_EC 2.3.2.2 Gamma-glutamyltransferase. 19 PDB entries  
EC 2.-.-.- Transferases. [17,769 PDB entries]
EC 2.3.-.- Acyltransferases. [1,202 PDB entries]
EC 2.3.2.- Aminoacyltransferases. [116 PDB entries]
EC 2.3.2.2 Gamma-glutamyltransferase. [19 PDB entries]    
2dbu

Reaction: A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
 


(5-L-glutamyl)-peptide
+
amino acid
=
peptide
+
5-L-glutamyl amino acid
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Gamma-glutamyl transpeptidase. Gamma-glutamyltranspeptidase. Glutamyl transpeptidase.
Comments: The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular Gsh levels. The protein also has Ec 3.4.19.13 activity. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 19 PDB entries in enzyme class E.C.2.3.2.2

  PDB code Protein
2dbu
Crystal structure of gamma-glutamyltranspeptidase from escherichia coli
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: ggt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (359 residues) CATH domains: Unassigned Unassigned
2dbw
Crystal structure of gamma-glutamyltranspeptidase from esche coli acyl-enzyme intermediate
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: ggt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (359 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group GGL is 60.00% similar to enzyme product 5-L-glutamyl
2dbx
Crystal structure of gamma-glutamyltranspeptidase from esche coli complexed with l-glutamate
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: ggt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (351 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group GLU is 56.25% similar to enzyme product 5-L-glutamyl
2dg5
Crystal structure of gamma-glutamyl transpeptidase from esch coli in complex with hydrolyzed glutathione
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: ggt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (351 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group GLU is 56.25% similar to enzyme product 5-L-glutamyl
2e0w
T391a precursor mutant protein of gamma-glutamyltranspeptida escherichia coli
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: ggt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (496 residues) CATH domains: Unassigned Unassigned
2e0x
Crystal structure of gamma-glutamyltranspeptidase from escherichia coli (monoclinic form)
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: ggt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (359 residues) CATH domains: Unassigned Unassigned
2e0y
Crystal structure of the samarium derivative of mature gamma glutamyltranspeptidase from escherichia coli
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: ggt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (359 residues) CATH domains: Unassigned Unassigned
2v36
Crystal structure of gamma-glutamyl transferase from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: bl21.
Chains: A, B, C, D (359 residues) CATH domains: Unassigned Unassigned
2z8i
Crystal structure of escherichia coli gamma-glutamyltranspep complex with azaserine
Source: Escherichia coli. Organism_taxid: 562. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (350 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group AZS is 45.45% similar to enzyme reactant amino
  Het Group AZS is 42.86% similar to enzyme product L-glutamate
2z8j
Crystal structure of escherichia coli gamma-glutamyltranspep complex with azaserine prepared in the dark
Source: Escherichia coli. Organism_taxid: 562. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (350 residues) CATH domains: Unassigned Unassigned
2z8k
Crystal structure of escherichia coli gamma-glutamyltranspep complex with acivicin
Source: Escherichia coli. Organism_taxid: 562. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (350 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group AVN is 56.25% similar to enzyme product 5-L-glutamyl
  Het Group AVN is 66.67% similar to enzyme product L-glutamate
3a75
Crystal structure of glutamate complex of halotolerant γ-glutamyltranspeptidase from bacillus subtilis
Source: Bacillus subtilis. Organism_taxid: 1423. Strain: 168. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (359 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group GLU is 56.00% similar to enzyme product 5-L-glutamyl amino acid
3whq
Crystal structure of gamma-glutamyltranspeptidase from bacil subtilis (crystal soaked for 0 min. In acivicin soln. )
Source: Bacillus subtilis. Organism_taxid: 224308. Strain: 168. Gene: ggt, bsu18410. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (360 residues) CATH domains: Unassigned Unassigned
3whr
Crystal structure of gamma-glutamyltranspeptidase from bacil subtilis (crystal soaked for 3min. In acivicin soln. )
Source: Bacillus subtilis. Organism_taxid: 224308. Strain: 168. Gene: ggt, bsu18410. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (359 residues) CATH domains: Unassigned Unassigned
3whs
Crystal structure of bacillus subtilis gamma-glutamyltranspe complex with acivicin
Source: Bacillus subtilis. Organism_taxid: 224308. Strain: 168. Gene: ggt, bsu18410. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (359 residues) CATH domains: Unassigned Unassigned
4gdx
Crystal structure of human gamma-glutamyl transpeptidase--gl complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ggt, ggt1. Expressed in: pichia. Expression_system_taxid: 4919. Expression_system_taxid: 4919
Chains: A, B (342 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group GLU is 83.33% similar to enzyme reactant amino
  Het Group NAG is 45.00% similar to enzyme product 5-L-glutamyl
4gg2
The crystal structure of glutamate-bound human gamma- glutamyltranspeptidase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ggt, ggt1, hggt1. Expressed in: pichia. Expression_system_taxid: 4919. Expression_system_taxid: 4919
Chains: A, B (343 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group GLU is 83.33% similar to enzyme reactant amino
  Het Group NAG is 45.00% similar to enzyme product 5-L-glutamyl
4ott
Crystal structure of the gamma-glutamyltranspeptidase from b licheniformis.
Source: Bacillus licheniformis. Organism_taxid: 1402. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 279010. Strain: dsm 13 / atcc 14580. Gene: ggt, bl03798, bli01364. Expression_system_taxid: 562
Chains: A, B (357 residues)
4otu
Crystal structure of the gamma-glutamyltranspeptidase from b licheniformis in complex with l-glutamate
Source: Bacillus licheniformis. Organism_taxid: 1402. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 279010. Gene: ggt, bl03798, bli01364. Expression_system_taxid: 562
Chains: A, B (363 residues)
Bound ligand:   Het Group GLU is 56.25% similar to enzyme product 5-L-glutamyl