_EC 2.3.1.129 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. 13 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.3.-.- Acyltransferases. [1,204 PDB entries]
EC 2.3.1.- Transferring groups other than amino-acyl groups. [994 PDB entries]
EC 2.3.1.129 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. [13 PDB entries]    
1j2z

Reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D- glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)- N-acetyl-alpha-D-glucosamine.
 


(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]
+ UDP-N-acetyl-alpha-D- glucosamine
=
[acyl-carrier-protein]
+ UDP-3-O-(3-hydroxytetradecanoyl)- N-acetyl-alpha-D-glucosamine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase. UDP-N-acetylglucosamine acyltransferase.
Comments: Involved with Ec 2.4.1.182 and Ec 2.7.1.130 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 13 PDB entries in enzyme class E.C.2.3.1.129

  PDB code Protein
1j2z
Crystal structure of udp-n-acetylglucosamine acyltransferase
Source: Helicobacter pylori. Organism_taxid: 210. Gene: lpxa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (259 residues) CATH domains: 2.160.10.10 1.20.1180.10
1lxa
Udp n-acetylglucosamine acyltransferase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: lpxa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (262 residues) CATH domains: 2.160.10.10 1.20.1180.10
2aq9
Structure of e. Coli lpxa with a bound peptide that is compe with acyl-acp
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: lpxa. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (262 residues) CATH domains: 2.160.10.10 1.20.1180.10
2jf2
Nucleotide substrate binding by udp-n-acetylglucosamine acyltransferase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (264 residues) CATH domains: 2.160.10.10 1.20.1180.10
2jf3
Nucleotide substrate binding by udp-n-acetylglucosamine acyltransferase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (262 residues) CATH domains: 2.160.10.10 1.20.1180.10
Bound ligand:   Het Group UD1 corresponds to enzyme reactant UDP-N-acetyl-D-glucosamine
2qia
Structural basis for the acyl chain selectivity and mechanism of udp-n-acetylglucosamine acyltransferase
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: lpxa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (262 residues) CATH domains: 2.160.10.10 1.20.1180.10
Bound ligand:   Het Group U20 corresponds to enzyme product UDP-3- O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
2qiv
Structural basis for the acyl chain selectivity and mechanism of udp-n-acetylglucosamine acyltransferase
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: lpxa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: X (262 residues) CATH domains: 2.160.10.10 1.20.1180.10
Bound ligand:   Het Group U21 is 92.00% similar to enzyme product UDP-3- O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
3r0s
Udp-n-acetylglucosamine acyltransferase from campylobacter j
Source: Campylobacter jejuni subsp. Jejuni. Organism_taxid: 192222. Strain: nctc 11168. Gene: cj0274, lpxa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (252 residues) CATH domains: 2.160.10.10 1.20.1180.10
3t57
Activity and crystal structure of arabidopsis udp-n-acetylgl acyltransferase
Source: Arabidopsis thaliana. Mouse-ear cress, thale-cress. Organism_taxid: 3702. Strain: var. Columbia. Gene: at4g29540, lpxa, t16l4.50. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (288 residues) CATH domains: 2.160.10.10 1.20.1180.10
4e6t
Structure of lpxa from acinetobacter baumannii at 1.8a resol (p212121 form)
Source: Acinetobacter baumannii. Organism_taxid: 470. Gene: lpxa, abtw07_2294. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 (de3)
Chains: A, B, C (264 residues) CATH domains: 2.160.10.10 1.20.1180.10
4e6u
Structure of lpxa from acinetobacter baumannii at 1.4a resol form)
Source: Acinetobacter baumannii. Organism_taxid: 470. Gene: lpxa, abtw07_2294. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 (de3)
Chain: A (258 residues) CATH domains: 2.160.10.10 1.20.1180.10
4eqy
Crystal structure of acyl-[acyl-carrier-protein]--udp-n- acetylglucosamine o-acyltransferase from burkholderia thail
Source: Burkholderia thailandensis. Organism_taxid: 271848. Strain: e264 / atcc 700388 / dsm 13276 / cip 106301. Gene: 3848943, bth_i2039, lpxa. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, E, F, G (261 residues) CATH domains: 2.160.10.10 1.20.1180.10
4j09
Crystal structure of lpxa bound to rjpxd33
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b0181, jw0176, lpxa. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: peptide synthesis
Chain: A (262 residues) CATH domains: 2.160.10.10 1.20.1180.10
Bound ligand:   Het Group TYR is 50.00% similar to enzyme reactant (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]