_EC 2.3.3.9 Malate synthase. 13 PDB entries  
EC 2.-.-.- Transferases. [16,702 PDB entries]
EC 2.3.-.- Acyltransferases. [1,114 PDB entries]
EC 2.3.3.- Acyl groups converted into alkyl on transfer. [81 PDB entries]
EC 2.3.3.9 Malate synthase. [13 PDB entries]    
1d8c

Pathway: Glyoxylate Cycle
Reaction: Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA.
 


Acetyl-CoA
+ H(2)O
+
glyoxylate
=
(S)-malate
+
CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Glyoxylate transacetase. Glyoxylate transacetylase. Glyoxylic transacetase. L-malate glyoxylate-lyase (CoA-acetylating). Malate condensing enzyme. Malate synthetase. Malic synthetase. Malic-condensing enzyme.
Comments: Formerly Ec 4.1.3.2.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 13 PDB entries in enzyme class E.C.2.3.3.9

  PDB code Protein
1d8c
Malate synthase g complexed with magnesium and glyoxylate
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (709 residues) CATH domains: 1.10.1860.10 2.170.170.11 3.20.20.360 1.20.1220.12
Bound ligands:   Het Group GLV corresponds to enzyme reactant Acetyl-CoA
  Het Group SOR is 50.00% similar to enzyme product
1n8i
Biochemical and structural studies of malate synthase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: glcb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (701 residues) CATH domains: 1.10.1860.10 2.170.170.11 3.20.20.360 1.20.1220.12
Bound ligand:   Het Group GLV corresponds to enzyme reactant Acetyl-CoA
1n8w
Biochemical and structural studies of malate synthase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: glcb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (718 residues) CATH domains: 1.10.1860.10 2.170.170.11 3.20.20.360 1.20.1220.12
Bound ligands:   Het Group COA is 94.00% similar to enzyme reactant Acetyl-CoA
  Het Group MLT corresponds to enzyme product
1p7t
Structure of escherichia coli malate synthase g:pyruvate:ace coenzyme a abortive ternary complex at 1.95 angstrom resolu
Source: Escherichia coli str. K12 substr.. Organism_taxid: 316407. Strain: w3110. Gene: glcb or glc or b2976. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (706 residues) CATH domains: 1.10.1860.10 2.170.170.11 3.20.20.360 1.20.1220.12
Bound ligands:   Het Group ACO corresponds to enzyme reactant Acetyl-CoA
  Het Group PYR is 83.33% similar to enzyme reactant
1y8b
Solution nmr-derived global fold of malate synthase g from e.Coli
Source: Escherichia coli. Organism_taxid: 562. Gene: glcb, glc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (723 residues) CATH domains: 1.10.1860.10 3.20.20.360 2.170.170.11 1.20.1220.12
2gq3
Mycobacterium tuberculosis malate synthase in complex with m malate, and coenzyme a
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: glcb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (720 residues) CATH domains: 1.10.1860.10 3.20.20.360 2.170.170.11 1.20.1220.12
Bound ligands:   Het Group MLT corresponds to enzyme product Acetyl-CoA
  Het Group COA corresponds to enzyme product
2jqx
Solution structure of malate synthase g from joint refinement against nmr and saxs data
Source: Escherichia coli. Organism_taxid: 562. Gene: glcb, glc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (723 residues) CATH domains: 1.10.1860.10 3.20.20.360 2.170.170.11 1.20.1220.12
3s9i
Crystal structure of mycobacterium tuberculosis malate synth complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: glcb, mt1885, mtcy1a11.06, rv1837c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (714 residues) CATH domains: 1.10.1860.10 3.20.20.360 2.170.170.11 1.20.1220.12
Bound ligand:   Het Group XI7 is 53.33% similar to enzyme product Acetyl-CoA
3s9z
Crystal structure of mycobacterium tuberculosis malate synth complex with 4-(2-bromophenyl)-2,4-dioxobutanoic acid inhib
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: glcb, glcb (rv1837c), mt1885, mtcy1a11.06, rv1837c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (715 residues) CATH domains: 1.10.1860.10 3.20.20.360 2.170.170.11 1.20.1220.12
Bound ligand:   Het Group I92 is 50.00% similar to enzyme product Acetyl-CoA
3sad
Crystal structure of mycobacterium tuberculosis malate synth complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhi
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: glcb, rv1837c, mt1885, mtcy1a11.06. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (709 residues) CATH domains: 1.10.1860.10 3.20.20.360 2.170.170.11 1.20.1220.12
Bound ligand:   Het Group 040 is 50.00% similar to enzyme product Acetyl-CoA
3saz
Crystal structure of mycobacterium tuberculosis malate synth complex with 4-(3-bromophenyl)-2,4-dioxobutanoic acid inhib
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: glcb, glcb (rv1837c), mt1885, mtcy1a11.06, rv1837c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (712 residues) CATH domains: 1.10.1860.10 3.20.20.360 2.170.170.11 1.20.1220.12
Bound ligand:   Het Group 043 is 50.00% similar to enzyme product Acetyl-CoA
3sb0
Crystal structure of mycobacterium tuberculosis malate synth complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxo acid inhibitor
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: glcb, glcb (rv1837c), mt1885, mtcy1a11.06, rv1837c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (708 residues) CATH domains: 1.10.1860.10 3.20.20.360 2.170.170.11 1.20.1220.12
Bound ligand:   Het Group I93 is 44.44% similar to enzyme product Acetyl-CoA
4ex4
The structure of glcb from mycobacterium leprae
Source: Mycobacterium leprae. Organism_taxid: 561304. Strain: br4923. Gene: glcb, ml2069, mlbr02069, mlcb1788.27. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (684 residues) CATH domains: 1.10.1860.10 3.20.20.360 Unassigned 1.20.1220.12
Bound ligand:   Het Group EDO is 80.00% similar to enzyme reactant Acetyl-CoA