_EC 2.6.1.16 Glutamine--fructose-6-phosphate transaminase (isomerizing). 6 PDB entries  
EC 2.-.-.- Transferases. [7,088 PDB entries]
EC 2.6.-.- Transferring nitrogenous groups. [222 PDB entries]
EC 2.6.1.- Transaminases (aminotransferases). [210 PDB entries]
EC 2.6.1.16 Glutamine--fructose-6-phosphate transaminase (isomerizing). [6 PDB entries]    
1gdo

Pathway: UDP-N-acetylglucosamine Biosynthesis
Reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
 


L-glutamine
+
D-fructose 6-phosphate
=
L-glutamate
+
D-glucosamine 6-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): D-fructose-6-phosphate amidotransferase. GlcN6P synthase. Glucosamine-6-phosphate isomerase (glutamine-forming). Glucosamine-6-phosphate synthase. Hexosephosphate aminotransferase. L-glutamine-D-fructose-6-phosphate amidotransferase.
Comments: Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination). Formerly Ec 5.3.1.19.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.2.6.1.16

  PDB code Protein
1gdo
Glutaminase domain of glucosamine 6-phosphate synthase complexed with glutamate
Source: Escherichia coli. Strain: 3000hfr. Atcc: 25257. Expressed in: escherichia coli. Synthetic: yes
Chains: A, B, C, D (238 residues) CATH domain: 3.60.20.10
Bound ligand:   Het Group GLU corresponds to enzyme product L-glutamate
1gms
Glutaminase domain of glucosamine 6-phosphate synthase complexed with l-glu hydroxamate
Source: Escherichia coli. Strain: 3000hfr. Atcc: 25257. Expressed in: escherichia coli.
Chains: A, C, E, G (238 residues) CATH domain: 3.60.20.10
Bound ligand:   Het Group HGA is 90.00% similar to enzyme reactant L-glutamine
2bpl
E.Coli glucosamine-6p synthase in complex with fructose-6p
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (608 residues) CATH domains: 3.60.20.10 3.40.50.10490 3.40.50.10490
Bound ligand:   Het Group F6R corresponds to enzyme reactant D-fructose
2v4m
The isomerase domain of human glutamine-fructose-6- phosphate transaminase 1 (gfpt1) in complex with fructose 6-phosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (352 residues) CATH domains: 3.40.50.10490 3.40.50.10490
Bound ligand:   Het Group F6R corresponds to enzyme reactant D-fructose 6-phosphate
2vf5
Glucosamine-6-phosphate synthase in complex with glucosamine-6-phosphate
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (366 residues) CATH domains: 3.40.50.10490 3.40.50.10490
Bound ligand:   Het Group GLP corresponds to enzyme product D-glucosamine
3hba
Crystal structure of a putative phosphosugar isomerase (sden from shewanella denitrificans os217 at 2.00 a resolution
Source: Shewanella denitrificans os217. Organism_taxid: 318161. Gene: sden_2705, yp_563707.1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (311 residues) CATH domains: 3.40.50.10490 3.40.50.10490
Bound ligand:   Het Group CIT is 64.29% similar to enzyme product L-glutamate