_EC 2.6.1.62 Adenosylmethionine--8-amino-7-oxononanoate transaminase. 31 PDB entries  
EC 2.-.-.- Transferases. [17,772 PDB entries]
EC 2.6.-.- Transferring nitrogenous groups. [549 PDB entries]
EC 2.6.1.- Transaminases (aminotransferases). [528 PDB entries]
EC 2.6.1.62 Adenosylmethionine--8-amino-7-oxononanoate transaminase. [31 PDB entries]    
1dty

Reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4- methylthio-2-oxobutanoate + 7,8-diaminononanoate.
 


S-adenosyl-L-methionine
+
8-amino-7-oxononanoate
=
S-adenosyl-4- methylthio-2-oxobutanoate
+
7,8-diaminononanoate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 7,8-diamino-pelargonic acid aminotransferase. 7,8-diaminononanoate aminotransferase. Adenosylmethionine--8-amino-7-oxononanoate aminotransferase. Dapa aminotransferase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: S-adenosylhomocysteine can also act as donor.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 31 PDB entries in enzyme class E.C.2.6.1.62

  PDB code Protein
1dty
Crystal structure of adenosylmethionine-8-amino-7-oxonanoate aminotransferase with pyridoxal phosphate cofactor.
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (429 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1mgv
Crystal structure of the r391a mutant of 7,8-diaminopelargon synthase
Source: Escherichia coli. Organism_taxid: 562. Gene: bioa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (428 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1mly
Crystal structure of 7,8-diaminopelargonic acid synthase in with the cis isomer of amiclenomycin
Source: Escherichia coli. Organism_taxid: 562. Gene: bioa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group ACZ is 80.00% similar to enzyme reactant 8-amino-7-oxononanoate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1mlz
Crystal structure of 7,8-diaminopelargonic acid synthase in with the trans-isomer of amiclenomycin.
Source: Escherichia coli. Organism_taxid: 562. Gene: bioa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group TZA is 80.00% similar to enzyme reactant 8-amino-7-oxononanoate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1qj3
Crystal structure of 7,8-diaminopelargonic acid synthase in complex with 7-keto-8-aminopelargonic acid
Source: Escherichia coli. Organism_taxid: 562. Strain: bl21(de3). Cellular_location: cytoplasm. Plasmid: pet24. Gene: bioa. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (416 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group KAP corresponds to enzyme reactant 8-amino-7-oxononanoate
  Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1qj5
Crystal structure of 7,8-diaminopelargonic acid synthase
Source: Escherichia coli. Organism_taxid: 562. Strain: bl21(de3). Cellular_location: cytoplasm. Plasmid: pet24. Gene: bioa. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (428 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
1s06
Crystal structure of the r253k mutant of 7,8- diaminopelargonic acid synthase
Source: Escherichia coli. Organism_taxid: 562. Gene: bioa, b0774. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (428 residues) CATH domains: 3.90.1150.10 3.40.640.10
1s07
Crystal structure of the r253a mutant of 7,8-diaminopelargon synthase
Source: Escherichia coli. Organism_taxid: 562. Gene: bioa, b0774. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (429 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP corresponds to enzyme cofactor pyridoxal
1s08
Crystal structure of the d147n mutant of 7,8- diaminopelargonic acid synthase
Source: Escherichia coli. Organism_taxid: 562. Gene: bioa, b0774. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (411 residues) CATH domains: 3.90.1150.10 3.40.640.10
1s09
Crystal structure of the y144f mutant of 7,8- diaminopelargonic acid synthase
Source: Escherichia coli. Organism_taxid: 562. Gene: bioa, b0774. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
1s0a
Crystal structure of the y17f mutant of 7,8- diaminopelargonic acid synthase
Source: Escherichia coli. Organism_taxid: 562. Gene: bioa, b0774. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (428 residues) CATH domains: 3.90.1150.10 3.40.640.10
3bv0
Crystal structure of plp bound 7,8-diaminopelargonic acid sy mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: bioa, rv1568. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (410 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3lv2
Crystal structure of mycobacterium tuberculosis 7,8-diaminop acid synthase in complex with substrate analog sinefungin
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: bioa, mt1619, mtcy336.35c, rv1568. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (421 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group SFG is 50.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group PLP is 93.00% similar to enzyme cofactor pyridoxal 5'-phosphate
3tft
Crystal structure of 7,8-diaminopelargonic acid synthase (bi mycobacterium tuberculosis, pre-reaction complex with a 3,6 dihydropyrid-2-one heterocycle inhibitor
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: bioa, mt1619, mtcy336.35c, rv1568. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (422 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3tfu
