_EC 2.4.2.30 NAD(+) ADP-ribosyltransferase. 201 PDB entries  
EC 2.-.-.- Transferases. [19,007 PDB entries]
EC 2.4.-.- Glycosyltransferases. [2,007 PDB entries]
EC 2.4.2.- Pentosyltransferases. [947 PDB entries]
EC 2.4.2.30 NAD(+) ADP-ribosyltransferase. [201 PDB entries]    
1a26

Pathway: NAD+ ADP-ribosyltransferase
Reaction: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
 


NAD(+)
+ (ADP-D-ribosyl)(n)-acceptor
=
nicotinamide
+ (ADP-D- ribosyl)(n+1)-acceptor
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): ADP-ribosyltransferase (polymerizing). Poly(adenosine diphosphate ribose) polymerase. Poly(ADP-ribose) synthetase. Poly(ADP-ribose)polymerase.
Comments: The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 201 PDB entries in enzyme class E.C.2.4.2.30

  PDB code Protein
1a26
The catalytic fragment of poly(adp-ribose) polymerase complexed with carba-NAD
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Cell_line: sf9. Organelle: nucleus. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (351 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group CNA is 61.00% similar to enzyme reactant NAD(+)
1efy
Crystal structure of the catalytic fragment of poly (adp- ribose) polymerase complexed with a benzimidazole inhibitor
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group BZC is 45.00% similar to enzyme product nicotinamide
1gs0
Crystal structure of the catalytic fragment of murine poly (adp-ribose) polymerase-2
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (345 residues) CATH domains: 1.20.142.10 3.90.228.10
1pax
The catalytic fragment of poly(adp-ribose) polymerase complexed with 3,4-dihydro-5-methyl-isoquinolinone
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Cell_line: sf9. Organelle: nucleus. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group DHQ is 61.00% similar to enzyme product nicotinamide
1uk0
Crystal structure of catalytic domain of human poly(adp- ribose) polymerase with a novel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (350 residues) CATH domains: 1.20.142.10 3.90.228.10
1uk1
Crystal structure of human poly(adp-ribose) polymerase complexed with a potent inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (350 residues) CATH domains: 1.20.142.10 3.90.228.10
1v9x
Solution structure of the first zn-finger domain of poly(adp-ribose) polymerase-1
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: riken cdna rafl09-59-l22. Other_details: cell-free protein synthesis
Chain: A (114 residues) CATH domain: 3.30.1740.10
1wok
Crystal structure of catalytic domain of human poly(adp- ribose) polymerase complexed with a quinoxaline-type inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group CNQ is 45.00% similar to enzyme product nicotinamide
1x4r
Solution structure of wwe domain in parp14 protein
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: parp14. Other_details: cell free protein synthesis
Chain: A (99 residues) CATH domain: Unassigned
2cok
Solution structure of brct domain of poly(adp-ribose) polymerase-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Other_details: cell-free protein synthesis
Chain: A (113 residues) CATH domain: 3.40.50.10190
2cr9
Solution structure of wgr domain of poly(adp-ribose) polymerase-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Other_details: cell-free protein synthesis
Chain: A (139 residues) CATH domain: Unassigned
2cs2
Solution structure of the second zn-finger domain of poly(adp-ribose) polymerase-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Other_details: cell-free protein synthesis
Chain: A (134 residues) CATH domain: 3.30.1740.10
2dhx
Solution structure of the rrm domain in the human poly (adp- ribose) polymerase family, member 10 variant
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp10. Other_details: cell-free protein synthesis
Chain: A (104 residues) CATH domain: 3.30.70.330
2dk6
Solution structure of wwe domain in poly (adp-ribose) polymerase family, member 11 (parp 11)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp11. Other_details: cell free protein synthesis
Chain: A (102 residues)
2dmj
Solution structure of the first zf-parp domain of human poly(adp-ribose)polymerase-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: parp1, adprt, ppol. Other_details: cell-free protein synthesis
Chain: A (106 residues) CATH domain: 3.30.1740.10
2eoc
Solution structure of the wgr domain from human poly [adp- ribose] polymerase-3
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: cell-free protein synthesis
Chain: A (124 residues)
2jvn
Domain c of human parp-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (126 residues) CATH domain: Unassigned
2l30
Human parp-1 zinc finger 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (108 residues) CATH domain: 3.30.1740.10
2l31
Human parp-1 zinc finger 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (112 residues) CATH domain: 3.30.1740.10
2le0
Parp brct domain
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: parp1, adprt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (106 residues) CATH domain: 3.40.50.10190
2pa9
Human poly(adp-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp3, adprt3, adprtl3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (357 residues) CATH domains: 1.20.142.10 3.90.228.10
2paw
The catalytic fragment of poly(adp-ribose) polymerase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Cell_line: sf9. Organelle: nucleus. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (348 residues) CATH domains: 1.20.142.10 3.90.228.10
2pax
The catalytic fragment of poly(adp-ribose) polymerase complexed with 4-amino-1,8-naphthalimide
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Cell_line: sf9. Organelle: nucleus. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group 4AN is 56.00% similar to enzyme product nicotinamide
2pqf
