_EC 2.4.1.224 Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- 0 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.4.-.- Glycosyltransferases. [1,918 PDB entries]
EC 2.4.1.- Hexosyltransferases. [944 PDB entries]
EC 2.4.1.224 Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- [-]    

Pathway: Heparan Biosynthesis
(later stages)
Reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-proteoglycan = Udp + N-acetyl-alpha-D-glucosaminyl-(1->4)- beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.
 


UDP-N-acetyl-D-glucosamine
+ beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-proteoglycan
=
UDP
+ N-acetyl-alpha-D-glucosaminyl-(1->4)- beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Alpha-N-acetylglucosaminyltransferase Ii. Glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase.
Comments: Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the enzyme from human (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the Ec 2.4.1.225 activity required for the synthesis of the heparan sulfate disaccharide repeats. Other human forms of this enzyme (e.g. the product of the EXTL1 gene) have only the 4-alpha-N-acetylglucosaminyltransferase activity. In Caenorhabditis elegans, the product of the rib-2 gene displays the activities of this enzyme as well as Ec 2.4.1.223.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.2.4.1.224