_EC 2.5.1.54 3-deoxy-7-phosphoheptulonate synthase. 40 PDB entries  
EC 2.-.-.- Transferases. [18,241 PDB entries]
EC 2.5.-.- Transferring alkyl or aryl groups, other than methyl groups. [1,335 PDB entries]
EC 2.5.1.- Transferring alkyl or aryl groups, other than methyl groups. [1,335 PDB entries]
EC 2.5.1.54 3-deoxy-7-phosphoheptulonate synthase. [40 PDB entries]    
1gg1

Pathway: Shikimate and Chorismate Biosynthesis
Reaction: Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate + phosphate.
 


Phosphoenolpyruvate
+
D-erythrose 4-phosphate
+ H(2)O
=
3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate
+
phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 2-dehydro-3-deoxy-phosphoheptonate aldolase. 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase. 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase. 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase. 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase. 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating). 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating). D-erythrose-4-phosphate-lyase.
Comments: Formerly Ec 4.1.2.15.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 40 PDB entries in enzyme class E.C.2.5.1.54

  PDB code Protein
1gg1
Crystal structure analysis of dahp synthase in complex with mn2+ and 2-phosphoglycolate
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (339 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PGA is 90.00% similar to enzyme reactant Phosphoenolpyruvate
1hfb
Crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with phosphoenolpyruvate
Source: Saccharomyces cerevisiae. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chains: A, B, C, D, E, F, G, H (339 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
1kfl
Crystal structure of phenylalanine-regulated 3-deoxy-d- arabino-heptulosonate-7-phosphate synthase (dahp synthase) from e.Coli complexed with mn2+, pep, and phe
Source: Escherichia coli. Organism_taxid: 562. Gene: arog. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (350 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
  Het Group PHE is 42.00% similar to enzyme product 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate
1n8f
Crystal structure of e24q mutant of phenylalanine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (dahp synthase) from escherichia coli in complex with mn2+ and pep
Source: Escherichia coli. Organism_taxid: 562. Gene: arog. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (343 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
1oab
Crystal structure of the tyrosine regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae in complex with phosphoenolpyruvate and manganese(ii)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (343 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
1of6
Crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with tyrosine and manganese
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B, C, D, E, F, G, H (350 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group DTY is 47.62% similar to enzyme product 3-deoxy-D-
1of8
Double complex of the tyrosine sensitive dahp synthase from s. Cerevisiae with co2+, pep and the e4p analogoue g3p
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (339 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
  Het Group G3P is 83.33% similar to enzyme reactant D-erythrose
1ofa
Crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae in complex with phosphoenolpyruvate and cobalt(ii)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (343 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
1ofb
Crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae in complex with manganese(ii)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (345 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose 4-phosphate
1ofo
Crystal structure of the tyrosine regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae in complex with 2-phosphoglycolate
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (344 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PGA is 90.00% similar to enzyme reactant Phosphoenolpyruvate
1ofp
Crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B, C, D (307 residues) CATH domain: 3.20.20.70
1ofq
Crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae in complex with manganese(ii)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B, C, D (343 residues) CATH domain: 3.20.20.70
1ofr
Crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with phenylalanine and manganese
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Other_details: saccharomyces cerevisiae
Chains: A, B, C, D, E, F, G, H (350 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PHE is 42.00% similar to enzyme product 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate
1og0
Crystal structure of the mutant g226s of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with phenylalanine and manganese
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326
Chains: A, B, C, D, E, F, G, H (345 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PHE is 42.00% similar to enzyme product 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate
1qr7
Crystal structure of phenylalanine-regulated 3-deoxy-d- arabino-heptulosonate-7-phosphate synthase from escherichia coli complexed with pb2+ and pep
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (338 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
1rzm
Crystal structure of 3-deoxy-d-arabino-heptulosonate-7-phosp synthase (dahps) from thermotoga maritima complexed with cd and e4p
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: arof, tm0343. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (338 residues) CATH domains: 3.30.70.1140 3.20.20.70
Bound ligands:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
  Het Group E4P corresponds to enzyme reactant D-erythrose
1vr6
Crystal structure of phospho-2-dehydro-3-deoxyheptonate aldo synthase) (tm0343) from thermotoga maritima at 1.92 a resol
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0343. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (343 residues) CATH domains: 3.30.70.1140 3.20.20.70
1vs1
Crystal structure of 3-deoxy-d-arabino-heptulosonate-7- phosphate synthase (dahp synthase) from aeropyrum pernix in complex with mn2+ and pep
Source: Aeropyrum pernix. Organism_taxid: 56636. Gene: ape0581. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (270 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
1zco
Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
2b7o