Human poly(adp-ribose) polymerase 12, catalytic fragment in with an inhibitor 3-aminobenzoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp12, zc3hdc1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (185 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group GAB is 58.33% similar to enzyme product nicotinamide
2rcw
Parp complexed with a620223
Source: Homo sapiens. Human. Gene: parp1, adprt, ppol. Expressed in: escherichia coli
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group AAI is 42.00% similar to enzyme product nicotinamide
2rd6
Parp complexed with a861695
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group 78P is 50.00% similar to enzyme product nicotinamide
2rf5
Crystal structure of human tankyrase 1- catalytic parp domai
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (207 residues) CATH domain: 3.90.228.10
2riq
Crystal structure of the third zinc-binding domain of human
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (135 residues) CATH domains: Unassigned Unassigned
2y0i
Factor inhibiting hif-1 alpha in complex with tankyrase-2 (t fragment peptide (21-mer)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
Chain: S (14 residues)
3blj
Crystal structure of human poly(adp-ribose) polymerase 15, c fragment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp15, bal3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (192 residues) CATH domain: 3.90.228.10
3c49
Human poly(adp-ribose) polymerase 3, catalytic fragment in complex with an inhibitor ku0058948
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp3, adprt3, adprtl3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (357 residues) CATH domains: 1.20.142.10 3.90.228.10
3c4h
Human poly(adp-ribose) polymerase 3, catalytic fragment in c with an inhibitor dr2313
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp3, adprt3, adprtl3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (357 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group DRL is 75.00% similar to enzyme product nicotinamide
3ce0
Human poly(adp-ribose) polymerase 3, catalytic fragment in complex with an inhibitor pj34
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp3, adprt3, adprtl3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (352 residues) CATH domains: 1.20.142.10 3.90.228.10
3fhb
Human poly(adp-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid
Source: Homo sapiens. Organism_taxid: 9606. Gene: parp3, adprt3, adprtl3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (357 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group GAB is 58.00% similar to enzyme product nicotinamide
3gey
Crystal structure of human poly(adp-ribose) polymerase 15, c fragment in complex with an inhibitor pj34
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal3, parp15. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (188 residues) CATH domain: 3.90.228.10
3gjw
Parp complexed with a968427
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
3gn7
Parp complexed with a861696
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group 3GN is 50.00% similar to enzyme product nicotinamide
3goy
Crystal structure of human poly(adp-ribose) polymerase 14, c fragment in complex with an inhibitor 3-aminobenzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (181 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group 3AB is 72.73% similar to enzyme product nicotinamide
3hkv
Human poly(adp-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp10. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (192 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group 3AB is 72.00% similar to enzyme product nicotinamide
3kcz
Human poly(adp-ribose) polymerase 2, catalytic fragment in c with an inhibitor 3-aminobenzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt2, adprtl2, parp2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (353 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group 3AB is 72.73% similar to enzyme product nicotinamide
3kh6
Human poly(adp-ribose) polymerase 15, macro domain 2 in comp adenosine-5-diphosphoribose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal3, parp15. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (176 residues) CATH domain: 3.40.220.10
Bound ligand:   Het Group APR is 77.78% similar to enzyme reactant NAD(+)
3kjd
Human poly(adp-ribose) polymerase 2, catalytic fragment in c with an inhibitor abt-888
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt2, adprtl2, parp2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group 78P is 50.00% similar to enzyme product nicotinamide
3kr7
Human tankyrase 2 - catalytic parp domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (209 residues) CATH domain: 3.90.228.10
3kr8
Human tankyrase 2 - catalytic parp domain in complex with an xav939
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (206 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group XAV is 42.86% similar to enzyme product nicotinamide
3l3l
Parp complexed with a906894
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group L3L is 47.00% similar to enzyme product nicotinamide
3l3m
Parp complexed with a927929
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (348 residues) CATH domains: 1.20.142.10 3.90.228.10
3mhj
Human tankyrase 2 - catalytic parp domain in complex with 1- (trifluoromethyl)-5h-benzo[c][1,8]naphtyridine-6-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (208 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group M3F is 45.00% similar to enzyme product nicotinamide
3mhk
Human tankyrase 2 - catalytic parp domain in complex with 2- pyridyl)-7,8-dihydro-5h-thiino[4,3-d]pyrimidin-4-ol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (210 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group P4L is 52.94% similar to enzyme product nicotinamide
3od8
Human parp-1 zinc finger 1 (zn1) bound to DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt, parp1, ppol. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized DNA. Other_details: chemically synthesized DNA
Chains: A, B, C, D, E, F, G, H (87 residues) CATH domain: 3.30.1740.10
3oda
