_EC 2.1.4.1 Glycine amidinotransferase. 11 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,710 PDB entries]
EC 2.1.4.- Amidinotransferases. [12 PDB entries]
EC 2.1.4.1 Glycine amidinotransferase. [11 PDB entries]    
1jdw

Pathway: Creatine Biosynthesis
Reaction: L-arginine + glycine = L-ornithine + guanidinoacetate.
 


L-arginine
+
glycine
=
L-ornithine
+
guanidinoacetate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-arginine:glycine amidinotransferase.
Comments: Canavanine can act instead of arginine. Formerly Ec 2.6.2.1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 11 PDB entries in enzyme class E.C.2.1.4.1

  PDB code Protein
1jdw
Crystal structure and mechanism of l-arginine: glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: kidney. Organelle: mitochondria. Cellular_location: intermembrane space of mitochondria and cytoplasm. Gene: at38h.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group BME is 50.00% similar to enzyme reactant Glycine
1jdx
Crystal structure of human l-arginine:glycine amidinotransferase in complex with l-norvaline
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl(21)de3plyss. Organ: kidney. Organelle: mitochondria. Cellular_location: cytosolic. Gene: at38h. Expressed in: escherichia coli.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group NVA is 88.00% similar to enzyme product L-ornithine
2jdw
Crystal structure and mechanism of l-arginine: glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: kidney. Organelle: mitochondria. Cellular_location: intermembrane space of mitochondria and cytoplasm. Gene: at38h.
Chain: A (360 residues) CATH domain: 3.75.10.10
2jdx
Crystal structure of human l-arginine:glycine amidinotransferase, deletionmutant atdeltam302
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl(21)de3plyss. Organ: kidney. Organelle: mitochondria. Cellular_location: cytosolic. Gene: at38h. Expressed in: escherichia coli.
Chain: A (359 residues) CATH domain: 3.75.10.10
3jdw
Crystal structure and mechanism of l-arginine: glycine amidinotransferase: a mitochondrial enzyme involved in crea biosynthesis
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: kidney. Organelle: mitochondria. Cellular_location: intermembrane space of mitochondria and cytoplasm. Gene: at38h.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group ORN corresponds to enzyme product L-ornithine
4jdw
Crystal structure and mechanism of l-arginine: glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: kidney. Organelle: mitochondria. Cellular_location: intermembrane space of mitochondria and cytoplasm. Gene: at38h.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group ARG corresponds to enzyme reactant L-arginine
5jdw
Crystal structure of human l-arginine:glycine amidinotransferase in complex with glycine
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl(21)de3plyss. Organ: kidney. Organelle: mitochondria. Cellular_location: cytosolic. Gene: at38h. Expressed in: escherichia coli.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group GLY corresponds to enzyme reactant Glycine
6jdw
Crystal structure of human l-arginine:glycine amidinotransferase in complex with gamma-amino butyric acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl(21)de3plyss. Organ: kidney. Organelle: mitochondria. Cellular_location: cytosolic. Gene: at38h. Expressed in: escherichia coli.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group ABU is 60.00% similar to enzyme product L-ornithine
7jdw
Crystal structure of human l-arginine:glycine amidinotransferase in complex with delta-amino valeric acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl(21)de3plyss. Organ: kidney. Organelle: mitochondria. Cellular_location: cytosolic. Gene: at38h. Expressed in: escherichia coli.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group DAV is 88.00% similar to enzyme product L-ornithine
8jdw
Crystal structure of human l-arginine:glycine amidinotransferase in complex with l-alanine
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl(21)de3plyss. Organ: kidney. Organelle: mitochondria. Cellular_location: cytosolic. Gene: at38h. Expressed in: escherichia coli.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group ALA is 83.00% similar to enzyme reactant Glycine
9jdw
Crystal structure of human l-arginine:glycine amidinotransferase in complex with alpha-amino butyric acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl(21)de3plyss. Organ: kidney. Organelle: mitochondria. Cellular_location: cytosolic. Gene: at38h. Expressed in: escherichia coli.
Chain: A (360 residues) CATH domain: 3.75.10.10
Bound ligand:   Het Group ABA is 77.00% similar to enzyme product L-ornithine