_EC 2.3.1.16 Acetyl-CoA C-acyltransferase. 23 PDB entries  
EC 2.-.-.- Transferases. [18,993 PDB entries]
EC 2.3.-.- Acyltransferases. [1,300 PDB entries]
EC 2.3.1.- Transferring groups other than amino-acyl groups. [1,075 PDB entries]
EC 2.3.1.16 Acetyl-CoA C-acyltransferase. [23 PDB entries]    
1afw

Reaction: Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
 


Acyl-CoA
+
acetyl-CoA
=
CoA
+
3-oxoacyl-CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 3-ketoacyl-CoA thiolase. Beta-ketothiolase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 23 PDB entries in enzyme class E.C.2.3.1.16

  PDB code Protein
1afw
The 1.8 angstrom crystal structure of the dimeric peroxisomal thiolase of saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organelle: peroxisome. Cellular_location: peroxisome
Chains: A, B (390 residues) CATH domains: 3.40.47.10 3.40.47.10
1afy
The modeled structure of the thiolase/acetoactyl-coa complex, theoretical model
Source: Saccharomyces cerevisiae. Baker's yeast. Organelle: peroxisome. Cellular_location: peroxisome
Chains: A, B (390 residues)
Bound ligand:   Het Group CAA is 90.00% similar to enzyme reactant Acyl-CoA
1pxt
The 2.8 angstroms structure of peroxisomal 3-ketoacyl-coa thiolase of saccharomyces cerevisiae: a five layered a-b-a- b-a structure, constructed from two core domains of identical topology
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Chains: A, B (343 residues) CATH domains: 3.40.47.10 3.40.47.10
1wdk
Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native2)
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: C, D (390 residues) CATH domains: 3.40.47.10 3.40.47.10
Bound ligand:   Het Group ACO corresponds to enzyme reactant acetyl-CoA
1wdl
Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4)
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: C, D (390 residues) CATH domains: 3.40.47.10 3.40.47.10
Bound ligand:   Het Group ACO is 78.00% similar to enzyme reactant Acyl-CoA
1wdm
Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3)
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: C, D (390 residues) CATH domains: 3.40.47.10 3.40.47.10
Bound ligand:   Het Group ACO corresponds to enzyme reactant acetyl-CoA
2c7y
Plant enzyme
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (391 residues)
2c7z
Plant enzyme crystal form ii
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (396 residues)
2d3t
Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form v
Source: Pseudomonas fragi. Organism_taxid: 296. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: C, D (390 residues) CATH domains: 3.40.47.10 3.40.47.10
Bound ligand:   Het Group ACO corresponds to enzyme reactant acetyl-CoA
2iik
Crystal structure of human peroxisomal acetyl-coa acyl trans (acaa1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acaa1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (386 residues)
2wu9
Crystal structure of peroxisomal kat2 from arabidopsis thaliana
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Atcc: 77500. Organelle: peroxisome. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: rosettagami2(de3)
Chains: A, B (403 residues)
2wua
Structure of the peroxisomal 3-ketoacyl-coa thiolase from sunflower
Source: Helianthus annuus. Common sunflower. Organism_taxid: 4232. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (392 residues)
3goa
Crystal structure of the salmonella typhimurium fada 3- ketoacyl-coa thiolase
Source: Salmonella typhimurium. Organism_taxid: 602. Strain: lt2. Gene: fada, stm3982, stmd1.7. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (380 residues) CATH domains: 3.40.47.10 3.40.47.10
3w15
Structure of peroxisomal targeting signal 2 (pts2) of saccha cerevisiae 3-ketoacyl-coa thiolase in complex with pex7p an
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 559292. Strain: s288c. Gene: pex7. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Gene: pex21. Expressed in: escherichia coli.
Chain: C (389 residues) CATH domain: Unassigned
3zbg
Crystal structure of wild-type scp2 thiolase from leishmania mexicana at 1.85 a
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: mhom/bz/84/bel46. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (431 residues) CATH domain: Unassigned
3zbk
Crystal structure of scp2 thiolase from leishmania mexicana: the c123a mutant.
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: mhom/bz/84/bel46. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: this leishmania mexicana strain was obtained the institute for tropical medicine in antwerp.
Chains: A, B (430 residues) CATH domain: Unassigned
3zbl
Crystal structure of scp2 thiolase from leishmania mexicana: the c123s mutant.
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: mhom/bz/84/bel46. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: this leishmania mexicana strain was obtained the institute for tropical medicine in antwerp
Chains: A, B (429 residues) CATH domain: Unassigned
3zbn
Crystal structure of scp2 thiolase from leishmania mexicana. Complex of the c123a mutant with coenzyme a.
Source: Leishmania mexicana. Organism_taxid: 5665. Strain: mhom/bz/84/bel46. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: this leishmania mexicana strain was obtained the institute for tropical medicine in antwerp.
Chains: A, B, C, D (430 residues) CATH domain: Unassigned
Bound ligand:   Het Group COA corresponds to enzyme product CoA
4bi9
Crystal structure of wild-type scp2 thiolase from trypanosom
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (418 residues) CATH domain: Unassigned
4bia
Crystal structure of scp2 thiolase from trypanosoma brucei: c337a mutant.
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (418 residues) CATH domain: Unassigned
4c2j
Crystal structure of human mitochondrial 3-ketoacyl-coa thiolase in complex with coa
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (393 residues) CATH domains: 3.40.47.10 3.40.47.10
Bound ligand:   Het Group COA corresponds to enzyme product CoA
4c2k
Crystal structure of human mitochondrial 3-ketoacyl-coa thiolase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (395 residues) CATH domains: 3.40.47.10 3.40.47.10
4nzs
Crystal structure of beta-ketothiolase bktb b from ralstonia h16
Source: Ralstonia eutropha. Organism_taxid: 381666. Strain: atcc 17699 / h16 / dsm 428 / stanier 337. Gene: bktb, h16_a1445. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (393 residues) CATH domains: 3.40.47.10 3.40.47.10