Crystal structure of 7,8-diaminopelargonic acid synthase (bi mycobacterium tuberculosis, post-reaction complex with a 3, dihydropyrid-2-one heterocycle inhibitor
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: bioa, mt1619, mtcy336.35c, rv1568. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (417 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PL8 is 53.57% similar to enzyme cofactor pyridoxal
4a0f
Structure of selenomethionine substituted bifunctional dapa aminotransferase-dethiobiotin synthetase from arabidopsis t in its apo form.
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (746 residues) CATH domains: Unassigned 3.90.1150.10 3.40.640.10
4a0g
Structure of bifunctional dapa aminotransferase-dtb syntheta arabidopsis thaliana in its apo form.
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B, C, D (769 residues) CATH domains: Unassigned 3.90.1150.10 3.40.640.10
4a0h
Structure of bifunctional dapa aminotransferase-dtb syntheta arabidopsis thaliana bound to 7-keto 8-amino pelargonic aci
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (748 residues) CATH domains: Unassigned 3.90.1150.10 3.40.640.10
4a0r
Structure of bifunctional dapa aminotransferase-dtb syntheta arabidopsis thaliana bound to dethiobiotin (dtb).
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (755 residues) CATH domains: Unassigned 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group DTB is 86.67% similar to enzyme product 7,8-diaminononanoate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4a6r
Crystal structure of the omega transaminase from chromobacterium violaceum in the apo form, crystallised from polyacrylic acid
Source: Chromobacterium violaceum. Organism_taxid: 536. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (423 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group TA8 is 50.00% similar to enzyme reactant 8-amino-7-oxononanoate
4a6t
Crystal structure of the omega transaminase from chromobacterium violaceum in complex with plp
Source: Chromobacterium violaceum. Organism_taxid: 536. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (454 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4a6u
Crystal structure of the omega transaminase from chromobacterium violaceum in the apo form, crystallised from peg 3350
Source: Chromobacterium violaceum. Organism_taxid: 536. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (389 residues) CATH domains: 3.90.1150.10 3.40.640.10
4a72
Crystal structure of the omega transaminase from chromobacte violaceum in a mixture of apo and plp-bound states
Source: Chromobacterium violaceum. Organism_taxid: 536. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (429 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4ah3
Crystal structure of the holo omega-transaminase from chromobacterium violaceum
Source: Chromobacterium violaceum. Organism_taxid: 536. Strain: dsm30191. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: bl21
Chains: A, B, C, D (455 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4ba4
Crystal structure of the apo omega-transaminase from chromobacterium violaceum
Source: Chromobacterium violaceum. Organism_taxid: 536. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
4ba5
Crystal structure of omega-transaminase from chromobacterium violaceum
Source: Chromobacterium violaceum. Organism_taxid: 536. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PXG is 57.69% similar to enzyme cofactor pyridoxal
4cxq
Mycobaterium tuberculosis transaminase bioa complexed with substrate kapa
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (427 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group KAP corresponds to enzyme reactant 8-amino-7-oxononanoate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4cxr
Mycobaterium tuberculosis transaminase bioa complexed with 1-(1,3-benzothiazol-2-yl)methanamine
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (425 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group 2BG is 41.18% similar to enzyme product 7,8-diaminononanoate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4mqp
Mycobaterium tuberculosis transaminase bioa complexed with 2 hydrazinylbenzo[d]thiazole
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: bioa, rv1568, mt1619, mtcy336.35c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (428 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group 2B1 is 55.56% similar to enzyme cofactor pyridoxal
4mqq
Mycobaterium tuberculosis transaminase bioa complexed with benzo[d]thiazole-2-carbohydrazide
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: bioa, rv1568, mt1619, mtcy336.35c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (428 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group 2B6 is 51.72% similar to enzyme cofactor pyridoxal
4mqr
Mycobaterium tuberculosis transaminase bioa complexed with e hydroxy-4-(((z)-isonicotinoyldiazenyl)methylene)-6-methyl-1 dihydropyridin-3-yl)methyl phosphate
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: bioa, rv1568, mt1619, mtcy336.35c
Chains: A, B (428 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group 2B9 is 57.69% similar to enzyme cofactor pyridoxal