_EC 2.2.1.5 2-hydroxy-3-oxoadipate synthase. 12 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.2.-.- Transferring aldehyde or ketone residues. [107 PDB entries]
EC 2.2.1.- Transketolases and transaldolases. [107 PDB entries]
EC 2.2.1.5 2-hydroxy-3-oxoadipate synthase. [12 PDB entries]    
2xt6

Pathway: 2-hydroxy-3-oxoadipate synthase
Reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO(2).
 


2-oxoglutarate
+
glyoxylate
=
2-hydroxy-3-oxoadipate
+
CO(2)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating). 2-hydroxy-3-oxoadipate synthetase. Alpha-ketoglutaric-glyoxylic carboligase. Oxoglutarate: glyoxylate carboligase.
Cofactor(s): Thiamine diphosphate.
 

Thiamine diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate. Formerly Ec 4.1.3.15.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 12 PDB entries in enzyme class E.C.2.2.1.5

  PDB code Protein
2xt6
Crystal structure of mycobacterium smegmatis alpha-ketogluta decarboxylase homodimer (orthorhombic form)
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: mc2 155. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (1055 residues) CATH domains: Unassigned 3.40.50.970
2xt9
Crystal structure of mycobacterium smegmatis alpha- ketoglutarate decarboxylase in complex with gara
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: mc2 155. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (824 residues) CATH domains: 1.10.287.1150 3.40.50.970
2xta
Crystal structure of the suca domain of mycobacterium smegmatis alpha-ketoglutarate decarboxylase in complex with acetyl-coa (triclinic form)
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: mc2 155. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (826 residues) CATH domains: 1.10.287.1150 3.40.50.970
2y0p
Crystal structure of the suca domain of mycobacterium smegmatis alpha-ketoglutarate decarboxylase in complex with the enamine-thdp intermediate and acetyl-coa
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: mc2 155. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (847 residues) CATH domains: 1.10.287.1150 3.40.50.970
2yic
Crystal structure of the suca domain of mycobacterium smegma alpha-ketoglutarate decarboxylase (triclinic form)
Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc2155. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (814 residues) CATH domains: 1.10.287.1150 3.40.50.970
2yid
Crystal structure of the suca domain of mycobacterium smegmatis alpha-ketoglutarate decarboxylase in complex with the enamine-thdp intermediate
Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc2155. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (844 residues) CATH domains: 1.10.287.1150 3.40.50.970
3zhq
Crystal structure of the h747a mutant of the suca domain of mycobacterium smegmatis kgd
Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc2_155. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (811 residues) CATH domains: 1.10.287.1150 3.40.50.970
Bound ligand:   Het Group TPP corresponds to enzyme cofactor Thiamine
3zhr
Crystal structure of the h747a mutant of the suca domain of mycobacterium smegmatis kgd showing the active site lid clo
Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc2_155. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (822 residues) CATH domains: 1.10.287.1150 3.40.50.970
Bound ligands:   Het Group MPD is 50.00% similar to enzyme reactant 2-oxoglutarate
  Het Group TPP corresponds to enzyme cofactor Thiamine
3zhs
Crystal structure of the suca domain of mycobacterium smegma first post-decarboxylation intermediate from alpha-ketoglut
Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc2_155. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (817 residues) CATH domains: 1.10.287.1150 3.40.50.970
Bound ligand:   Het Group TD6 is 78.79% similar to enzyme cofactor Thiamine
3zht
Crystal structure of the suca domain of mycobacterium smegma first post-decarboxylation intermediate from 2-oxoadipate
Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc2_155. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (814 residues) CATH domains: 1.10.287.1150 3.40.50.970
Bound ligand:   Het Group TD9 is 76.47% similar to enzyme cofactor Thiamine
3zhu
Crystal structure of the suca domain of mycobacterium smegma second post-decarboxylation intermediate from 2-oxoadipate
Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc2_155. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (847 residues) CATH domains: 1.10.287.1150 3.40.50.970
Bound ligand:   Het Group TD8 is 76.47% similar to enzyme cofactor Thiamine
3zhv
Crystal structure of the suca domain of mycobacterium smegma post-decarboxylation intermediate from pyruvate (2-hydroxyethyl-thdp)
Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc2_155. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss.
Chains: A, B, C, D (820 residues) CATH domains: 1.10.287.1150 3.40.50.970
Bound ligand:   Het Group TDW is 89.66% similar to enzyme cofactor Thiamine