complex with 2-amino benzamide activator
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (448 residues) CATH domains: 3.40.367.20 3.30.420.40
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
3idh
Human pancreatic glucokinase in complex with glucose
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (453 residues) CATH domains: 3.40.367.20 3.30.420.40
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
3imx
Crystal structure of human glucokinase in complex with a synthetic activator
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck, hcg_1745191, tcag7.801. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (447 residues) CATH domains: 3.40.367.20 3.30.420.40
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
3s41
Glucokinase in complex with activator and glucose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (448 residues) CATH domains: 3.40.367.20 3.30.420.40
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
3vey
Glucokinase in complex with glucose and atpgs
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (448 residues) CATH domains: 3.40.367.20 3.30.420.40
Bound ligands:   Het Group AGS is 93.75% similar to enzyme reactant ATP
  Het Group GLC corresponds to enzyme reactant D-glucose
4dch
Insights into glucokinase activation mechanism: observation multiple distinct protein conformations
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (434 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4dhy
Crystal structure of human glucokinase in complex with gluco activator
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (448 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4ise
Human glucokinase in complex with novel activator (2s)-3-cyc (6-fluoro-4-oxoquinazolin-3(4h)-yl)-n-(1,3-thiazol-2-yl)pro
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck, hxk4 isoform ii. Expressed in: escherichia coli. Expression_system_taxid: 668369.
Chain: A (427 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4isf
Human glucokinase in complex with novel activator (2s)-3-cyc (6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2h)-yl)-n-(1,3- yl)propanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck, hxk4 isoform ii. Expressed in: escherichia coli. Expression_system_taxid: 668369.
Chain: A (428 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4isg
Human glucokinase in complex with novel activator (2s)-3-cyc [4-(methylsulfonyl)-2-oxopiperazin-1-yl]-n-(1,3-thiazol-2-y propanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck, hxk4 isoform ii. Expressed in: escherichia coli. Expression_system_taxid: 668369.
Chain: A (418 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4ixc
Crystal structure of human glucokinase in complex with a sma molecule activator.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (443 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4l3q
Crystal structure of glucokinase-activator complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (447 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4mle
Human glucokinase in complex with novel amino thiazole activ
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (448 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4no7
Human glucokinase in complex with a nanomolar activator.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (446 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose
4rch
Discovery of 2-pyridyl ureas as glucokinase activators
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (448 residues) CATH domain: 3.40.367.20
Bound ligand:   Het Group GLC corresponds to enzyme reactant D-glucose