_EC 2.3.1.169 CO-methylating acetyl-CoA synthase. 7 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.3.-.- Acyltransferases. [1,208 PDB entries]
EC 2.3.1.- Transferring groups other than amino-acyl groups. [998 PDB entries]
EC 2.3.1.169 CO-methylating acetyl-CoA synthase. [7 PDB entries]    
1mjg

Reaction: Acetyl-CoA + corrinoid protein = Co + methylcorrinoid protein + CoA.
 


Acetyl-CoA
+
corrinoid protein
=
CO
+
methylcorrinoid protein
+
CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Acs.
Cofactor(s): Iron-sulfur; Ni(2+).
 

Iron-sulfur
Ni(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also catalyzes exchange reactions of carbon between C-1 of acetyl-CoA and Co, and between C-2 of acetyl-CoA and methyl corrinoid protein. Involved, together with Ec 1.2.7.4, in the synthesis of acetyl-CoA from CO(2) and H(2). To follow its stoichiometry, the reaction can be written as: CH(3)- CO-S-CoA + protein Co(+) + H(+) = Co + protein Co(2+)-CH(3) + HS-CoA.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.2.3.1.169

  PDB code Protein
1mjg
Crystal structure of bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs) from moorella thermoacetica (f. Clostridium thermoaceticum)
Source: Moorella thermoacetica. Organism_taxid: 1525. Organism_taxid: 1525
Chains: M, N, O, P (728 residues) CATH domains: 1.10.8.190 3.40.50.2030 3.30.1650.10 3.40.970.20 3.40.1470.10
Bound ligand:   Het Group ACT is 66.00% similar to enzyme product CO
1oao
Nizn[fe4s4] and nini[fe4s4] clusters in closed and open alpha subunits of acetyl-coa synthase/carbon monoxide dehydrogenase
Source: Moorella thermoacetica. Organism_taxid: 1525. Organism_taxid: 1525
Chains: C, D (729 residues) CATH domains: 1.10.8.190 3.40.50.2030 3.30.1650.10 3.40.970.20 3.40.1470.10
Bound ligand:   Het Group FOR corresponds to enzyme product CO
2z8y
Xenon-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs) from moorella thermoacetica
Source: Moorella thermoacetica. Organism_taxid: 1525. Organism_taxid: 1525
Chains: M, N, O, P (728 residues) CATH domains: 1.10.8.190 3.40.50.2030 3.30.1650.10 3.40.970.20 3.40.1470.10
3git
Crystal structure of a truncated acetyl-coa synthase
Source: Moorella thermoacetica. Organism_taxid: 1525. Gene: acsb2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (422 residues) CATH domains: 3.30.1650.10 3.40.970.20 3.40.1470.10
3i01
Native structure of bifunctional carbon monoxide dehydrogena coa synthase from moorella thermoacetica, water-bound c-clu
Source: Moorella thermoacetica. Clostridium thermoaceticum. Organism_taxid: 1525. Organism_taxid: 1525
Chains: M, N, O, P (728 residues) CATH domains: 1.10.8.190 3.40.50.2030 3.30.1650.10 3.40.970.20 3.40.1470.10
Bound ligand:   Het Group ACT is 66.67% similar to enzyme product CO
3i04
Cyanide-bound structure of bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase from moorella thermoaceti cyanide-bound c-cluster
Source: Moorella thermoacetica. Clostridium thermoaceticum. Organism_taxid: 1525. Organism_taxid: 1525
Chains: M, N, O, P (728 residues) CATH domains: 1.10.8.190 3.40.50.2030 3.30.1650.10 3.40.970.20 3.40.1470.10
Bound ligand:   Het Group ACT is 66.67% similar to enzyme product CO
3s2x
Structure of acetyl-coenzyme a synthase alpha subunit c-term domain
Source: Moorella thermoacetica. Organism_taxid: 1525. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (132 residues) CATH domain: 3.40.1470.10