_EC 2.4.2.12 Nicotinamide phosphoribosyltransferase. 53 PDB entries  
EC 2.-.-.- Transferases. [18,231 PDB entries]
EC 2.4.-.- Glycosyltransferases. [1,954 PDB entries]
EC 2.4.2.- Pentosyltransferases. [927 PDB entries]
EC 2.4.2.12 Nicotinamide phosphoribosyltransferase. [53 PDB entries]    
2e5b

Reaction: Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.
 


Nicotinamide D-ribonucleotide
+
diphosphate
=
nicotinamide
+
5-phospho- alpha-D-ribose 1-diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Nmn diphosphorylase. Nmn pyrophosphorylase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 53 PDB entries in enzyme class E.C.2.4.2.12

  PDB code Protein
2e5b
Crystal structure of human nmprtase as free-form
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (466 residues) CATH domains: Unassigned Unassigned
2e5c
Crystal structure of human nmprtase complexed with 5'-phosph 1'-pyrophosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (466 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose
2e5d
Crystal structure of human nmprtase complexed with nicotinam
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (466 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group NCA corresponds to enzyme product nicotinamide
2g95
Crystal structure of visfatin/pre-b cell colony enhancing factor 1/nicotinamide phosphoribosyltransferase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (456 residues) CATH domains: Unassigned Unassigned
2g96
Crystal structure of visfatin/pre-b cell colony enhancing factor 1/nicotinamide phosphoribosyltransferase in complex with niconamide mononucleotide
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (463 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group NMN corresponds to enzyme reactant Nicotinamide D-ribonucleotide
2g97
Crystal structure of visfatin/pre-b cell colony enhancing factor 1/nicotinamide phosphoribosyltransferase in complex with the specific inhibitor fk-866
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (463 residues) CATH domains: Unassigned Unassigned
2gvg
Crystal structure of human nmprtase and its complex with nmn
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (461 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group NMN corresponds to enzyme reactant Nicotinamide D-ribonucleotide
  Het Group PO4 is 55.00% similar to enzyme reactant diphosphate
2gvj
Crystal structure of human nmprtase in complex with fk866
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (465 residues) CATH domains: Unassigned Unassigned
2gvl
Crystal structure of murine nmprtase
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: nampt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (464 residues) CATH domains: Unassigned Unassigned
2h3b
Crystal structure of mouse nicotinamide phosphoribosyltransferase/visfatin/pre-b cell colony enhancing factor 1
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: nampt, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (466 residues) CATH domains: Unassigned Unassigned
2h3d
Crystal structure of mouse nicotinamide phosphoribosyltransferase/visfatin/pre-b cell colony enhancing factor in complex with nicotinamide mononuleotide
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: nampt, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (465 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group NMN corresponds to enzyme reactant Nicotinamide D-ribonucleotide
3dgr
Crystal structure of human nampt complexed with adp analogue
Source: Homo sapiens. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group A12 is 58.00% similar to enzyme reactant Nicotinamide D-ribonucleotide
3dhd
Crystal structure of human nampt complexed with nicotinamide mononucleotide and pyrophosphate
Source: Homo sapiens. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group NMN corresponds to enzyme reactant Nicotinamide D-ribonucleotide
  Het Group POP corresponds to enzyme reactant diphosphate
3dhf
Crystal structure of phosphorylated mimic form of human nampt complexed with nicotinamide mononucleotide and pyrophosphate
Source: Homo sapiens. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group NMN corresponds to enzyme reactant Nicotinamide D-ribonucleotide
  Het Group POP corresponds to enzyme reactant diphosphate
3dkj
Crystal structure of human nampt complexed with benzamide and phosphoribosyl pyrophosphate
Source: Homo sapiens. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group UNU is 80.00% similar to enzyme product nicotinamide
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
3dkl
Crystal structure of phosphorylated mimic form of human nampt complexed with benzamide and phosphoribosyl pyrophosphate
Source: Homo sapiens. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group UNU is 80.00% similar to enzyme product nicotinamide
  Het Group PRP corresponds to enzyme product 5-phospho-alpha-D-ribose 1-diphosphate
3g8e
Crystal structure of rattus norvegicus visfatin/pbef/nampt in complex with an fk866-based inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: visfatin. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (463 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group IS1 is 42.00% similar to enzyme reactant Nicotinamide D-ribonucleotide
4jnm
Discovery of potent and efficacious urea-containing nicotina phosphoribosyltransferase (nampt) inhibitors with reduced c inhibition properties
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4jr5
Structure-based identification of ureas as novel nicotinamid phosphoribosyltransferase (nampt) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4kfn
Structure-based discovery of novel amide-containing nicotina phosphoribosyltransferase (nampt) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (473 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4kfo
Structure-based discovery of novel amide-containing nicotina phosphoribosyltransferase (nampt) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (472 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4kfp
Identification of 2,3-dihydro-1h-pyrrolo[3,4-c]pyridine-deri as potent inhibitors of human nicotinamide phosphoribosyltr (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4l4l