Human parp-1 zinc finger 1 (zn1) bound to DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt, parp1, ppol. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized DNA
Chains: A, B, C, D, E, F, G, H (87 residues) CATH domain: 3.30.1740.10
3odc
Human parp-1 zinc finger 2 (zn2) bound to DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt, parp1, ppol. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized DNA. Other_details: chemically synthesized DNA
Chains: A, B (93 residues) CATH domain: 3.30.1740.10
3ode
Human parp-1 zinc finger 2 (zn2) bound to DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt, parp1, ppol. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized DNA. Other_details: chemically synthesized DNA
Chains: A, B (91 residues) CATH domain: 3.30.1740.10
3p0n
Human tankyrase 2 - catalytic parp domain in complex with an
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (207 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group BPU is 50.00% similar to enzyme product nicotinamide
3p0p
Human tankyrase 2 - catalytic parp domain in complex with an
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (206 residues) CATH domain: 3.90.228.10
3p0q
Human tankyrase 2 - catalytic parp domain in complex with an
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (208 residues) CATH domain: 3.90.228.10
3pax
The catalytic fragment of poly(adp-ribose) polymerase complexed with 3-methoxybenzamide
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Cell_line: sf9. Organelle: nucleus. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group 3MB is 66.00% similar to enzyme product nicotinamide
3q6z
Human parp14 (artd8)-macro domain 1 in complex with adenosin diphosphoribose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (185 residues) CATH domain: 3.40.220.10
Bound ligand:   Het Group APR is 77.78% similar to enzyme reactant NAD(+)
3q71
Human parp14 (artd8) - macro domain 2 in complex with adenos diphosphoribose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (203 residues) CATH domain: 3.40.220.10
Bound ligand:   Het Group AR6 is 77.78% similar to enzyme reactant NAD(+)
3se2
Human poly(adp-ribose) polymerase 14 (parp14/artd8) - cataly in complex with 6(5h)-phenanthridinone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (186 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group LDR is 50.00% similar to enzyme product nicotinamide
3smi
Human poly(adp-ribose) polymerase 14 (parp14/artd8) - cataly in complex with a quinazoline inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (177 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group QDR is 45.00% similar to enzyme product nicotinamide
3smj
Human poly(adp-ribose) polymerase 14 (parp14/artd8) - cataly in complex with a pyrimidine-like inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (188 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group FDR is 64.29% similar to enzyme product nicotinamide
3twq
Crystal structure of arc4 from human tankyrase 2 (apo form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (164 residues) CATH domain: 1.25.40.20
3twr
Crystal structure of arc4 from human tankyrase 2 in complex peptide from human 3bp2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: solid-state synthesized peptide
Chains: A, B, C, D (157 residues) CATH domain: 1.25.40.20
3tws
Crystal structure of arc4 from human tankyrase 2 in complex peptide from human terf1 (chimeric peptide)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: solid-state synthesized peptide
Chains: A, B, C, D (157 residues) CATH domain: 1.25.40.20
3twt
Crystal structure of arc4 from human tankyrase 2 in complex peptide from human mcl1 (chimeric peptide)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: solid-state synthesized peptide
Chains: A, B, C, D (156 residues) CATH domain: 1.25.40.20
3twu
Crystal structure of arc4 from human tankyrase 2 in complex peptide from human mcl1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: solid-state synthesized peptide
Chain: A (160 residues) CATH domain: 1.25.40.20
3twv
Crystal structure of arc4 from human tankyrase 2 in complex peptide from human numa1 (chimeric peptide)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: solid-state synthesized peptide
Chains: A, B, C, D (155 residues) CATH domain: 1.25.40.20
3tww
Crystal structure of arc4 from human tankyrase 2 in complex peptide from human lnpep (chimeric peptide)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: solid-state synthesized peptide
Chains: A, B (157 residues) CATH domain: 1.25.40.20
3twx
Crystal structure of arc4 from human tankyrase 2 in complex peptide from human fnbp1 (chimeric peptide)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: solid-state synthesized peptide
Chains: A, B (158 residues) CATH domain: 1.25.40.20
3u9h
Complex structure of human tankyrase 2 with nicotinamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (208 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group NCA corresponds to enzyme product nicotinamide
3u9y
Crystal structure of human tankyrase 2 catalytic domain in c with olaparib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (208 residues) CATH domain: 3.90.228.10
3ua9
Crystal structure of human tankyrase 2 in complex with a sel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (207 residues) CATH domain: 3.90.228.10
3udd
Tankyrase-1 in complex with small molecule inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (204 residues) CATH domain: 3.90.228.10
3uh2
Tankyrase-1 in complexed with pj34
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (199 residues) CATH domain: 3.90.228.10
3uh4
Tankyrase-1 complexed with nvp-xav939
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (209 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group XAV is 42.86% similar to enzyme product nicotinamide
3utm
Crystal structure of a mouse tankyrase-axin complex
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tankryase1, tnks, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: axin, axin1, fu.
