_EC 2.3.1.181 Lipoyl(octanoyl) transferase. 5 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.3.-.- Acyltransferases. [1,208 PDB entries]
EC 2.3.1.- Transferring groups other than amino-acyl groups. [998 PDB entries]
EC 2.3.1.181 Lipoyl(octanoyl) transferase. [5 PDB entries]    
1w66

Reaction: Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein].
 


Octanoyl-[acyl-carrier-protein]
+
protein
=
protein N(6)-(octanoyl)lysine
+
[acyl-carrier-protein]
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Lipoate/octanoate transferase. Lipoyl (octanoyl)-[acyl-carrier-protein]-protein N-lipoyltransferase. Lipoyl(octanoyl)transferase. Lipoyltransferase. Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
Comments: The first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E(2) domain), 2-oxoglutarate dehydrogenase (E(2) domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the true substrate.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.2.3.1.181

  PDB code Protein
1w66
Structure of a lipoate-protein ligase b from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (218 residues) CATH domain: 3.30.930.10
Bound ligand:   Het Group DKA is 64.00% similar to enzyme reactant Octanoyl-[acyl-carrier-protein]
2qhs
Structural basis of octanoic acid recognition by lipoate-pro ligase b
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: ttc 1746. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (210 residues) CATH domain: 3.30.930.10
Bound ligand:   Het Group OCA is 75.00% similar to enzyme reactant Octanoyl-[acyl-carrier-protein]
2qht
Structural basis of octanoic acid recognition by lipoate-pro ligase b
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: ttc 1746. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (210 residues) CATH domain: 3.30.930.10
2qhu
Structural basis of octanoic acid recognition by lipoate-pro ligase b
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: ttc 1746. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (210 residues) CATH domain: 3.30.930.10
Bound ligand:   Het Group OYA is 81.82% similar to enzyme reactant Octanoyl-[acyl-carrier-protein]
2qhv
Structural basis of octanoic acid recognition by lipoate-pro ligase b
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Gene: ttc 1746. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (210 residues) CATH domain: 3.30.930.10
Bound ligand:   Het Group OC9 is 81.82% similar to enzyme reactant Octanoyl-[acyl-carrier-protein]