_EC 2.4.1.41 Polypeptide N-acetylgalactosaminyltransferase. 8 PDB entries  
EC 2.-.-.- Transferases. [17,769 PDB entries]
EC 2.4.-.- Glycosyltransferases. [1,909 PDB entries]
EC 2.4.1.- Hexosyltransferases. [934 PDB entries]
EC 2.4.1.41 Polypeptide N-acetylgalactosaminyltransferase. [8 PDB entries]    
1xhb

Reaction: UDP-N-acetyl-alpha-D-galactosamine + polypeptide = Udp + N-acetyl-alpha- D-galactosaminyl-polypeptide.
 

UDP-N-acetyl-alpha-D-galactosamine
+
polypeptide
=
UDP
+ N-acetyl-alpha- D-galactosaminyl-polypeptide
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Protein-UDP acetylgalactosaminyltransferase.
Cofactor(s): Calcium; Manganese.
Comments: The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 8 PDB entries in enzyme class E.C.2.4.1.41

  PDB code Protein
1xhb
The crystal structure of udp-galnac: polypeptide alpha-n- acetylgalactosaminyltransferase-t1
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: galnt1. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (447 residues) CATH domains: Unassigned Unassigned 2.80.10.50
Bound ligand:   Het Group NAG is 44.44% similar to enzyme product UDP
2d7i
Crsytal structure of pp-galnac-t10 with udp, galnac and mn2+
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (536 residues) CATH domains: Unassigned 2.80.10.50
Bound ligand:   Het Group UDP corresponds to enzyme product UDP
2d7r
Crystal structure of pp-galnac-t10 complexed with galnac-ser domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (536 residues) CATH domains: Unassigned 2.80.10.50
Bound ligand:   Het Group UDP corresponds to enzyme product UDP
2ffu
Crystal structure of human ppgalnact-2 complexed with udp and ea2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: galnt2. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Other_details: invitrogen ppic9 vector with tev-protease- cleavable, n-terminal engineered 6his tag. Synthetic: yes.
Chain: A (494 residues) CATH domains: Unassigned 2.80.10.50
Bound ligand:   Het Group UDP corresponds to enzyme product UDP
2ffv
Human ppgalnact-2 complexed with manganese and udp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: galnt2. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Other_details: invitrogen ppic9 vector with tev-protease-cl n-terminal engineered 6his tag
Chains: A, B (489 residues) CATH domains: Unassigned 2.80.10.50
Bound ligand:   Het Group UDP corresponds to enzyme product UDP
4d0t
Galnac-t2 crystal soaked with udp-galnac, ea2 peptide and manganese
Source: Synthetic construct. Organism_taxid: 32630. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.
Chains: A, B, C, D, E, F (496 residues) CATH domains: Unassigned 2.80.10.50
Bound ligand:   Het Group UD2 is 64.10% similar to enzyme product UDP
4d0z
Galnac-t2 crystal soaked with udp-5sgalnac, mea2 and manganese (higher resolution dataset)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.
Chains: A, B, C, D, E, F (495 residues) CATH domains: Unassigned 2.80.10.50
Bound ligand:   Het Group HWU is 64.10% similar to enzyme product UDP
4d11
Galnac-t2 crystal soaked with udp-5sgalnac, mea2 peptide and manganese (lower resolution dataset)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.
Chains: A, B, C, D, E, F (491 residues)
Bound ligand:   Het Group UDP corresponds to enzyme product UDP