Chains: A, B (320 residues) CATH domains: 1.25.40.20 1.25.40.20
3v2b
Human poly(adp-ribose) polymerase 15 (artd7, bal3), macro do complex with adenosine-5-diphosphoribose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal3, parp15. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (176 residues) CATH domain: 3.40.220.10
Bound ligand:   Het Group AR6 is 77.78% similar to enzyme reactant NAD(+)
3vfq
Human parp14 (artd8, bal2) - macro domains 1 and 2 in comple adenosine-5-diphosphoribose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (375 residues) CATH domains: 3.40.220.10 3.40.220.10
Bound ligand:   Het Group AR6 is 77.78% similar to enzyme reactant NAD(+)
3w51
Tankyrase in complex with 2-hydroxy-4-methylquinoline
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (209 residues) CATH domain: Unassigned
Bound ligand:   Het Group AJ2 is 50.00% similar to enzyme product nicotinamide
4abk
Human parp14 (artd8, bal2) - macro domain 3 in complex with adenosine-5-diphosphoribose
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3 prare.
Chain: A (182 residues) CATH domain: 3.40.220.10
Bound ligand:   Het Group AR6 is 77.78% similar to enzyme reactant NAD(+)
4abl
Human parp14 (artd8, bal2) - macro domain 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3 prare.
Chain: A (181 residues) CATH domain: 3.40.220.10
4av1
Crystal structure of the human parp-1 DNA binding domain in complex with DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: human cdna library. Synthetic: yes. Synthetic construct.
Chains: A, B, C, D (86 residues) CATH domain: 3.30.1740.10
4avu
Crystal structure of human tankyrase 2 in complex with 6(5h) -phenanthridinone
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group LDR is 50.00% similar to enzyme product nicotinamide
4avw
Crystal structure of human tankyrase 2 in complex with tiq-a
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group G18 is 53.33% similar to enzyme product nicotinamide
4bfp
Crystal structure of human tankyrase 2 in complex with wiki4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
4bj9
Crystal structure of human tankyrase 2 in complex with eb-47
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (207 residues) CATH domain: Unassigned
4bjb
Crystal structure of human tankyrase 2 in complex with pj-34
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chain: A (200 residues) CATH domain: Unassigned
4bjc
Crystal structure of human tankyrase 2 in complex with rucap
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chain: A (197 residues) CATH domain: Unassigned
4bs4
Crystal structure of human tankyrase 2 in complex with 4'-isopropylflavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (207 residues) CATH domain: Unassigned
4bu3
Crystal structure of human tankyrase 2 in complex with 2-phenyl-3,4-dihydroquinazolin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group F40 is 52.94% similar to enzyme product nicotinamide
4bu5
Crystal structure of human tankyrase 2 in complex with 2-(4- hydroxyphenyl)-3,4-dihydroquinazolin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group 3F4 is 50.00% similar to enzyme product nicotinamide
4bu6
Crystal structure of human tankyrase 2 in complex with 2-(4- aminophenyl)-3,4-dihydroquinazolin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group RGK is 50.00% similar to enzyme product nicotinamide
4bu7
Crystal structure of human tankyrase 2 in complex with 2-(4- bromophenyl)-3,4-dihydroquinazolin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, C (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group 25F is 50.00% similar to enzyme product nicotinamide
4bu8
Crystal structure of human tankyrase 2 in complex with 4-(4- oxo-1,4-dihydroquinazolin-2-yl)benzonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, C (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group 27F is 47.37% similar to enzyme product nicotinamide
4bu9
Crystal structure of human tankyrase 2 in complex with 2-(4- methoxyphenyl)-3,4-dihydroquinazolin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group 08C is 47.37% similar to enzyme product nicotinamide
4bua
Crystal structure of human tankyrase 2 in complex with 2-(4- (methylsulfanyl)phenyl)-3,4-dihydroquinazolin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, C (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group 91F is 47.37% similar to enzyme product nicotinamide
4bud
Crystal structure of human tankyrase 2 in complex with 2-(4- tert-butylphenyl)-1,4-dihydroquinazolin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, C (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group 29F is 42.86% similar to enzyme product nicotinamide
4bue
Crystal structure of human tankyrase 2 in complex with 3-met n-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)butanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
4buf
Crystal structure of human tankyrase 2 in complex with 2-(4- acetylphenyl)-3,4-dihydroquinazolin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group F36 is 45.00% similar to enzyme product nicotinamide
4bui
