_EC 2.1.3.1 Methylmalonyl-CoA carboxytransferase. 11 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,711 PDB entries]
EC 2.1.3.- Carboxyl- and carbamoyltransferases. [162 PDB entries]
EC 2.1.3.1 Methylmalonyl-CoA carboxytransferase. [11 PDB entries]    
1dcz

Reaction: (S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate.
 


(S)-methylmalonyl-CoA
+
pyruvate
=
propanoyl-CoA
+
oxaloacetate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Methylmalonyl-CoA carboxyltransferase. Transcarboxylase.
Cofactor(s): Biotin; Cobalt cation; Zn(2+).
 

Biotin
Cobalt cation
Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 11 PDB entries in enzyme class E.C.2.1.3.1

  PDB code Protein
1dcz
Biotin carboxyl carrier domain of transcarboxylase (tc 1.3s)
Source: Propionibacterium freudenreichii subsp. Shermanii. Organism_taxid: 1752. Strain: subsp. Shermanii. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (77 residues) CATH domain: 2.40.50.100
1dd2
Biotin carboxyl carrier domain of transcarboxylase (tc 1.3s)
Source: Propionibacterium freudenreichii subsp. Shermanii. Organism_taxid: 1752. Strain: subsp. Shermanii. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (77 residues) CATH domain: 2.40.50.100
1o78
Biotin carboxyl carrier domain of transcarboxylase (1.3s) [10-48] deletion mutant
Source: Propionibacterium freudenreichii subsp. Shermanii. Organism_taxid: 1752. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (84 residues) CATH domain: 2.40.50.100
1on3
Transcarboxylase 12s crystal structure: hexamer assembly and substrate binding to a multienzyme core (with methylmalonyl-coenzyme a and methylmalonic acid bound)
Source: Propionibacterium freudenreichii. Organism_taxid: 1744. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (517 residues) CATH domains: 3.90.226.10 3.90.226.10
Bound ligands:   Het Group MCA corresponds to enzyme reactant (S)-methylmalonyl-CoA
  Het Group DXX is 62.00% similar to enzyme reactant pyruvate
1on9
Transcarboxylase 12s crystal structure: hexamer assembly and binding to a multienzyme core (with hydrolyzed methylmalony a bound)
Source: Propionibacterium freudenreichii. Organism_taxid: 1744. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (516 residues) CATH domains: 3.90.226.10 3.90.226.10
Bound ligands:   Het Group MCA is 51.92% similar to enzyme product propanoyl-CoA
  Het Group MPD is 54.55% similar to enzyme product oxaloacetate
1rqb
Propionibacterium shermanii transcarboxylase 5s subunit
Source: Propionibacterium freudenreichii subsp shermanii. Organism_taxid: 1752. Strain: subsp. Shermanii. Gene: 5s. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (472 residues) CATH domain: 3.20.20.70
1rqe
Propionibacterium shermanii transcarboxylase 5s subunit boun oxaloacetate
Source: Propionibacterium freudenreichii subsp shermanii. Organism_taxid: 1752. Strain: subsp. Shermanii. Gene: 5s. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (472 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group OAA corresponds to enzyme product oxaloacetate
1rqh
Propionibacterium shermanii transcarboxylase 5s subunit boun pyruvic acid
Source: Propionibacterium freudenreichii subsp shermanii. Organism_taxid: 1752. Strain: subsp. Shermanii. Gene: 5s. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (472 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group PYR corresponds to enzyme reactant pyruvate
1rr2
Propionibacterium shermanii transcarboxylase 5s subunit boun ketobutyric acid
Source: Propionibacterium freudenreichii subsp shermanii. Organism_taxid: 1752. Gene: 5s. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (473 residues) CATH domain: 3.20.20.70
Bound ligand:   Het Group 2KT is 85.71% similar to enzyme reactant pyruvate
1s3h
Propionibacterium shermanii transcarboxylase 5s subunit a59t
Source: Propionibacterium freudenreichii subsp shermanii. Organism_taxid: 1752. Strain: subsp. Shermanii. Gene: 5s. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (472 residues) CATH domain: 3.20.20.70
1u5j
Propionibacterium shermanii transcarboxylase 5s subunit, met186ile
Source: Propionibacterium freudenreichii subsp. Shermanii. Organism_taxid: 1752. Strain: subsp. Shermanii. Gene: 5s. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (471 residues) CATH domain: 3.20.20.70