_EC 2.4.2.8 Hypoxanthine phosphoribosyltransferase. 35 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.4.-.- Glycosyltransferases. [1,920 PDB entries]
EC 2.4.2.- Pentosyltransferases. [899 PDB entries]
EC 2.4.2.8 Hypoxanthine phosphoribosyltransferase. [35 PDB entries]    
1bzy

Reaction: Imp + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
 


IMP
+
diphosphate
=
hypoxanthine
+
5-phospho-alpha-D-ribose 1-diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Guanine phosphoribosyltransferase. HGPRTase. Hypoxanthine-guanine phosphoribosyltransferase. Imp diphosphorylase. Imp pyrophosphorylase. Transphosphoribosidase.
Comments: Guanine and 6-mercaptopurine can replace hypoxanthine.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 35 PDB entries in enzyme class E.C.2.4.2.8

  PDB code Protein
1bzy
Human hgprtase with transition state inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (214 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group IMU is 42.00% similar to enzyme reactant Inosine 5'-phosphate
  Het Group POP corresponds to enzyme reactant diphosphate
1d6n
Ternary complex structure of human hgprtase, prpp, mg2+, and the inhibitor hpp reveals the involvement of the flexible loop in substrate binding
Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (214 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group PPO is 66.00% similar to enzyme product Hypoxanthine
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
1g9s
Crystal structure of a complex between e.Coli hprt and imp
Source: Escherichia coli. Organism_taxid: 562. Gene: hpt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (169 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine
1g9t
Crystal structure of e.Coli hprt-gmp complex
Source: Escherichia coli. Organism_taxid: 562. Gene: hpt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (167 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group 5GP is 95.00% similar to enzyme reactant Inosine 5'-phosphate
  Het Group N is 59.00% similar to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
1grv
Hypoxanthine phosphoribosyltransferase from e. Coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (168 residues) CATH domain: 3.40.50.2020
1hmp
The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound gmp
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (214 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group 5GP is 95.83% similar to enzyme reactant Inosine
1i0i
Analysis of an invariant aspartic acid in hprts-glutamine mutant
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (187 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group 7HP is 66.00% similar to enzyme product Hypoxanthine
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
1i0l
Analysis of an invariant aspartic acid in hprts-asparagine mutant
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (192 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group 7HP is 66.00% similar to enzyme product Hypoxanthine
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
1i13
Analysis of an invariant aspartic acid in hprts-alanine mutant
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (187 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group 7HP is 66.00% similar to enzyme product Hypoxanthine
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
1i14
Analysis of an invariant aspartic acid in hprts-glutamic acid mutant
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (187 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group 7HP is 66.00% similar to enzyme product Hypoxanthine
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
1j7j
Crystal structure of the hprt from salmonella typhimurium
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: hpt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (163 residues) CATH domain: 3.40.50.2020
1p17
Hypoxanthine phosphoribosyltransferase from trypanosoma cruzi, k68r mutant, complexed with the product imp
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: hgprt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (194 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine 5'-phosphate
1p18
Hypoxanthine phosphoribosyltransferase from trypanosoma cruzi, k68r mutant, ternary substrates complex
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: hgprt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (187 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group 7HP is 66.00% similar to enzyme product Hypoxanthine
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
1p19
Hypoxanthine phosphoribosyltransferase from trypanosoma cruzi, in complex with the product imp
Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: hgprt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (187 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine 5'-phosphate
1tc1
A 1.4 angstrom crystal structure for the hypoxanthine phosphoribosyltransferase of trypanosoma cruzi
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (175 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group FMB is 66.00% similar to enzyme product Hypoxanthine
1tc2
Ternary substrate complex of the hypoxanthine phosphoribosyltransferase from trypanosoma cruzi
Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (186 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group 7HP is 66.00% similar to enzyme product Hypoxanthine
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
1z7g
Free human hgprt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hprt1, hprt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (199 residues) CATH domain: 3.40.50.2020
2jky
Saccharomyces cerevisiae hypoxanthine-guanine phosphoribosyltransferase in complex with gmp (guanosine 5' -monophosphate) (tetragonal crystal form)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: y1846. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (207 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group 5GP is 95.83% similar to enzyme reactant Inosine
