_EC 2.5.1.81 Geranylfarnesyl diphosphate synthase. 1 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.5.-.- Transferring alkyl or aryl groups, other than methyl groups. [1,301 PDB entries]
EC 2.5.1.- Transferring alkyl or aryl groups, other than methyl groups. [1,301 PDB entries]
EC 2.5.1.81 Geranylfarnesyl diphosphate synthase. [1 PDB entries]    
3ipi

Reaction: Geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)- geranylfarnesyl diphosphate + diphosphate.
 


Geranylgeranyl diphosphate
+
isopentenyl diphosphate
= (2E,6E,10E,14E)- geranylfarnesyl diphosphate
+
diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Fgpp synthase.
Comments: The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate. The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. The enzyme is involved in the biosynthesis of C(25)-C(25) membrane lipids. Formerly Ec 2.5.1.n2.
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There are 1 PDB entries in enzyme class E.C.2.5.1.81

  PDB code Protein
3ipi
Crystal structure of a geranyltranstransferase from the methanosarcina mazei
Source: Methanosarcina mazei. Methanosarcina frisia. Organism_taxid: 2209. Strain: atcc baa-159. Gene: mm_0789. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (268 residues) CATH domain: 1.10.600.10