_EC 2.6.1.51 Serine--pyruvate transaminase. 17 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.6.-.- Transferring nitrogenous groups. [555 PDB entries]
EC 2.6.1.- Transaminases (aminotransferases). [533 PDB entries]
EC 2.6.1.51 Serine--pyruvate transaminase. [17 PDB entries]    
1h0c

Reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
 


L-serine
+
pyruvate
=
3-hydroxypyruvate
+
L-alanine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Serine--pyruvate aminotransferase.
Cofactor(s): Pyridoxal 5'-phosphate.
 

Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: The liver enzyme may be identical with Ec 2.6.1.44.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 17 PDB entries in enzyme class E.C.2.6.1.51

  PDB code Protein
1h0c
The crystal structure of human alanine:glyoxylate aminotransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (386 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group AOA is 71.43% similar to enzyme reactant pyruvate
  Het Group GOL is 85.71% similar to enzyme product hydroxypyruvate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
1j04
Structural mechanism of enzyme mistargeting in hereditary ki disease in vitro
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (387 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group AOA is 71.43% similar to enzyme reactant pyruvate
  Het Group GOL is 85.71% similar to enzyme product hydroxypyruvate
2ch1
Structure of anopheles gambiae 3-hydroxykynurenine transamin
Source: Anopheles gambiae. Organism_taxid: 7165. Strain: gasua. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (388 residues) CATH domains: 3.90.1150.10 3.40.640.10
2ch2
Structure of the anopheles gambiae 3-hydroxykynurenine transaminase in complex with inhibitor
Source: Anopheles gambiae. African malaria mosquito. Organism_taxid: 7165. Strain: gasua. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (387 residues) CATH domains: 3.90.1150.10 3.40.640.10
2huf
Crystal structure of aedes aegypti alanine glyoxylate aminotransferase
Source: Aedes aegypti. Yellow fever mosquito. Organism_taxid: 7159. Strain: liverpool. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (385 residues) CATH domains: 3.90.1150.10 3.40.640.10
2hui
Crystal structure of aedes aegypti alanine glyoxylate aminotransferase in complex with glyoxylic acid
Source: Aedes aegypti. Yellow fever mosquito. Organism_taxid: 7159. Strain: liverpool. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (385 residues) CATH domains: 3.90.1150.10 3.40.640.10
2huu
Crystal structure of aedes aegypti alanine glyoxylate aminotransferase in complex with alanine
Source: Aedes aegypti. Yellow fever mosquito. Organism_taxid: 7159. Strain: liverpool. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (385 residues) CATH domains: 3.90.1150.10 3.40.640.10
2yob
High resolution agxt_m structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (385 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group BTB is 40.00% similar to enzyme reactant L-serine
  Het Group GOL is 85.71% similar to enzyme product hydroxypyruvate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3kgw
Crystal structure of putative aminotransferase (aah25799.1) musculus at 1.65 a resolution
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: aah25799.1, agxt, mcg_16569. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (386 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group EDO is 66.67% similar to enzyme reactant pyruvate
  Het Group PLP corresponds to enzyme cofactor pyridoxal
3kgx
Crystal structure of putative aminotransferase (aah25799.1) musculus at 1.80 a resolution
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: aah25799.1, agxt, mcg_16569. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (383 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group EDO is 66.67% similar to enzyme reactant pyruvate
3r9a
Human alanine-glyoxylate aminotransferase in complex with th domain of human pex5p
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agt1, agxt, spat. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pex5, pxr1.
Chains: A, C (387 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group BTB is 40.00% similar to enzyme reactant L-serine
3zrp
Crystal structure and substrate specificity of a thermophili archaeal serine : pyruvate aminotransferase from sulfolobus solfataricus
Source: Sulfolobus solfataricus. Organism_taxid: 273057. Strain: p2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta2.
Chains: A, B (377 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
3zrq
Crystal structure and substrate specificity of a thermophilic archaeal serine : pyruvate aminotransferase from sulfolobus solfataricus
Source: Sulfolobus solfataricus. Organism_taxid: 273057. Strain: p2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta2.
Chains: A, B (382 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group PMP is 88.24% similar to enzyme cofactor pyridoxal
3zrr
Crystal structure and substrate specificity of a thermophili archaeal serine : pyruvate aminotransferase from sulfolobus solfataricus
Source: Sulfolobus solfataricus. Organism_taxid: 273057. Strain: p2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta2.
Chains: A, B (379 residues) CATH domains: 3.40.640.10 3.90.1150.10
Bound ligand:   Het Group PXG is 57.69% similar to enzyme cofactor pyridoxal
4cbr
X-ray structure of the more stable human agxt triple mutant (agxt_hem)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: plyss
Chain: A (385 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligands:   Het Group GOL is 85.71% similar to enzyme product hydroxypyruvate
  Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4cbs
X-ray structure of quintuple mutant of human alanine glyoxylate aminotransferase, agxt_rheam
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: plyss
Chain: A (385 residues) CATH domains: 3.90.1150.10 3.40.640.10
Bound ligand:   Het Group PLP is 93.75% similar to enzyme cofactor pyridoxal
4i8a
Alanine-glyoxylate aminotransferase variant s187f
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agxt, agt1, spat. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (387 residues) CATH domains: 3.90.1150.10 3.40.640.10