2jkz
Saccharomyces cerevisiae hypoxanthine-guanine phosphoribosyltransferase in complex with gmp (guanosine 5' -monophosphate) (orthorhombic crystal form)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: y1846. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (201 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group 5GP is 95.83% similar to enzyme reactant Inosine
2xbu
Saccharomyces cerevisiae hypoxanthine-guanine phosphoribosyltransferase in complex with gmp (monoclinic crystal form)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: y1846. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (201 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group 5GP is 95.83% similar to enzyme reactant Inosine
2yws
Crystal structure of hypoxanthine-guanine phosphoribosyltransferase from thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (166 residues) CATH domain: 3.40.50.2020
2ywt
Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with gmp from thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (166 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group 5GP is 95.00% similar to enzyme reactant Inosine 5'-phosphate
2ywu
Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with imp from thermus thermophilus hb8
Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (164 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group IMP corresponds to enzyme reactant Inosine 5'-phosphate
3gep
Human hypoxanthine guanine phosphoribosyltranserfase in complex with (s)-9-(3-hydroxy-2-phosphonylmethoxypropyl) guanine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hprt, hprt1, hpt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (212 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group 24H is 51.00% similar to enzyme reactant Inosine 5'-phosphate
3ggc
Human hypoxanthine-guanine phosphoribosyltransferase in comp 9-(2-phosphonoethoxyethyl)hypoxanthine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hprt, hprt1, hpt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (212 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group H26 is 52.63% similar to enzyme product Hypoxanthine
3ggj
Human hypoxanthine-guanine phosphoribosyltransferase in comp 9-(2-phosphonoethoxyethyl)guanine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hprt, hprt1, hpt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (214 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group 25H is 50.00% similar to enzyme product Hypoxanthine
3h83
2.06 angstrom resolution structure of a hypoxanthine-guanine phosphoribosyltransferase (hpt-1) from bacillus anthracis s ancestor'
Source: Bacillus anthracis str. 'Ames ancestor anthrax,anthrax bacterium. Organism_taxid: 261594. Strain: ames ancestor. Gene: bas0063, ba_0063, hpt-1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (198 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
3hvu
1.95 angstrom crystal structure of complex of hypoxanthine-g phosphoribosyltransferase from bacillus anthracis with 2-(n morpholino)ethanesulfonic acid (mes)
Source: Bacillus anthracis str. 'Ames ancestor anthrax,anthrax bacterium. Organism_taxid: 261594. Strain: ames ancestor. Gene: bas0063, ba_0063, hpt-1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (185 residues) CATH domain: 3.40.50.2020
3kb8
2.09 angstrom resolution structure of a hypoxanthine-guanine phosphoribosyltransferase (hpt-1) from bacillus anthracis s ancestor' in complex with gmp
Source: Bacillus anthracis str.. Organism_taxid: 261594. Strain: 'ames ancestor'. Gene: baa_0076, hpt, hpt-1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (201 residues) CATH domain: 3.40.50.2020
Bound ligands:   Het Group 5GP is 95.83% similar to enzyme reactant Inosine
  Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
3o7m
1.98 angstrom resolution crystal structure of a hypoxanthine phosphoribosyltransferase (hpt-2) from bacillus anthracis s ancestor'
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 261594. Strain: ames ancestor. Gene: bas4712, ba_5074, gbaa5074, gbaa_5074, hpt-2, hpt2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (166 residues) CATH domain: 3.40.50.2020
4ijq
Human hypoxanthine-guanine phosphoribosyltransferase in comp [(2-((guanine-9h-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(me diphosphonic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hprt1, hprt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (198 residues) CATH domain: 3.40.50.2020
4kn6
Crystal structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with 6-fluoro-3-hydrox pyrazinecarboxamide (t-705) ribose-5'-monophosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hprt1, hprt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (192 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group 1RP is 80.77% similar to enzyme reactant Inosine
4lyy
Crystal structure of hypoxanthine phosphoribosyltransferase shewanella pealeana atcc 700345, nysgrc target 029677.
Source: Shewanella pealeana. Organism_taxid: 398579. Strain: atcc 700345. Gene: 5661087, spea_0688. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (171 residues) CATH domain: 3.40.50.2020
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4pfq
Crystal structure of hypoxanthine phosphoribosyltransferase brachybacterium faecium dsm 4810, nysgrc target 029763.
Source: Brachybacterium faecium. Organism_taxid: 446465. Strain: dsm 4810. Gene: bfae_12790. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (177 residues) CATH domain: 3.40.50.2020
4qyi
1.95 angstrom resolution crystal structure of a hypoxanthine phosphoribosyltransferase (hpt-2) from bacillus anthracis s ancestor' with hepes molecule in the active site
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 1392. Strain: ames ancestor. Gene: bas4712, ba_5074, gbaa_5074, hpt-2, hpt2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E (170 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate