_EC 2.3.1.176 Propanoyl-CoA C-acyltransferase. 3 PDB entries  
EC 2.-.-.- Transferases. [17,769 PDB entries]
EC 2.3.-.- Acyltransferases. [1,202 PDB entries]
EC 2.3.1.- Transferring groups other than amino-acyl groups. [992 PDB entries]
EC 2.3.1.176 Propanoyl-CoA C-acyltransferase. [3 PDB entries]    
1c44

Reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl- CoA.
 


3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA
+
propanoyl-CoA
=
CoA
+
3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl- CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Peroxisomal thiolase 2. PTE-2. SCP(chi). SCP-X. Sterol carrier protein-chi. Sterol carrier protein-X.
Comments: Also acts on dihydroxy-5-beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. Catalyzes the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO- SCoA) to either glycine or taurine (NH(2)R') by Ec 2.3.1.65.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 3 PDB entries in enzyme class E.C.2.3.1.176

  PDB code Protein
1c44
Sterol carrier protein 2 (scp2) from rabbit
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Organ: liver. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (123 residues) CATH domain: 3.30.1050.10
1qnd
Sterol carrier protein-2, nmr, 20 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Cellular_location: cytoplasmic. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 3.30.1050.10
2c0l
Tpr domain of human pex5p in complex with human mscp2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: B (122 residues) CATH domain: 3.30.1050.10