Structural analysis of a phosphoribosylated inhibitor in com human nicotinamide phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (472 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group 1XC is 41.30% similar to enzyme reactant Nicotinamide
  Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4l4m
Structural analysis of a phosphoribosylated inhibitor in com human nicotinamide phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4lts
Discovery of potent and efficacious cyanoguanidine-containin nicotinamide phosphoribosyltransferase (nampt) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (472 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4lv9
Fragment-based identification of amides derived from trans-2 3-yl)cyclopropanecarboxylic acid as potent inhibitors of hu nicotinamide phosphoribosyltransferase (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
  Het Group 20J is 43.75% similar to enzyme product nicotinamide
4lva
Fragment-based identification of amides derived from trans-2 3-yl)cyclopropanecarboxylic acid as potent inhibitors of hu nicotinamide phosphoribosyltransferase (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4lvb
Fragment-based identification of amides derived from trans-2 3-yl)cyclopropanecarboxylic acid as potent inhibitors of hu nicotinamide phosphoribosyltransferase (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group 20N is 40.74% similar to enzyme reactant Nicotinamide
  Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4lvd
Fragment-based identification of amides derived from trans-2 3-yl)cyclopropanecarboxylic acid as potent inhibitors of hu nicotinamide phosphoribosyltransferase (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: B, A (469 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group 1EB is 42.31% similar to enzyme reactant Nicotinamide
  Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4lvf
Fragment-based identification of amides derived from trans-2 3-yl)cyclopropanecarboxylic acid as potent inhibitors of hu nicotinamide phosphoribosyltransferase (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
  Het Group 20P is 42.11% similar to enzyme product nicotinamide
4lvg
Fragment-based identification of amides derived from trans-2 3-yl)cyclopropanecarboxylic acid as potent inhibitors of hu nicotinamide phosphoribosyltransferase (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4lww
Discovery of potent and efficacious cyanoguanidine-containin nicotinamide phosphoribosyltransferase (nampt) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4m6p
Identification of amides derived from 1h-pyrazolo[3,4-b]pyri carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (472 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4m6q
Identification of amides derived from 1h-pyrazolo[3,4-b]pyri carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (nampt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group 20T is 48.89% similar to enzyme reactant Nicotinamide
  Het Group POP corresponds to enzyme reactant diphosphate
4n9b
Fragment-based design of 3-aminopyridine-derived amides as p inhibitors of human nicotinamide phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
  Het Group 2HH is 41.18% similar to enzyme product nicotinamide
4n9c
Fragment-based design of 3-aminopyridine-derived amides as p inhibitors of human nicotinamide phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
  Het Group 2ZM is 61.54% similar to enzyme product nicotinamide
4n9d
Fragment-based design of 3-aminopyridine-derived amides as p inhibitors of human nicotinamide phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4n9e
Fragment-based design of 3-aminopyridine-derived amides as p inhibitors of human nicotinamide phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o0z
Structural and biochemical analyses of the catalysis and pot impact of inhibitor phosphoribosylation by human nicotinami phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o10
Structural and biochemical analyses of the catalysis and pot impact of inhibitor phosphoribosylation by human nicotinami phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o12
Structural and biochemical analyses of the catalysis and pot impact of inhibitor phosphoribosylation by human nicotinami phosphoribosyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (472 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o13
The crystal structure of nampt in complex with gne-618
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o14
Structural basis for resistance to diverse classes of nampt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (469 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o15
The crystal structure of a mutant nampt (s165f) in complex w 618
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (465 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o16
Structural basis for resistance to diverse classes of nampt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (470 residues)
Bound ligands:   Het Group 1XC is 41.30% similar to enzyme reactant Nicotinamide
  Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o17
Structural basis for resistance to diverse classes of nampt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (467 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o18
Structural basis for resistance to diverse classes of nampt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o19
The crystal structure of a mutant nampt (g217v)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o1a
The crystal structure of the mutant nampt g217r
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o1b
The crystal structure of a mutant nampt (g217r) in complex w inhibitor apo866
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o1c
The crystal structures of a mutant nampt h191r
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o1d
Structural basis for resistance to diverse classes of nampt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (471 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate
4o28
Structural basis for resistance to diverse classes of nampt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nampt, pbef, pbef1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (465 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme reactant diphosphate