Crystal structure of human tankyrase 2 in complex with methyl 4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, C (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group W2E is 42.86% similar to enzyme product nicotinamide
4bus
Crystal structure of human tankyrase 2 in complex with 2-(4- (4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group 32F is 40.91% similar to enzyme product nicotinamide
4but
Crystal structure of human tankyrase 2 in complex with 4-(4- oxo-3,4-dihydroquinazolin-2-yl)benzene-1-sulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
Bound ligand:   Het Group 31F is 42.86% similar to enzyme product nicotinamide
4buu
Crystal structure of human tankyrase 2 in complex with (4- (4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)methanesulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (209 residues) CATH domain: Unassigned
Bound ligand:   Het Group F38 is 40.91% similar to enzyme product nicotinamide
4buv
Crystal structure of human tankyrase 2 in complex with n-(4- (4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)thiophene-2-carbox
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, C (208 residues) CATH domain: Unassigned
4buw
Crystal structure of human tankyrase 2 in complex with 2-(4- (2-oxo-1,3-oxazolidin-3-yl)phenyl)-3,4- dihydroquinazolin-4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
4bux
Crystal structure of human tankyrase 2 in complex with 3-(( 4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)methyl) imidazolidine-2,4-dione
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, C (208 residues) CATH domain: Unassigned
4buy
Crystal structure of human tankyrase 2 in complex with 5- methyl-5-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl) imidazolidine-2,4-dione
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2.
Chains: A, B (208 residues) CATH domain: Unassigned
4d86
Human parp14 (artd8, bal2) - macro domains 1 and 2 in comple adenosine-5-diphosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (374 residues) CATH domains: 3.40.220.10 3.40.220.10
Bound ligand:   Het Group ADP is 61.36% similar to enzyme reactant NAD(+)
4dqy
Structure of human parp-1 bound to a DNA double strand break
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: parp1, adprt, ppol. Synthetic: yes
Chains: A, B, C, D, E, F (86 residues) CATH domain: 3.30.1740.10
4dvi
Crystal structure of tankyrase 1 with iwr2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (206 residues) CATH domain: 3.90.228.10
4f0d
Human artd15/parp16 in complex with 3-aminobenzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: c15orf30, parp16. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (238 residues) CATH domain: Unassigned
Bound ligand:   Het Group 3AB is 72.73% similar to enzyme product nicotinamide
4f0e
Human adp-ribosyltransferase 7 (artd7/parp15), catalytic dom complex with sto1102
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal3, parp15. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (198 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group 0RU is 45.00% similar to enzyme product nicotinamide
4f1l
Human artd8 (parp14, bal2) - catalytic domain in complex wit inhibitor a16(z)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (187 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group 0RY is 44.44% similar to enzyme product nicotinamide
4f1q
Human artd8 (parp14, bal2) - catalytic domain in complex wit
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bal2, kiaa1268, parp14. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (183 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group 0RZ is 44.44% similar to enzyme product nicotinamide
4gv0
Human artd3 (parp3) - catalytic domain in complex with inhib me0355
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (354 residues) CATH domains: 1.20.142.10 3.90.228.10
4gv2
Human artd3 (parp3) - catalytic domain in complex with inhib me0354
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (354 residues) CATH domains: Unassigned 3.90.228.10
4gv4
Human artd3 (parp3) - catalytic domain in complex with inhib me0328
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (357 residues) CATH domains: Unassigned 3.90.228.10
4gv7
Human artd1 (parp1) - catalytic domain in complex with inhib me0328
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (348 residues) CATH domains: Unassigned 3.90.228.10
Bound ligand:   Het Group MEW is 75.00% similar to enzyme product nicotinamide
4hhy
Crystal structure of parp catalytic domain in complex with n inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt, parp1, ppol. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (349 residues) CATH domains: Unassigned 3.90.228.10
4hhz
Crystal structure of parp catalytic domain in complex with n inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt, parp1, ppol. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (349 residues) CATH domains: Unassigned 3.90.228.10
4hki
Tankyrase 2 in complex with flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, H, D (161 residues) CATH domain: Unassigned
4hkk
Complex structure of human tankyrase 2 with apigenin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (162 residues) CATH domain: Unassigned
