_EC 2.4.2.4 Thymidine phosphorylase. 11 PDB entries  
EC 2.-.-.- Transferases. [17,772 PDB entries]
EC 2.4.-.- Glycosyltransferases. [1,895 PDB entries]
EC 2.4.2.- Pentosyltransferases. [887 PDB entries]
EC 2.4.2.4 Thymidine phosphorylase. [11 PDB entries]    
1azy

Reaction: Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
 


Thymidine
+
phosphate
=
thymine
+
2-deoxy-alpha-D-ribose 1-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Pyrimidine phosphorylase.
Comments: In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by Ec 2.4.2.6. Formerly Ec 2.4.2.23.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 11 PDB entries in enzyme class E.C.2.4.2.4

  PDB code Protein
1azy
Structural and theoretical studies suggest domain movement p active conformation of thymidine phosphorylase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12
Chains: A, B (440 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
1otp
Structural and theoretical studies suggest domain movement p active conformation of thymidine phosphorylase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12
Chain: A (440 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
1tpt
Three-dimensional structure of thymidine phosphorylase from escherichia coli at 2.8 angstroms resolution
Source: Escherichia coli. Organism_taxid: 562.
Chain: A (440 residues)
Bound ligand:   Het Group TDR corresponds to enzyme product Thymine
1uou
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (438 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
Bound ligand:   Het Group CMU is 50.00% similar to enzyme reactant Thymidine
2j0f
Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (446 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
Bound ligand:   Het Group TDR corresponds to enzyme product Thymine
2tpt
Structural and theoretical studies suggest domain movement p active conformation of thymidine phosphorylase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12
Chain: A (440 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
2wk5
Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (449 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
Bound ligand:   Het Group GOL is 46.00% similar to enzyme product 2-deoxy-alpha-D-ribose 1-phosphate
2wk6
Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (447 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
Bound ligand:   Het Group IUR is 80.00% similar to enzyme product Thymine
4ead
Thymidine phosphorylase from e.Coli with 3'-azido-2'-fluoro- dideoxyuridine
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b4382, deoa, jw4345, tpp, ttg. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (440 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
4eaf
Thymidine phosphorylase from e.Coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: deoa, tpp, ttg, b4382, jw4345. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (440 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
4lhm
Thymidine phosphorylase from e.Coli with 3'-azido-3'-deoxyth
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: deoa, tpp, ttg, b4382, jw4345. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (440 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
Bound ligands:   Het Group AZZ is 80.00% similar to enzyme reactant Thymidine
  Het Group GOL is 46.15% similar to enzyme product 2-deoxy-alpha-D-ribose