_EC 2.5.1.15 Dihydropteroate synthase. 53 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.5.-.- Transferring alkyl or aryl groups, other than methyl groups. [1,301 PDB entries]
EC 2.5.1.- Transferring alkyl or aryl groups, other than methyl groups. [1,301 PDB entries]
EC 2.5.1.15 Dihydropteroate synthase. [53 PDB entries]    
1ad1

Pathway: Folate Biosynthesis (late stages)
Reaction: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.
 

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
+
4-aminobenzoate
=
diphosphate
+
dihydropteroate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Dhps. Dihydropteroate diphosphorylase. Dihydropteroate pyrophosphorylase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 53 PDB entries in enzyme class E.C.2.5.1.15

  PDB code Protein
1ad1
Dihydropteroate synthetase (apo form) from staphylococcus aureus
Source: Staphylococcus aureus. Organism_taxid: 1280
Chains: A, B (264 residues) CATH domain: 3.20.20.20
1ad4
Dihydropteroate synthetase complexed with oh-ch2-pterin- pyrophosphate from staphylococcus aureus
Source: Staphylococcus aureus. Organism_taxid: 1280
Chains: A, B (251 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group HH2 is 40.00% similar to enzyme product diphosphate
1aj0
Crystal structure of a ternary complex of e. Coli dihydropte synthase
Source: Escherichia coli. Organism_taxid: 562
Chain: A (282 residues) CATH domain: 3.20.20.20
Bound ligands:   Het Group SAN is 50.00% similar to enzyme reactant 4-aminobenzoate
  Het Group PH2 is 54.17% similar to enzyme product dihydropteroate
1aj2
Crystal structure of a binary complex of e. Coli dihydropter synthase
Source: Escherichia coli. Organism_taxid: 562
Chain: A (282 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 2PH is 40.91% similar to enzyme product diphosphate
1ajz
Structure of dihydropteroate pyrophosphorylase
Source: Escherichia coli. Organism_taxid: 562
Chain: A (282 residues) CATH domain: 3.20.20.20
1eye
1.7 angstrom resolution crystal structure of 6-hydroxymethyl dihydropteroate synthase (dhps) from mycobacterium tubercul complex with 6-hydroxymethylpterin monophosphate
Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (256 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group PMM is 46.43% similar to enzyme product dihydropteroate
1q26
Dihydropteroate synthase from bacillus anthracis
Source: Bacillus anthracis. Bacteria. Strain: a2012. Gene: folp. Expressed in: escherichia coli.
Chain: A (273 residues) CATH domain: 3.20.20.20
1q28
Dihydropteroate syntahse from bacillus anthracis with bound pterine molecule
Source: Bacillus anthracis. Bacteria. Strain: a2012. Gene: folp. Expressed in: escherichia coli.
Chain: A (273 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group PE0 is 54.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
1tws
Dihydropteroate synthetase from bacillus anthracis
Source: Bacillus anthracis. Organism_taxid: 191218. Strain: str. A2012. Gene: folp. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (273 residues) CATH domain: 3.20.20.20
1tww
Dihydropteroate synthetase, with bound substrate analogue pt bacillus anthracis
Source: Bacillus anthracis. Organism_taxid: 191218. Strain: str. A2012. Gene: folp. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (266 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group HH2 is 40.91% similar to enzyme product diphosphate
1twz
Dihydropteroate synthetase, with bound substrate analogue pt bacillus anthracis
Source: Bacillus anthracis. Organism_taxid: 191218. Strain: str. A2012. Gene: folp. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (266 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group PMM is 46.43% similar to enzyme product dihydropteroate
1tx0
Dihydropteroate synthetase, with bound product analogue pter from bacillus anthracis
Source: Bacillus anthracis. Organism_taxid: 191218. Strain: str. A2012. Gene: folp. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (265 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group PT1 corresponds to enzyme product dihydropteroate
1tx2
Dihydropteroate synthetase, with bound inhibitor manic, from anthracis
Source: Bacillus anthracis. Organism_taxid: 191218. Strain: str. A2012. Gene: folp. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (269 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 680 is 44.00% similar to enzyme product dihydropteroate
2bmb
X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (513 residues) CATH domains: 3.30.70.560 3.20.20.20
Bound ligand:   Het Group PMM is 46.00% similar to enzyme product dihydropteroate
2vef
Dihydropteroate synthase from streptococcus pneumoniae
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (279 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
2veg
Dihydropteroate synthase from streptococcus pneumoniae: complex with 6-hydroxymethyl-7,8-dihydropterin monophosphate
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (279 residues) CATH domain: 3.20.20.20
Bound ligands:   Het Group PO4 is 55.00% similar to enzyme product diphosphate
  Het Group PMM is 46.00% similar to enzyme product dihydropteroate
2y5j
Crystal structure of burkholderia cenocepacia dihydropteroate synthase.
