_EC 2.4.1.14 Sucrose-phosphate synthase. 2 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.4.-.- Glycosyltransferases. [1,920 PDB entries]
EC 2.4.1.- Hexosyltransferases. [944 PDB entries]
EC 2.4.1.14 Sucrose-phosphate synthase. [2 PDB entries]    
2r66

Reaction: UDP-glucose + D-fructose 6-phosphate = Udp + sucrose 6(F)-phosphate.
 


UDP-glucose
+
D-fructose 6-phosphate
=
UDP
+
sucrose 6(F)-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Sucrosephosphate--UDP glucosyltransferase. UDP-glucose-fructose-phosphate glucosyltransferase.
Cofactor(s): Mn(2+) or Mg(2+).
Comments: The enzyme from Synechocystis sp. strain Pcc 6803 is not specific for UDP-glucose as it can use ADP-glucose and, to a lesser extent, GDP- glucose as substrates. The enzyme from rice leaves is activated by glucose 6-phosphate but that from cyanobacterial species is not. While the reaction catalyzed by this enzyme is reversible, the enzyme usually works in concert with Ec 3.1.3.24 to form sucrose, making the above reaction essentially irreversible. The F in sucrose 6(F)-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.2.4.1.14

  PDB code Protein
2r66
Complex structure of sucrose phosphate synthase (sps)-f6p of halothermothrix orenii
Source: Halothermothrix orenii. Organism_taxid: 373903. Strain: h 168. Gene: sps. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (456 residues) CATH domains: Unassigned 3.40.50.2000
Bound ligand:   Het Group F6P corresponds to enzyme reactant D-fructose 6-phosphate
2r68
Complex structure of sucrose phosphate synthase (sps)-s6p of halothermothrix orenii
Source: Halothermothrix orenii. Organism_taxid: 373903. Strain: h 168. Gene: sps. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (456 residues) CATH domains: Unassigned 3.40.50.2000
Bound ligand:   Het Group SUP corresponds to enzyme product sucrose