_EC 2.7.1.11 6-phosphofructokinase. 25 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,916 PDB entries]
EC 2.7.1.- Phosphotransferases with an alcohol group as acceptor. [1,130 PDB entries]
EC 2.7.1.11 6-phosphofructokinase. [25 PDB entries]    
1mto

Reaction: Atp + D-fructose 6-phosphate = adp + D-fructose 1,6-bisphosphate.
 


ATP
+
D-fructose 6-phosphate
=
ADP
+
D-fructose 1,6-bisphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Phosphofructokinase I. Phosphohexokinase.
Comments: D-tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. Utp, ctp and itp can act as donors. Not identical with Ec 2.7.1.105.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 25 PDB entries in enzyme class E.C.2.7.1.11

  PDB code Protein
1mto
Crystal structure of a phosphofructokinase mutant from bacillus stearothermophilus bound with fructose-6-phosphate
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: pfk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (319 residues) CATH domains: 3.40.50.450 3.40.50.460
Bound ligand:   Het Group F6P corresponds to enzyme reactant D-fructose 6-phosphate
1pfk
Crystal structure of the complex of phosphofructokinase from escherichia coli with its reaction products
Source: Escherichia coli. Organism_taxid: 562. Cell_line: 293.
Chains: A, B (320 residues) CATH domains: 3.40.50.450 3.40.50.460
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group FBP corresponds to enzyme product D-fructose
1zxx
The crystal structure of phosphofructokinase from lactobacil delbrueckii
Source: Lactobacillus delbrueckii subsp. Bulga organism_taxid: 1585. Strain: subsp. Bulgaricus. Gene: pfka. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (319 residues) CATH domains: 3.40.50.450 3.40.50.460
2hig
Crystal structure of phosphofructokinase apoenzyme from tryp brucei.
Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: pfk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (440 residues) CATH domains: Unassigned 3.40.50.450 3.40.50.460
2pfk
The crystal structure of unliganded phosphofructokinase from escherichia coli
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B, C, D (301 residues) CATH domains: 3.40.50.450 3.40.50.460
3cqd
Structure of the tetrameric inhibited form of phosphofructokinase-2 from escherichia coli
Source: Escherichia coli. Strain: k12. Expressed in: escherichia coli.
Chains: A, B (304 residues) CATH domain: 3.40.1190.20
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3f5m
Crystal structure of atp-bound phosphofructokinase from tryp brucei
Source: Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (458 residues) CATH domains: Unassigned 3.40.50.450 3.40.50.460
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3n1c
Crystal structure of the phosphofructokinase-2 from escheric in complex with fructose-6-phosphate
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b1723, jw5280, pfk2, pfkb. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (309 residues) CATH domain: 3.40.1190.20
Bound ligand:   Het Group F6P corresponds to enzyme reactant D-fructose
3o8l
Structure of phosphofructokinase from rabbit skeletal muscle
Source: Oryctolagus cuniculus. European rabbit,japanese white rabbit,dome rabbit,rabbits. Organism_taxid: 9986. Gene: pfkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (748 residues) CATH domains: 3.40.50.450 3.40.50.460 3.40.50.450 3.40.50.460
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group ADP is 43.33% similar to enzyme reactant D-fructose
3o8n
Structure of phosphofructokinase from rabbit skeletal muscle
Source: Oryctolagus cuniculus. European rabbit,japanese white rabbit,dome rabbit,rabbits. Organism_taxid: 9986. Gene: pfkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (748 residues) CATH domains: 3.40.50.450 3.40.50.460 3.40.50.450 3.40.50.460
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
3o8o
Structure of phosphofructokinase from saccharomyces cerevisi
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: pfk1, ygr240c, g8599. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Gene: pfk2, ymr205c, ym8325.06c.
Chains: A, B, C, D, E, F, G, H (750 residues) CATH domains: 3.40.50.450 3.40.50.460 3.40.50.450 3.40.50.460
Bound ligand:   Het Group F6P corresponds to enzyme reactant D-fructose
3opy
Crystal structure of pichia pastoris phosphofructokinase in state
Source: Pichia pastoris. Yeast. Organism_taxid: 638632. Strain: dsmz 70382. Strain: dsmz 70382
Chains: A, B, C, D, E, F, G, H (936 residues) CATH domains: Unassigned 3.40.50.450 3.40.50.460 3.40.50.450 3.40.50.460
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3pfk
Phosphofructokinase. Structure and control
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Cell_line: 293.
Chain: A (319 residues) CATH domains: 3.40.50.450 3.40.50.460
3u39
Crystal stucture of the apo bacillus stearothermophilus phosphofructokinase
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: pfka, pfk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (319 residues) CATH domains: 3.40.50.450 3.40.50.460
3umo
Crystal structure of the phosphofructokinase-2 from escheric in complex with potassium
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b1723, jw5280, pfk2, pfkb. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (309 residues) CATH domain: 3.40.1190.20
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3ump
Crystal structure of the phosphofructokinase-2 from escheric in complex with cesium and atp
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b1723, jw5280, pfk2, pfkb. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (309 residues) CATH domain: 3.40.1190.20
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3uqd
Crystal structure of the phosphofructokinase-2 from escheric in complex with substrates and products
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b1723, jw5280, pfk2, pfkb. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (309 residues) CATH domain: 3.40.1190.20
3uqe
Crystal structure of the phosphofructokinase-2 mutant y23d f escherichia coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b1723, jw5280, pfk2, pfkb. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (307 residues) CATH domain: 3.40.1190.20
4a3s
Crystal structure of pfk from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Strain: 168. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (319 residues) CATH domains: 3.40.50.450 3.40.50.460
4i36
Crystal structure of the bacillus stearothermophilus phosphofructokinase mutant d12a
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Strain: na. Gene: pfk, pfka. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (318 residues) CATH domains: 3.40.50.450 3.40.50.460
4i4i
Crystal structure of bacillus stearothermophilus phosphofruc mutant t156a bound to pep
Source: Geobacillus stearothermophilus. Bacillus stearothermophilus. Organism_taxid: 1422. Gene: pfk, pfka. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (319 residues) CATH domains: 3.40.50.450 3.40.50.460
Bound ligand:   Het Group PEP is 44.44% similar to enzyme reactant D-fructose
4i7e
Crystal structure of the bacillus stearothermophilus phosphofructokinase mutant d12a in complex with pep
Source: Bacillus stearothermophilus. Organism_taxid: 1422. Gene: pfk, pfka. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (319 residues) CATH domains: 3.40.50.450 3.40.50.460
Bound ligand:   Het Group PEP is 44.44% similar to enzyme reactant D-fructose
4omt
Crystallization and preliminary crystallographic analysis of muscle phosphofructokinase, the main regulator of glycolysi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pfkm, pfkx. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chain: A (748 residues)
4pfk
Phosphofructokinase. Structure and control
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Cell_line: 293.
Chain: A (319 residues) CATH domains: 3.40.50.450 3.40.50.460
Bound ligands:   Het Group F6P corresponds to enzyme reactant D-fructose
  Het Group ADP corresponds to enzyme product ADP
6pfk
Phosphofructokinase, inhibited t-state
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Atcc: nca1503. Gene: pfk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (319 residues) CATH domains: 3.40.50.450 3.40.50.460
Bound ligand:   Het Group PGA is 47.06% similar to enzyme reactant D-fructose