Source: Burkholderia cenocepacia. Organism_taxid: 95486. Strain: lmg 16656. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: belgian co-ordinated collections of micro- organisms, bacteria collection (bccm/lmg)
Chain: A (269 residues) CATH domain: 3.20.20.20
2y5s
Crystal structure of burkholderia cenocepacia dihydropteroat synthase complexed with 7,8-dihydropteroate.
Source: Burkholderia cenocepacia. Organism_taxid: 95486. Strain: lmg 16656. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: belgian co-ordinated collections of micro- organisms, bacteria collection (bccm/lmg)
Chains: A, B (280 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 78H corresponds to enzyme product dihydropteroate
3h21
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (263 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B52 is 45.00% similar to enzyme reactant 4-aminobenzoate
3h22
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (261 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B53 is 41.67% similar to enzyme product dihydropteroate
3h23
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: bao_0074, folp. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (274 residues) CATH domain: 3.20.20.20
3h24
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (267 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B55 is 45.83% similar to enzyme product dihydropteroate
3h26
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (263 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B56 is 50.00% similar to enzyme product dihydropteroate
3h2a
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (261 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B57 is 40.00% similar to enzyme product dihydropteroate
3h2c
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.20.20.20
3h2e
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (273 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B59 is 48.15% similar to enzyme product dihydropteroate
3h2f
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (269 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B60 is 56.52% similar to enzyme product dihydropteroate
3h2m
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (270 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B61 is 51.85% similar to enzyme product dihydropteroate
3h2n
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B62 is 56.52% similar to enzyme product dihydropteroate
3h2o
Structural studies of pterin-based inhibitors of dihydropter synthase
Source: Bacillus anthracis str. A2012. Organism_taxid: 191218. Gene: folp, bao_0074. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group B63 is 56.67% similar to enzyme product dihydropteroate
3tr9
Structure of a dihydropteroate synthase (folp) in complex wi acid from coxiella burnetii
Source: Coxiella burnetii. Organism_taxid: 777. Strain: rsa493. Gene: cbu_1351, folp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (277 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group PT1 corresponds to enzyme product dihydropteroate
3tya
Dihydropteroate synthase in complex with product
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 191218. Strain: a2012. Gene: folp, bas0071, ba_0071, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 78H corresponds to enzyme product dihydropteroate
3tyb
Dihydropteroate synthase in complex with phba and dhp+
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 191218. Strain: a2012. Gene: folp, bas0071, ba_0071, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domain: 3.20.20.20
Bound ligands:   Het Group PHB is 81.82% similar to enzyme reactant 4-aminobenzoate
  Het Group XHP is 56.52% similar to enzyme product dihydropteroate
3tyc
Dihydropteroate synthase in complex with dhp+
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 191218. Strain: a2012. Gene: folp, bas0071, ba_0071, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (266 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group XHP is 56.52% similar to enzyme product dihydropteroate
3tyd
Dihydropteroate synthase in complex with ppi and dhp+
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 191218. Strain: a2012. Gene: folp, bas0071, ba_0071, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (271 residues) CATH domain: 3.20.20.20
Bound ligands:   Het Group POP corresponds to enzyme product diphosphate
  Het Group XHP is 56.52% similar to enzyme product dihydropteroate
3tye
Dihydropteroate synthase in complex with dhp-stz
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 191218. Strain: a2012. Gene: folp, bas0071, ba_0071, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (267 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group XTZ is 62.50% similar to enzyme product dihydropteroate
3tyu
Crystal structure of dihydropteroate synthetase with product
Source: Yersinia pestis. Organism_taxid: 632. Strain: kim d27. Gene: dhps, folp, y0683, ypo3501, yp_0582. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (265 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group PT1 corresponds to enzyme product dihydropteroate
3tyz
Crystal structure of the yersinia pestis dihydropteroate syn with substrate transition state complex.
Source: Yersinia pestis. Organism_taxid: 632. Strain: kim d27. Gene: dhps, folp, y0683, ypo3501, yp_0582. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (275 residues) CATH domain: 3.20.20.20
Bound ligands:   Het Group PAB corresponds to enzyme reactant 4-aminobenzoate
  Het Group POP corresponds to enzyme product diphosphate
  Het Group XHP is 56.52% similar to enzyme product dihydropteroate
3tzf
Crystal structure of the yersinia pestis dihydropteroate syn sulfonamide drug complex.