4hkn
Complex structure of human tankyrase 2 with luteolin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C (162 residues) CATH domain: Unassigned
4hl5
Complex structure of human tankyrase 2 with 7-hydroxy -4'- methoxyflavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C (161 residues) CATH domain: Unassigned
4hlf
Crystal structure of tankyrase 2 in complex with 7,3',4'- trihydroxyflavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4hlg
Crystal structure of tankyrase 2 in complex with 3'-hydroxyf
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4hlh
Crystal structure of tankyrase 2 in complex with 4'-fluorofl
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4hlk
Crystal structure of tankyrase 2 in complex with 4'-methylfl
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4hlm
Crystal structure of tankyrase 2 in complex with 3',4'- dihydroxyflavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4hmh
Crystal structure of tankyrase 2 in complex with 7,3-dihydro
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C (161 residues) CATH domain: Unassigned
4hyf
Structural basis and sar for od 270, a lead stage 1,2,4-tria specific tankyrase1/2 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (227 residues) CATH domain: 3.90.228.10
Bound ligand:   Het Group NCA corresponds to enzyme product nicotinamide
4i9i
Crystal structure of tankyrase 1 with compound 4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (212 residues) CATH domain: Unassigned
4iue
Tankyrase in complex with 7-(2-fluorophenyl)-4-methyl-1,2- dihydroquinolin-2-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (209 residues) CATH domain: Unassigned
4j1z
Tankyrase 2 in complex with 4-chloro-1,2-dihydrophatalzin-on
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (209 residues) CATH domain: Unassigned
Bound ligand:   Het Group 495 is 61.54% similar to enzyme product nicotinamide
4j21
Tankyrase 2 in complex with 7-(4-amino-2-chlorophenyl)-4- methylquinolin-2(1h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (209 residues) CATH domain: Unassigned
4j22
Tankyrase 2 in complex with 3-chloro-4-(4-methyl-2-oxo-1,2- dihydroquinolin-7-yl)-n-[2-(morpholin-4-yl)ethyl]benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (209 residues) CATH domain: Unassigned
4j3l
Tankyrase 2 in complex with 3-chloro-n-(2-methoxyethyl)-4-(4 oxo-1,2-dihydroquinolin-7-yl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (209 residues) CATH domain: Unassigned
4j3m
Tankyrase 2 in complex with 3-chloro-4-(4-methyl-2-oxo-1,2- dihydroquinolin-7-yl)benzoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (208 residues) CATH domain: Unassigned
4k4e
Co-crystal structure of tnks1 with compound 52 [n~2-(5-chlor methoxyphenyl)-n-[trans-4-(2-oxo-2,3-dihydro-1h-benzimidazo cyclohexyl]glycinamide]
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (208 residues) CATH domain: Unassigned
4k4f
Co-crystal structure of tnks1 with compound 18 [4-[(4s)-5,5- 2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-n-(quinolin-8-yl)benzam
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (210 residues) CATH domain: Unassigned
4krs
Tankyrase-1 complexed with small molecule inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (204 residues) CATH domain: Unassigned
4kzl
Crystal structure of human tankyrase 2 in complex with 4'-fl flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4kzq
Crystal structure of human tankyrase 2 in complex with 4' -h flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4kzu
Crystal structure of human tankyrase 2 in complex with 4' -b flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l09
Crystal structure of human tankyrase 2 in complex with 4-(4- chromen-2-yl)benzoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l0b
Tankyrase 2 in complex with 4'-dimethylamino flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l0i
Tankyrase 2 catalytic domain in complex with ethyl 4-(4-oxo- chromen-2-yl)benzoate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l0s
Tankyrase 2 in complex with 4'-cyano flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l0t
Tankyrase 2 in complex with 4'-nitro flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l0v
Tankyrase 2 in complex with 4'-chloro flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l10
Tankyrase 2 in complex with 4'-methoxy flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l2f
Tankyrase 2 in complex with 6-chloro flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l2g
Tankyrase 2 in complex with 6- fluoro flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l2k
Tankyrase 2 in complex with 2-(1,3-benzodioxol-5-yl)-4h-chro
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l31
Tankyrase 2 in complex with methyl 4-(4-oxochromen-2-yl)benz
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l32
Tankyrase 2 in complex with 2-[4-(4-methylpiperazine-1-carbo phenyl]chromen-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l33
Tankyrase 2 in complex with cyanomethyl 4-(4-oxo-4h-chromen- benzoate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l34
