_EC 2.7.1.154 Phosphatidylinositol-4-phosphate 3-kinase. 6 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,910 PDB entries]
EC 2.7.1.- Phosphotransferases with an alcohol group as acceptor. [1,129 PDB entries]
EC 2.7.1.154 Phosphatidylinositol-4-phosphate 3-kinase. [6 PDB entries]    
2ar5

Pathway: 1-Phosphatidyl-myo-inositol Metabolism
Reaction: Atp + 1-phosphatidyl-1D-myo-inositol 4-phosphate = adp + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate.
 


ATP
+
1-phosphatidyl-1D-myo-inositol 4-phosphate
=
ADP
+
1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): C2-domain-containing phosphoinositide 3-kinase. Phosphoinositide 3-kinase. Type Ii phosphoinositide 3-kinase.
Comments: This enzyme also phosphorylates PtdIns to PtdIns3P.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.2.7.1.154

  PDB code Protein
2ar5
Crystal structure of the mammalian c2alpha-pi3 kinase px-dom
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pi3kc2a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (117 residues) CATH domain: 3.30.1520.10
2b3r
Crystal structure of the c2 domain of class ii phosphatidyli 3-kinase c2
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: pik3c2a, cpk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (124 residues) CATH domain: 2.60.40.150
2iwl
Structure of the px domain of phosphoinositide 3-kinase- c2alpha
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (121 residues) CATH domain: 3.30.1520.10
2rea
Crystal structures of c2alpha-pi3 kinase px-domain domain indicate conformational change associated with ligand binding.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3c2a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (116 residues) CATH domain: 3.30.1520.10
2red
Crystal structures of c2alpha-pi3 kinase px-domain domain in conformational change associated with ligand binding.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3c2a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (114 residues) CATH domain: 3.30.1520.10
2wwe
Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-c2-gamma
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3 prare.
Chain: A (111 residues) CATH domain: 3.30.1520.10