_EC 2.6.1.7 Kynurenine--oxoglutarate transaminase. 41 PDB entries  
EC 2.-.-.- Transferases. [18,241 PDB entries]
EC 2.6.-.- Transferring nitrogenous groups. [568 PDB entries]
EC 2.6.1.- Transaminases (aminotransferases). [547 PDB entries]
EC 2.6.1.7 Kynurenine--oxoglutarate transaminase. [41 PDB entries]    
1aka

Pathway: Tryptophan Catabolism
Reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
 


L-kynurenine
+
2-oxoglutarate
=
4-(2-aminophenyl)-2,4-dioxobutanoate
+
L-glutamate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Kynurenine aminotransferase. Kynurenine--oxoglutarate aminotransferase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 41 PDB entries in enzyme class E.C.2.6.1.7

  PDB code Protein
1aka
Structural basis for the catalytic activity of aspartate aminotransferase k258h lacking its pyridoxal-5'-phosphate-b lysine residue
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chains: A, B (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1akb
Structural basis for the catalytic activity of aspartate aminotransferase k258h lacking its pyridoxal-5'-phosphate-b lysine residue
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: A (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1akc
Structural basis for the catalytic activity of aspartate aminotransferase k258h lacking its pyridoxal-5'-phosphate- binding lysine residue
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: A (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1ama
Domain closure in mitochondrial aspartate aminotransferase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: A (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1ivr
Structure of aspartate aminotransferase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organelle: mitochondria. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: A (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1map
Crystal structures of true enzymatic reaction intermediates: and glutamate ketimines in aspartate aminotransferase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: A (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1maq
Crystal structures of true enzymatic reaction intermediates: and glutamate ketimines in aspartate aminotransferase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: A (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1oxo
Aspartate aminotransferase, h-asp complex, open conformation
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organelle: mitochondria. Expressed in: unidentified. Expression_system_taxid: 32644
Chains: A, B (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1oxp
Aspartate aminotransferase, h-asp complex, closed conformati
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organelle: mitochondria. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: A (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1tar
Crystalline mitochondrial aspartate aminotransferase exists two conformations
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chains: A, B (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1tas
Crystalline mitochondrial aspartate aminotransferase exists in only two conformations
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chains: A, B (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1tat
Crystalline mitochondrial aspartate aminotransferase exists two conformations
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chains: A, B (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
1w7l
Crystal structure of human kynurenine aminotransferase i
Source: Homo sapiens. Human. Organ: liver. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (415 residues) CATH domains: 3.90.1150.10 3.40.640.10
1w7m
Crystal structure of human kynurenine aminotransferase i in complex with l-phe
Source: Homo sapiens. Human. Organ: liver. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (415 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group DPN is 80.00% similar to enzyme reactant L-kynurenine
1w7n
Crystal structure of human kynurenine aminotransferase i in pmp form
Source: Homo sapiens. Human. Organ: liver. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (415 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PMP is 88.00% similar to enzyme cofactor pyridoxal 5'-phosphate
2qlr
Crystal structure of human kynurenine aminotransferase ii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (425 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group GOL is 45.45% similar to enzyme reactant 2-oxoglutarate
2r2n
The crystal structure of human kynurenine aminotransferase i complex with kynurenine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (425 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group KYN corresponds to enzyme reactant L-kynurenine
  Het Group PMP is 88.24% similar to enzyme cofactor pyridoxal
2vgz
Crystal structure of human kynurenine aminotransferase ii
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (414 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
2xh1
Crystal structure of human kat ii-inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (412 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
Bound ligands:   Het Group GOL is 45.45% similar to enzyme reactant 2-oxoglutarate
  Het Group BF5 is 41.38% similar to enzyme product 4-(2-aminophenyl)-2,4-dioxobutanoate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
2zjg
Crystal structural of mouse kynurenine aminotransferase iii
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ccbl2, kat3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group GOL is 45.45% similar to enzyme reactant 2-oxoglutarate
3b46
Crystal structure of bna3p, a putative kynurenine aminotransferase from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: bna3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (424 residues) CATH domains: 3.90.1150.10 3.40.640.10
3dc1
Crystal structure of kynurenine aminotransferase ii complex alpha-ketoglutarate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (415 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group AKG corresponds to enzyme reactant 2-oxoglutarate
3e2f
Crystal structure of mouse kynurenine aminotransferase iii, form
Source: Mus musculus. Organism_taxid: 10090. Gene: ccbl2, kat3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group GOL is 45.45% similar to enzyme reactant 2-oxoglutarate
3e2y
Crystal structure of mouse kynurenine aminotransferase iii i with glutamine
Source: Mus musculus. Organism_taxid: 10090. Gene: ccbl2, kat3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group GLN is 81.82% similar to enzyme product L-glutamate
  Het Group PMP is 88.24% similar to enzyme cofactor pyridoxal
3e2z
Crystal structure of mouse kynurenine aminotransferase iii i with kynurenine
Source: Mus musculus. Organism_taxid: 10090. Gene: ccbl2, kat3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group KYN corresponds to enzyme reactant L-kynurenine
  Het Group PMP is 88.24% similar to enzyme cofactor pyridoxal
3fvs
Human kynurenine aminotransferase i in complex with glycerol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccbl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (419 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group GOL is 45.45% similar to enzyme reactant 2-oxoglutarate
3fvu
Crystal structure of human kynurenine aminotransferase i in with indole-3-acetic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccbl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (419 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group IAC is 64.71% similar to enzyme reactant L-kynurenine
3fvx
Human kynurenine aminotransferase i in complex with tris
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccbl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (419 residues) CATH domains: 3.90.1150.10 3.40.640.10
3hlm
Crystal structure of mouse mitochondrial aspartate aminotransferase/kynurenine aminotransferase iv
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: got-2, got2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
3pd6
Crystal structure of mouse mitochondrial aspartate aminotran newly identified kynurenine aminotransferase-iv
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: got-2, got2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
3pdb
Crystal structure of mouse mitochondrial aspartate aminotran complex with oxaloacetic acid
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: got2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
3ue8
Kynurenine aminotransferase ii inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (410 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
4gdy
Kynurenine aminotransferase ii inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (415 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
4ge4
Kynurenine aminotransferase ii inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (422 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group 0KE is 48.39% similar to enzyme cofactor pyridoxal
4ge7
Kynurenine aminotransferase ii inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (428 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group 0K5 is 41.67% similar to enzyme cofactor pyridoxal
4ge9
Kynurenine aminotransferase ii inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (428 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
4geb
Kynurenine aminotransferase ii inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aadat, kat2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (428 residues) CATH domains: Unassigned 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group 0LD is 44.12% similar to enzyme cofactor pyridoxal
4wp0
Crystal structure of human kynurenine aminotransferase-i wit terminal v5-hexahistidine tag
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccbl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D (416 residues)
7aat
X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chains: A, B (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
8aat
X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chains: A, B (401 residues) CATH domains: 3.90.1150.10 3.40.640.10
9aat
X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Expressed in: unidentified. Expression_system_taxid: 32644
Chains: A, B (401 residues) CATH domains: 3.90.1150.10 3.40.640.10