_EC 2.4.2.2 Pyrimidine-nucleoside phosphorylase. 2 PDB entries  
EC 2.-.-.- Transferases. [19,007 PDB entries]
EC 2.4.-.- Glycosyltransferases. [2,007 PDB entries]
EC 2.4.2.- Pentosyltransferases. [947 PDB entries]
EC 2.4.2.2 Pyrimidine-nucleoside phosphorylase. [2 PDB entries]    
1brw

Reaction: (1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.
 


Uridine
+
phosphate
=
uracil
+
alpha-D-ribose 1-phosphate

Thymidine
+
phosphate
=
thymine
+
2-deoxy-alpha-D-ribose 1-phosphate

2'-deoxyuridine
+
phosphate
=
uracil
+
2-deoxy-alpha-D-ribose 1-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Py-NPase.
Comments: Unlike Ec 2.4.2.3, and Ec 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction. Formerly Ec 2.4.2.23.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.2.4.2.2

  PDB code Protein
1brw
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation
Source: Geobacillus stearothermophilus. Organism_taxid: 1422
Chains: A, B (433 residues) CATH domains: 3.90.1170.30 3.40.1030.10 1.20.970.10
Bound ligands:   Het Group PO4 corresponds to enzyme reactant phosphate
  Het Group URA is 75.00% similar to enzyme product pyrimidine base
3h5q
Crystal structure of a putative pyrimidine-nucleoside phosph from staphylococcus aureus
Source: Staphylococcus aureus. Organism_taxid: 93062. Strain: col. Gene: pdp, pyn, sacol2128. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (436 residues) CATH domains: 1.20.970.10 3.40.1030.10 3.90.1170.30
Bound ligand:   Het Group THM is 77.78% similar to enzyme reactant pyrimidine