_EC 2.4.2.19 Nicotinate-nucleotide diphosphorylase (carboxylating). 21 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.4.-.- Glycosyltransferases. [1,918 PDB entries]
EC 2.4.2.- Pentosyltransferases. [897 PDB entries]
EC 2.4.2.19 Nicotinate-nucleotide diphosphorylase (carboxylating). [21 PDB entries]    
1o4u

Reaction: Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
 


Beta-nicotinate D-ribonucleotide
+
diphosphate
+
CO(2)
=
pyridine-2,3- dicarboxylate
+
5-phospho-alpha-D-ribose 1-diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Nicotinate-nucleotide pyrophosphorylase (carboxylating). Quinolinate phosphoribosyltransferase (decarboxylating).
Comments: The reaction is catalyzed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 21 PDB entries in enzyme class E.C.2.4.2.19

  PDB code Protein
1o4u
Crystal structure of a nicotinate nucleotide pyrophosphoryla (tm1645) from thermotoga maritima at 2.50 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm1645. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domains: 3.90.1170.20 3.20.20.70
1qap
Quinolinic acid phosphoribosyltransferase with bound quinolinic acid
Source: Salmonella typhimurium. Organism_taxid: 602. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (289 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group NTM corresponds to enzyme product pyridine-2,3- dicarboxylate
1qpn
Quinolinate phosphoribosyl transferase from mycobacterium tu in complex with ncnn
Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Gene: nadc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (284 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group NCN corresponds to enzyme reactant Nicotinate
1qpo
Quinolinate phosphoribosyl transferase (qaprtase) apo-enzyme mycobacterium tuberculosis
Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Gene: nadc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (284 residues) CATH domains: 3.90.1170.20 3.20.20.70
1qpq
Structure of quinolinic acid phosphoribosyltransferase from mycobacterium tuberculosis: a potential tb drug target
Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Gene: nadc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (284 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group NTM corresponds to enzyme product pyridine-2,3-
1qpr
Quinolinate phosphoribosyltransferase (qaprtase) from mycobacterium tuberculosis in complex with phthalate and prpcp
Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Cell_line: bl21. Gene: nadc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (284 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligands:   Het Group PHT is 84.00% similar to enzyme product pyridine-2,3- dicarboxylate
  Het Group PPC is 62.00% similar to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
2b7n
Crystal structure of quinolinic acid phosphoribosyltransfera helicobacter pylori
Source: Helicobacter pylori. Organism_taxid: 210. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (273 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group NTM corresponds to enzyme product pyridine-2,3-
2b7p
Crystal structure of quinolinic acid phosphoribosyltransfera helicobacter pylori
Source: Helicobacter pylori. Organism_taxid: 210. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (273 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group PHT is 84.62% similar to enzyme product pyridine-2,3-
2b7q
Crystal structure of quinolinic acid phosphoribosyltransfera helicobacter pylori
Source: Helicobacter pylori. Organism_taxid: 210. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (273 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group NCN corresponds to enzyme reactant Nicotinate
2jbm
Qprtase structure from human
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (290 residues) CATH domain: 3.90.1170.20
Bound ligand:   Het Group SRT is 57.00% similar to enzyme product pyridine-2,3- dicarboxylate
3c2e
Crystal structure at 1.9a of the apo quinolinate phosphoribosyl transferase (bna6) from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: bna6, qpt1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (267 residues) CATH domains: 3.90.1170.20 3.20.20.70
3c2f
Crystal structure of the quinolinate phosphoribosyl transferase (bna6) from saccharomyces cerevisiae complexed with prpp
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: bna6, qpt1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (267 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
3c2o
Crystal structure of the quinolinate phosphoribosyl transferase (bna6) from sachharomyces cerevisiae complexed with quinolinate
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: bna6, qpt1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (265 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group NTM corresponds to enzyme product pyridine-2,3- dicarboxylate
3c2r
Crystal structure of the quinolinate phosphoribosyl transferase (bna6) from sachharomyces cerevisiae complexed with the inhibitor phthalate
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: bna6, qpt1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (267 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group PHT is 84.00% similar to enzyme product pyridine-2,3- dicarboxylate
3c2v
Crystal structure of the quinolinate phosphoribosyl transferase (bna6) from saccharomyces cerevisiae complexed with prpp and the inhibitor phthalate
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: bna6, qpt1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (270 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligands:   Het Group PHT is 84.00% similar to enzyme product pyridine-2,3- dicarboxylate
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
3gnn
Crystal structure of nicotinate-nucleotide pyrophosphorylase from burkholderi pseudomallei
Source: Burkholderia pseudomallei. Organism_taxid: 320372. Strain: 1710b. Gene: nadc, burps1710b_1132. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (266 residues) CATH domain: 3.90.1170.20
Bound ligand:   Het Group UNK is 41.00% similar to enzyme product pyridine-2,3- dicarboxylate
3l0g
Crystal structure of nicotinate-nucleotide pyrophosphorylase ehrlichia chaffeensis at 2.05a resolution
Source: Ehrlichia chaffeensis. Organism_taxid: 205920. Strain: arkansas. Gene: nadc, ech_0026. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (272 residues) CATH domains: 3.90.1170.20 3.20.20.70
Bound ligand:   Het Group EDO is 40.00% similar to enzyme reactant CO(2)
3lar
Crystal structure of human quinolinate phosphoribosyltransfe
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qprt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (289 residues) CATH domain: 3.90.1170.20
3tqv
Structure of the nicotinate-nucleotide pyrophosphorylase fro francisella tularensis.
Source: Francisella tularensis subsp. Tularens organism_taxid: 177416. Strain: schu s4. Gene: nadc, ftt_1468c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (276 residues) CATH domain: 3.90.1170.20
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4kwv
Crystal structure of human apo-qprt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qprt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (285 residues) CATH domain: 3.90.1170.20
4kww
The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor pht
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: qprt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (285 residues) CATH domain: 3.90.1170.20
Bound ligand:   Het Group PHT is 84.62% similar to enzyme product pyridine-2,3-