_EC 2.3.2.13 Protein-glutamine gamma-glutamyltransferase. 31 PDB entries  
EC 2.-.-.- Transferases. [17,781 PDB entries]
EC 2.3.-.- Acyltransferases. [1,185 PDB entries]
EC 2.3.2.- Aminoacyltransferases. [116 PDB entries]
EC 2.3.2.13 Protein-glutamine gamma-glutamyltransferase. [31 PDB entries]    
1bl2

Reaction: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
 


Protein glutamine
+
alkylamine
=
protein N(5)-alkylglutamine
+ NH(3)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Fibrinoligase. Glutaminylpeptide gamma-glutamyltransferase. Polyamine transglutaminase. TGase. Transglutaminase.
Cofactor(s): Calcium.
Comments: The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine crosslinks.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 31 PDB entries in enzyme class E.C.2.3.2.13

  PDB code Protein
1bl2
Human factor xiii with strontium bound in the ion site
Source: Homo sapiens. Human. Expressed in: saccharomyces cerevisiae
Chains: A, B (700 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1evu
Human factor xiii with calcium bound in the ion site
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chains: A, B (708 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1ex0
Human factor xiii, mutant w279f zymogen
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chains: A, B (705 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1f13
Recombinant human cellular coagulation factor xiii
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: placenta. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (722 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1fau
Building by homology of human tissue transglutaminase
Source: Homo sapiens. Human. Cell: endothelial
Chain: A (687 residues)
1fie
Recombinant human coagulation factor xiii
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: placenta. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (705 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1g0d
Crystal structure of red sea bream transglutaminase
Source: Pagrus major. Red seabream. Organism_taxid: 143350. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (666 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1ggt
Three-dimensional structure of a transglutaminase: human blood coagulation factor xiii
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood
Chains: A, B (710 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1ggu
Human factor xiii with calcium bound in the ion site
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (701 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1ggy
Human factor xiii with ytterbium bound in the ion site
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (702 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1iu4
Crystal structure analysis of the microbial transglutaminase
Source: Streptomyces mobaraensis. Organism_taxid: 35621. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (331 residues) CATH domain: 3.90.1360.10
1kv3
Human tissue transglutaminase in gdp bound form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (651 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1l9m
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: foreskin. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Pvl1392 (invitrogen).
Chains: A, B (675 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1l9n
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: foreskin. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Pvl1392 (invitrogen).
Chains: A, B (673 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1nud
Role of calcium ions in the activation and activity of the transglutaminase 3 enzyme (3 calciums, active form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. (Invitrogen).
Chains: A, B (673 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1nuf
Role of calcium ions in the activation and activity of the transglutaminase 3 enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. (Invitrogen).
Chain: A (675 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1nug
Role of calcium ions in the activation and activity of the transglutaminase 3 enzyme (2 calciums, 1 mg, inactive form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. (Invitrogen).
Chains: A, B (675 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1qrk
Human factor xiii with strontium bound in the ion site
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932
Chains: A, B (700 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1rle
Structural basis for the coordinated regulation of transglut by guanine nucleotides and calcium/magnesium
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: foreskin. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. (Invitrogen), bac-n-blue (invitrogen).
Chains: A, B (675 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1rll
Structural basis for the coordinated regulation of transglutaminase 3 by guanine nucleotides and calcium/magnesium
Source: Homo sapiens. Human. Tissue: foreskin. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_cell_line: sf9. Pvl1392 (invitrogen), bac-n-blue (invitrogen). Other_details: see reference 4 below
Chains: A, B (675 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1sgx
Crystal structure of transglutaminase 3 in complex with boun structural basis for alteration in nucleotide specificity
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: foreskin. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. (Invitrogen), bac-n-blue (invitrogen).
Chains: A, B (675 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
1vjj
Structural basis for the coordinated regulation of transglut by guanine nucleotides and calcium/magnesium
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: foreskin. Gene: tgm3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. (Invitrogen), bac-n-blue (invitrogen).
Chains: A, B (675 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
2q3z
Transglutaminase 2 undergoes large conformational change upo activation
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized.
Chain: A (655 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
Bound ligand:   Het Group ONL is 53.33% similar to enzyme reactant Protein
2xzz
Crystal structure of the human transglutaminase 1 beta-barre
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
Chain: A (97 residues) CATH domain: 2.60.40.10
3iu0
Structural basis for zymogen activation and substrate bindin transglutaminase from streptomyces mobaraense
Source: Streptomyces mobaraensis. Streptoverticillium mobaraense. Organism_taxid: 35621. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (354 residues) CATH domain: 3.90.1360.10
3ly6
Crystal structure of human transglutaminase 2 complex with a 5' triphosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (683 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
3s3j
Transglutaminase 2 in complex with a novel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
Chain: A (650 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
Bound ligand:   Het Group 02Y is 53.33% similar to enzyme reactant Protein
3s3p
Transglutaminase 2 in complex with a novel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
Chain: A (611 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
Bound ligand:   Het Group GLN is 64.29% similar to enzyme reactant Protein
3s3s
Transglutaminase 2 in complex with a novel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgm2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
Chain: A (620 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant Protein
3tw5
Crystal structure of the gp42 transglutaminase from phytopht
Source: Phytophthora sojae. Organism_taxid: 67593. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (344 residues) CATH domains: Unassigned Unassigned
4kty
Fibrin-stabilizing factor with a bound ligand
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f13a, f13a1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes
Chains: A, B (695 residues) CATH domains: 2.60.40.10 3.90.260.10 2.60.40.10 2.60.40.10
Bound ligands:   Het Group TRP is 40.00% similar to enzyme reactant Protein
  Het Group NLE is 43.75% similar to enzyme product protein