Tankyrase 2 in complex with 4'-tetrazole flavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C, B, D (161 residues) CATH domain: Unassigned
4l6s
Parp complexed with benzo[1,4]oxazin-3-one inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21de3. Gene: adprt, parp 1, parp1, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (351 residues) CATH domains: Unassigned 3.90.228.10
4l6z
Human artd3 (parp3) - catalytic domain in complex with inhib sto1168
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt3, adprtl3, parp3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (354 residues) CATH domains: Unassigned 3.90.228.10
4l70
Human artd3 (parp3) - catalytic domain in complex with inhib me0352
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt3, adprtl3, parp3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (354 residues) CATH domains: Unassigned 3.90.228.10
4l7l
Human artd3 (parp3) - catalytic domain in complex with inhib me0368
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt3, adprtl3, parp3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (353 residues) CATH domains: Unassigned 3.90.228.10
4l7n
Human artd3 (parp3) - catalytic domain in complex with inhib sto1542
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt3, adprtl3, parp3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (353 residues) CATH domains: Unassigned 3.90.228.10
4l7o
Human artd3 (parp3) - catalytic domain in complex with inhib sto1542
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt3, adprtl3, parp3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (354 residues) CATH domains: Unassigned 3.90.228.10
4l7p
Human artd3 (parp3) - catalytic domain in complex with inhib me0395
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt3, adprtl3, parp3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (350 residues) CATH domains: Unassigned 3.90.228.10
4l7r
Human artd3 (parp3) - catalytic domain in complex with inhib me0400
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt3, adprtl3, parp3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (353 residues) CATH domains: Unassigned 3.90.228.10
Bound ligand:   Het Group M00 is 42.86% similar to enzyme product nicotinamide
4l7u
Human artd3 (parp3) - catalytic domain in complex with inhib me0398
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: adprt3, adprtl3, parp3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (352 residues) CATH domains: Unassigned 3.90.228.10
4li6
Tankyrase-1 complexed with small molecule inhibitor n-[(4-ox dihydroquinazolin-2-yl)methyl]-3-phenyl-n-(thiophen-2-ylmet propanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (204 residues) CATH domain: Unassigned
4li7
Tankyrase-1 complexed with small molecule inhibitor 4-chloro n-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-2-methoxyben
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (201 residues) CATH domain: Unassigned
4li8
Tankyrase-1 complexed with small molecule inhibitor 2-[4-(4- fluorobenzoyl)piperidin-1-yl]-n-[(4-oxo-3,5,7,8-tetrahydro- pyrano[4,3-d]pyrimidin-2-yl)methyl]-n-(thiophen-2-ylmethyl)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (199 residues) CATH domain: Unassigned
4m7b
Human tankyrase 2 - catalytic parp domain in complex with an upf1854
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C (206 residues) CATH domain: Unassigned
4msg
Crystal structure of tankyrase 1 with compound 22
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (211 residues) CATH domain: Unassigned
4msk
Co-crystal structure of tankyrase 1 with compound 34
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (211 residues) CATH domain: Unassigned
4mt9
Co-crystal structure of tankyrase 1 with compound 49
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (210 residues) CATH domain: Unassigned
4n3r
Co-crystal structure of tankyrase 1 with compound 2 (5-(2- aminoquinazolin-6-yl)-n-(4,4-dimethyl-2-oxo-1,2,3,4- tetrahydroquinolin-7-yl)-2-fluorobenzamide)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (212 residues) CATH domain: Unassigned
4n4t
Co-crystal structure of tankyrase 1 with compound 3 [(4s)-3- amino-5-(pyrimidin-2-yl)pyridin-3-yl]phenyl}-5,5-dimethyl-4 3-oxazolidin-2-one]
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tnks, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (212 residues) CATH domain: Unassigned
4n4v
Co-crystal structure of tankyrase 1 with compound 4 [(4s)-3- [6-amino-5-(pyrimidin-2-yl)pyridin-3-yl]cyclohexyl}-5,5-dim phenyl-1,3-oxazolidin-2-one]
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (211 residues) CATH domain: Unassigned
4oa7
Crystal structure of tankyrase1 in complex with iwr1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks, parp5a, parpl, tin1, tinf1, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (205 residues)
4opx
Structure of human parp-1 bound to a DNA double strand break complex with (2r)-5-fluoro-2-methyl-2,3-dihydro-1-benzofura carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C, D, F (222 residues)
Bound ligand:   Het Group 2UR is 53.33% similar to enzyme product nicotinamide
4oqa
