_EC 2.4.99.1 Beta-galactoside alpha-2,6-sialyltransferase. 2 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.4.-.- Glycosyltransferases. [1,920 PDB entries]
EC 2.4.99.- Transferring other glycosyl groups. [77 PDB entries]
EC 2.4.99.1 Beta-galactoside alpha-2,6-sialyltransferase. [2 PDB entries]    
4js1

Reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosamine = Cmp + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N- acetyl-beta-D-glucosamine.
 


CMP-N-acetylneuraminate
+
beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosamine
=
CMP
+ alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N- acetyl-beta-D-glucosamine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Beta-galactosamide alpha-2,6-sialyltransferase. CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase.
Comments: The terminal beta-D-galactosyl residue of the oligosaccharide of glycoproteins, as well as lactose, can act as acceptor.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.2.4.99.1

  PDB code Protein
4js1
Crystal structure of human beta-galactoside alpha-2,6- sialyltransferase 1 in complex with cytidine and phosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: st6gal1, siat1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293
Chain: A (318 residues) CATH domain: Unassigned
Bound ligands:   Het Group NAG is 53.85% similar to enzyme reactant N-acetyllactosamine
  Het Group CTN is 80.95% similar to enzyme product CMP
4js2
Crystal structure of human beta-galactoside alpha-2,6- sialyltransferase 1 in complex with cmp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: st6gal1, siat1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293
Chain: A (318 residues) CATH domain: Unassigned
Bound ligands:   Het Group NAG is 53.85% similar to enzyme reactant N-acetyllactosamine
  Het Group C corresponds to enzyme product CMP