_EC 2.3.1.86 Fatty-acyl-CoA synthase. 6 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.3.-.- Acyltransferases. [1,204 PDB entries]
EC 2.3.1.- Transferring groups other than amino-acyl groups. [994 PDB entries]
EC 2.3.1.86 Fatty-acyl-CoA synthase. [6 PDB entries]    
2pff

Reaction: Acetyl-CoA + n malonyl-CoA + 2n Nadph = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+).
 


Acetyl-CoA
+
n malonyl-CoA
+ 2n NADPH
=
long-chain-acyl-CoA
+
n CoA
+
n CO(2)
+ 2n NADP(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Yeast fatty acid synthase.
Comments: The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi- functional protein complex composed of two subunits. One subunit catalyzes the reactions Ec 1.1.1.100 and Ec 2.3.1.41, while the other subunit catalyzes the reactions of Ec 2.3.1.38, Ec 2.3.1.39, Ec 4.2.1.59, Ec 1.3.1.10 and Ec 1.1.1.279. The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires Fmn as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.2.3.1.86

  PDB code Protein
2pff
Structural insights of yeast fatty acid synthase
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: yit613. Synthetic: yes
Chains: A, B, D, E, G, H (1683 residues)
2uv8
Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 angstrom resolution
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, G, H, I (1614 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned Unassigned Unassigned Unassigned
2vkz
Structure of the cerulenin-inhibited fungal fatty acid synthase type i multienzyme complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, G, H, I (1614 residues)
2was
Structure of the fungal type i fas ppt domain
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold.
Chains: A, B, C, D, E, F (113 residues) CATH domain: 3.90.470.20
2wat
Structure of the fungal type i fas ppt domain in complex with coa
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold.
Chains: A, B, C, D, E, F (121 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA is 94.00% similar to enzyme reactant acetyl-CoA
3hmj
Saccharomyces cerevisiae fas type i
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: fas2. Gene: fas1
Chains: A, B, C, G, H, I (1750 residues)