Structure of human parp-1 bound to a DNA double strand break complex with (2z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-di benzofuran-7-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C, D, F (222 residues)
4oqb
Structure of human parp-1 bound to a DNA double strand break complex with (2z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzyliden 2,3-dihydro-1-benzofuran-7-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C, D, F (222 residues)
4pax
The catalytic fragment of poly(adp-ribose) polymerase complexed with 8-hydroxy-2-methyl-3-hydro-quinazolin-4-one
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Cell_line: sf9. Organelle: nucleus. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (350 residues) CATH domains: 1.20.142.10 3.90.228.10
Bound ligand:   Het Group NU1 is 69.00% similar to enzyme product nicotinamide
4pjt
Structure of parp1 catalytic domain bound to inhibitor bmn 6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp1, adprt, ppol. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (338 residues) CATH domains: Unassigned 3.90.228.10
4pjv
Structure of parp2 catalytic domain bound to inhibitor bmn 6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parp2, adprt2, adprtl2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (339 residues) CATH domains: 1.20.142.10 3.90.228.10
4pml
Crystal structure of human tankyrase 2 in complex with 3-ami benzamide.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: enterobacteria phage l1. Expression_system_taxid: 268588
Chains: A, B, C, D (198 residues) CATH domain: Unassigned
Bound ligand:   Het Group 3AB is 72.73% similar to enzyme product nicotinamide
4pnl
Crystal structure of tnks-2 in complex with dr2313.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: enterobacteria phage l1. Expression_system_taxid: 268588
Chains: A, B, C, D (198 residues) CATH domain: Unassigned
Bound ligand:   Het Group DRL is 75.00% similar to enzyme product nicotinamide
4pnm
Crystal structure of human tankyrase 2 in complex with nu102
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (199 residues) CATH domain: Unassigned
Bound ligand:   Het Group NU1 is 69.23% similar to enzyme product nicotinamide
4pnn
Crystal structure of human tankyrase 2 in complex with 4hqn.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (199 residues) CATH domain: Unassigned
Bound ligand:   Het Group JPZ is 81.82% similar to enzyme product nicotinamide
4pnq
Crystal structure of human tankyrase 2 in complex with 5aiq.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (202 residues) CATH domain: Unassigned
Bound ligand:   Het Group 32X is 61.54% similar to enzyme product nicotinamide
4pnr
Crystal structure of human tankyrase 2 in complex with tiq-a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (200 residues) CATH domain: Unassigned
Bound ligand:   Het Group G18 is 53.33% similar to enzyme product nicotinamide
4pns
Crystal structure of human tankyrase 2 in complex with inh2b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (197 residues) CATH domain: Unassigned
Bound ligand:   Het Group 32Y is 46.67% similar to enzyme product nicotinamide
4pnt
Crystal structure of human tankyrase 2 in complex with 1,5-i
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (199 residues) CATH domain: Unassigned
Bound ligand:   Het Group IQD is 61.54% similar to enzyme product nicotinamide
4tju
Crystal structure of human tankyrase 2 in complex with 3,4-c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (197 residues) CATH domain: Unassigned
Bound ligand:   Het Group CNQ is 45.00% similar to enzyme product nicotinamide
4tjw
Crystal structure of human tankyrase 2 in complex with pj-34
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (199 residues) CATH domain: Unassigned
4tjy
Crystal structure of human tankyrase 2 in complex with abt-8
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (199 residues) CATH domain: Unassigned
Bound ligand:   Het Group 3GN is 50.00% similar to enzyme product nicotinamide
4tk0
Crystal structure of human tankyrase 2 in complex with dpq.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (199 residues) CATH domain: Unassigned
4tk5
Crystal structure of human tankyrase 2 in complex with eb47.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (201 residues) CATH domain: Unassigned
4tkf
Crystal structure of human tankyrase 2 in complex with iwr-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (199 residues) CATH domain: Unassigned
Bound ligand:   Het Group 3AB is 72.73% similar to enzyme product nicotinamide
4tkg
Crystal structure of human tankyrase 2 in complex with azd22
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (200 residues) CATH domain: Unassigned
4tki
Crystal structure of human tankyrase 2 in complex with bsi-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnks2, parp5b, tank2, tnkl. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (199 residues) CATH domain: Unassigned
Bound ligand:   Het Group 33E is 57.14% similar to enzyme product nicotinamide
5ail
Human parp9 2nd macrodomain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (180 residues)