_EC Cyclo(L-tyrosyl-L-tyrosyl) synthase. 1 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.3.-.- Acyltransferases. [1,208 PDB entries]
EC 2.3.2.- Aminoacyltransferases. [114 PDB entries]
EC Cyclo(L-tyrosyl-L-tyrosyl) synthase. [1 PDB entries]    

Reaction: 2 L-tyrosyl-tRNA(Tyr) = 2 tRNA(Tyr) + cyclo(L-tyrosyl-L-tyrosyl).

2 × L-tyrosyl-tRNA(Tyr)
2 × tRNA(Tyr)
+ cyclo(L-tyrosyl-L-tyrosyl)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Cyclodityrosine synthase.
Comments: The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl).
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There are 1 PDB entries in enzyme class E.C.

  PDB code Protein
Structure of the mycobacterium tuberculosis protein, rv2275, demonstrates that cyclodipeptide synthetases are related to type i tRNA-synthetases.
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (231 residues) CATH domain: Unassigned