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: rv2178c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (451 residues) CATH domain: Unassigned
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
2w19
Non-covalent complex between dahp synthase and chorismate mutase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (419 residues) CATH domain: Unassigned
Bound ligand:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose
2w1a
Non-covalent complex between dahp synthase and chorismate mutase from mycobacterium tuberculosis with bound tsa
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (451 residues) CATH domain: Unassigned
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose
  Het Group TSA is 47.83% similar to enzyme product 3-deoxy-D-
2ypo
3-deoxy-d-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (458 residues) CATH domain: Unassigned
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose
  Het Group PHE is 42.86% similar to enzyme product 3-deoxy-D-
2ypp
3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in comp 3 tyrosine molecules
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (460 residues) CATH domain: Unassigned
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose
  Het Group TYR is 47.62% similar to enzyme product 3-deoxy-D-
2ypq
3-deoxy-d-arabino-heptulosonate 7-phosphate synthase with tryptophan and tyrosine bound
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (460 residues) CATH domain: Unassigned
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose
  Het Group TYR is 47.62% similar to enzyme product 3-deoxy-D-
  Het Group PO4 corresponds to enzyme product phosphate
3kgf
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate from mycobacterium tuberculosis complexed with phenylalanin tryptophan
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2178c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (452 residues) CATH domain: Unassigned
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose
  Het Group PHE is 42.86% similar to enzyme product 3-deoxy-D-
  Het Group PO4 corresponds to enzyme product phosphate
3nud
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate from mycobacterium tuberculosis complexed with phenylalanin
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2178c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (440 residues) CATH domain: Unassigned
Bound ligands:   Het Group PHE is 42.00% similar to enzyme product 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate
  Het Group PO4 corresponds to enzyme product phosphate
3nue
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate from mycobacterium tuberculosis complexed with tryptophan
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2178c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (453 residues) CATH domain: Unassigned
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose 4-phosphate
  Het Group PO4 corresponds to enzyme product phosphate
3nv8
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate in complex with phosphoenol pyruvate and manganese (thesit-
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2178c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (462 residues) CATH domain: Unassigned
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
3pfp
Structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate syn mycobacterium tuberculosis in complex with an active site i
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: arog, rv2178c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domain: Unassigned
Bound ligand:   Het Group 035 is 68.18% similar to enzyme product 3-deoxy-D-
3pg8
Truncated form of 3-deoxy-d-arabino-heptulosonate 7-phosphat from thermotoga maritima
Source: Thermotoga maritima. Organism_taxid: 2336. Strain: msb8 (dsm3109). Gene: arof. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose
3pg9
Thermotoga maritima dah7p synthase in complex with inhibitor
Source: Thermotoga maritima. Organism_taxid: 2336. Strain: msb8 (dsm3109). Gene: arof. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (338 residues) CATH domains: 3.30.70.1140 3.20.20.70
3rzi
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate from mycobacterium tuberculosis cocrystallized and complexe phenylalanine and tryptophan
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: arog, rv2178c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (453 residues) CATH domain: Unassigned
Bound ligands:   Het Group GOL is 50.00% similar to enzyme reactant D-erythrose
  Het Group PHE is 42.86% similar to enzyme product 3-deoxy-D-
  Het Group PO4 corresponds to enzyme product phosphate
3tqk
Structure of phospho-2-dehydro-3-deoxyheptonate aldolase fro francisella tularensis schu s4
Source: Francisella tularensis. Organism_taxid: 119856. Strain: tularensis. Gene: arog, ftt_0963c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (341 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group ACT is 40.00% similar to enzyme reactant Phosphoenolpyruvate
4c1k
Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase
Source: Pyrococcus furiosus. Organism_taxid: 2261
Chains: A, B, C, D, E, F (262 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
4c1l
Crystal structure of pyrococcus furiosus 3-deoxy-d-arabino- heptulosonate 7-phosphate synthase i181d interface mutant
Source: Pyrococcus furiosus. Organism_taxid: 2261
Chains: A, B (262 residues) CATH domain: 3.20.20.70
4grs
Crystal structure of a chimeric dah7ps
Source: Thermotoga maritima, pyrococcus furios organism_taxid: 243274, 186497. Strain: msb8, dsm 3638. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (333 residues) CATH domains: 3.30.70.1140 3.20.20.70
Bound ligand:   Het Group TYR is 47.62% similar to enzyme product 3-deoxy-D-
4hsn
Crystal structure of dah7ps from neisseria meningitidis
Source: Neisseria meningitidis. Organism_taxid: 122586. Strain: mc58 (serogroup b). Gene: arog, nmb0307. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (341 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
4hso
Crystal structure of s213g variant dah7ps from neisseria men
Source: Neisseria meningitidis. Organism_taxid: 122586. Strain: mc58 (serogroup b). Gene: arog, nmb0307. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (345 residues) CATH domain: 3.20.20.70
Bound ligands:   Het Group PEP corresponds to enzyme reactant Phosphoenolpyruvate
  Het Group TYR is 47.62% similar to enzyme product 3-deoxy-D-
4ixx
Crystal structure of s213g variant dah7ps without tyr bound neisseria meningitidis
Source: Neisseria meningitidis. Organism_taxid: 122586. Strain: mc58 (serogroup b). Gene: arog, nmb0307. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (340 residues) CATH domain: 3.20.20.70