Source: Yersinia pestis. Organism_taxid: 632. Strain: kim d27. Gene: dhps, folp, y0683, ypo3501, yp_0582. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (275 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group HH2 is 40.91% similar to enzyme product diphosphate
3tzn
Crystal structure of the yersinia pestis dihydropteroate syn
Source: Yersinia pestis. Organism_taxid: 632. Strain: kim d27. Gene: dhps, folp, y0683, ypo3501, yp_0582. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (243 residues) CATH domain: 3.20.20.20
3v5o
Structural and mechanistic studies of catalysis and sulfa dr resistance in dihydropteroate synthase
Source: Bacillus anthracis. Organism_taxid: 592021. Strain: a0248. Gene: folp, baa_0084. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.20.20.20
4d8a
Crystal structure of b. Anthracis dhps with compound 21
Source: Bacillus anthracis. Anthrax. Organism_taxid: 191218. Strain: a2012. Gene: folp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (263 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 0HY is 42.86% similar to enzyme reactant 4-aminobenzoate
4d8z
Crystal structure of b. Anthracis dhps with compound 24
Source: Bacillus anthracis. Anthrax. Organism_taxid: 191218. Strain: a2012. Gene: folp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (263 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 0J2 is 45.00% similar to enzyme reactant 4-aminobenzoate
4d9p
Crystal structure of b. Anthracis dhps with compound 17
Source: Bacillus anthracis. Anthrax. Organism_taxid: 191218. Strain: a2012. Gene: folp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (264 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group Z17 is 42.86% similar to enzyme reactant 4-aminobenzoate
4daf
Crystal structure of b. Anthracis dhps with compound 19
Source: Bacillus anthracis. Anthrax. Organism_taxid: 191218. Strain: a2012. Gene: folp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (252 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 0J4 is 47.37% similar to enzyme reactant 4-aminobenzoate
4dai
Crystal structure of b. Anthracis dhps with compound 23
Source: Bacillus anthracis. Anthrax. Organism_taxid: 191218. Strain: a2012. Gene: folp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (262 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 0J5 is 42.11% similar to enzyme reactant 4-aminobenzoate
4db7
Crystal structure of b. Anthracis dhps with compound 25
Source: Bacillus anthracis. Anthrax. Organism_taxid: 191218. Strain: a2012. Gene: folp. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (259 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group Z25 is 47.37% similar to enzyme reactant 4-aminobenzoate
4hb7
The structure of dihydropteroate synthase from staphylococcu subsp. Aureus mu50.
Source: Staphylococcus aureus. Organism_taxid: 158878. Strain: subsp. Aureus mu50. Gene: folp, sav0514. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (253 residues) CATH domain: 3.20.20.20
4nhv
Crystal structure of b. Anthracis dhps with interfacial comp (trifluoromethyl)-1,2-benzoxazol-3-amine
Source: Bacillus anthracis. Anthrax, anthrax bacterium. Organism_taxid: 1392. Strain: a2012. Gene: bas0071, ba_0071, folp, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (274 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 2O6 is 50.00% similar to enzyme reactant 4-aminobenzoate
4nil
Crystal structure of b. Anthracis dhps with compound 5: 4- [(trifluoromethyl)sulfanyl]benzamide
Source: Bacillus anthracis. Anthrax, anthrax bacterium. Organism_taxid: 1392. Strain: a2012. Gene: folp, bas0071, ba_0071, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (274 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 2O8 is 50.00% similar to enzyme reactant 4-aminobenzoate
4nir
Crystal structure of b. Anthracis dhps with compound 6: 3-[6 (trifluoromethyl)-1h-benzimidazol-2-yl]propan-1-ol
Source: Bacillus anthracis. Anthrax, anthrax bacterium. Organism_taxid: 1392. Strain: a2012. Gene: folp, bas0071, ba_0071, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (274 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group 6DH is 42.11% similar to enzyme reactant 4-aminobenzoate
4nl1
Crystal structure of b. Anthracis dhps with compound 11: (e) (trifluoromethyl)benzyl]-1-[4-(trifluoromethyl)phenyl]metha
Source: Bacillus anthracis. Anthrax, anthrax bacterium. Organism_taxid: 1392. Strain: a2012. Gene: folp, bas0071, ba_0071, gbaa_0071. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (273 residues) CATH domain: 3.20.20.20
Bound ligand:   Het Group Z13 is 43.75% similar to enzyme reactant 4-aminobenzoate
4pzv
Crystal structure of francisella tularensis hppk-dhps in com bisubstrate analog hppk inhibitor j1d
Source: Francisella tularensis subsp. Tularens organism_taxid: 177416. Strain: schu s4 / schu 4. Gene: foik, folk, ftt_0942c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (413 residues) CATH domain: 3.30.70.560