_EC 2.5.1.63 Adenosyl-fluoride synthase. 15 PDB entries  
EC 2.-.-.- Transferases. [18,268 PDB entries]
EC 2.5.-.- Transferring alkyl or aryl groups, other than methyl groups. [1,329 PDB entries]
EC 2.5.1.- Transferring alkyl or aryl groups, other than methyl groups. [1,329 PDB entries]
EC 2.5.1.63 Adenosyl-fluoride synthase. [15 PDB entries]    
1rqp

Reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine.
 


S-adenosyl-L-methionine
+ fluoride
= 5'-deoxy-5'-fluoroadenosine
+
L-methionine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Fluorinase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 15 PDB entries in enzyme class E.C.2.5.1.63

  PDB code Protein
1rqp
Crystal structure and mechanism of a bacterial fluorinating
Source: Streptomyces cattleya. Organism_taxid: 29303. Strain: nrrl8057
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
1rqr
Crystal structure and mechanism of a bacterial fluorinating product complex
Source: Streptomyces cattleya. Organism_taxid: 29303. Gene: fla. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligands:   Het Group 5FD is 64.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group MET corresponds to enzyme product L-methionine
2c2w
The fluorinase from streptomyces cattleya is also a chlorinase. Structure of 5'-chloro-5'-deoxyadenosine crystallised in the fluorinase.
Source: Streptomyces cattleya. Organism_taxid: 29303. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligand:   Het Group 5CD is 64.00% similar to enzyme reactant S-adenosyl-L-methionine
2c4t
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed with an inhibitor, an analogue of s-adenosyl methionine
Source: Streptomyces cattleya. Organism_taxid: 29303. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: de3.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligand:   Het Group SA8 is 50.00% similar to enzyme reactant S-adenosyl-L-methionine
2c4u
Crystal structure of the apo form of the 5'-fluoro-5'- deoxyadenosine synthase enzyme from streptomyces cattleya
Source: Streptomyces cattleya. Organism_taxid: 29303. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: de3.
Chains: A, B, C, D, E, F (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
2c5b
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed with 2'deoxy-5'deoxy- fluoroadenosine.
Source: Streptomyces cattleya. Organism_taxid: 29303. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: de3.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligands:   Het Group 5F1 is 60.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group MET corresponds to enzyme product L-methionine
2c5h
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed with 2'deoxy-adenosine
Source: Streptomyces cattleya. Organism_taxid: 29303. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: de3.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligands:   Het Group 3D1 is 60.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group MET corresponds to enzyme product L-methionine
2cbx
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed with beta-d- erythrofuranosyl-adenosine
Source: Streptomyces cattleya. Organism_taxid: 29303. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: de3.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligand:   Het Group CC5 is 62.00% similar to enzyme reactant S-adenosyl-L-methionine
2cc2
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed with 5'deoxyadenosine
Source: Streptomyces cattleya. Organism_taxid: 29303. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: de3.
Chains: A, B, C (290 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligand:   Het Group 5AD is 66.00% similar to enzyme reactant S-adenosyl-L-methionine
2v7t
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with s-adenosyl-l-homocysteine and chloride ion
Source: Streptomyces cattleya. Organism_taxid: 29303. Strain: nrrl8057. Atcc: 9747. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c43.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
2v7u
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with s-adenosylmethionine and chloride ion
Source: Streptomyces cattleya. Organism_taxid: 29303. Atcc: 9747. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c43.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
2v7v
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from streptomyces cattleya complexed with 5'-fluorodeoxyadenosine
Source: Streptomyces cattleya. Organism_taxid: 29303. Atcc: 9747. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c43.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
2v7w
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158g mutant complexed with 5'-fluorodeoxyadenosin
Source: Streptomyces cattleya. Organism_taxid: 29303. Atcc: 9747. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c43.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
2v7x
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase s158a mutant from streptomyces cattleya complexed with the products, fda and met
Source: Streptomyces cattleya. Organism_taxid: 29303. Atcc: 9747. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c43.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
4cqj
Fluorinase substrate flexibility enables last step aqueous and ambient 18f fluorination of a rgd peptide for positron emission tomography
Source: Streptomyces cattleya. Organism_taxid: 29303. Strain: nrrl8057. Atcc: 9747. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c43.
Chains: A, B, C (291 residues) CATH domains: 3.40.50.10790 2.40.30.90
Bound ligand:   Het Group EFA is 60.00% similar to enzyme reactant S-adenosyl-L-methionine