_EC 2.1.2.3 Phosphoribosylaminoimidazolecarboxamide formyltransferase. 16 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,710 PDB entries]
EC 2.1.2.- Hydroxymethyl-, formyl- and related transferases. [156 PDB entries]
EC 2.1.2.3 Phosphoribosylaminoimidazolecarboxamide formyltransferase. [16 PDB entries]    
1g8m

Pathway: Purine Biosynthesis (late stages)
Reaction: 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
 


10-formyltetrahydrofolate
+
5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide
=
tetrahydrofolate
+
5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4- imidazolecarboxamide formyltransferase. 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase. 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase. 5-amino-4-imidazolecarboxamide ribonucleotide transformylase. 5-amino-4-imidazolecarboxamide ribotide transformylase. Aicar formyltransferase. Aicar transformylase. Aminoimidazolecarboxamide ribonucleotide transformylase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 16 PDB entries in enzyme class E.C.2.1.2.3

  PDB code Protein
1g8m
Crystal structure of avian atic, a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis at 1.75 ang. Resolution
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: purh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (590 residues) CATH domains: 1.10.287.440 3.40.140.20 3.40.140.20 3.40.50.1380
Bound ligand:   Het Group G is 92.00% similar to enzyme product 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide
1m9n
Crystal structure of the homodimeric bifunctional transformy cyclohydrolase enzyme avian atic in complex with aicar and 1.93 angstroms.
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: purh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (590 residues) CATH domains: 1.10.287.440 3.40.140.20 3.40.140.20 3.40.50.1380
Bound ligands:   Het Group AMZ corresponds to enzyme reactant 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
  Het Group XMP corresponds to enzyme product 5-formamido-1-(5-phospho-D-
1oz0
Crystal structure of the homodimeric bifunctional transformylase and cyclohydrolase enzyme avian atic in complex with a multisubstrate adduct inhibitor beta-dadf.
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: atic or purh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (590 residues) CATH domains: 1.10.287.440 3.40.140.20 3.40.140.20 3.40.50.1380
Bound ligand:   Het Group MS1 is 56.00% similar to enzyme reactant 10-formyltetrahydrofolate
1p4r
Crystal structure of human atic in complex with folate- based inhibitor bw1540u88ud
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: atic cdna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (589 residues) CATH domains: 1.10.287.440 3.40.140.20 3.40.140.20 3.40.50.1380
Bound ligands:   Het Group AMZ corresponds to enzyme reactant 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide
  Het Group 354 is 40.00% similar to enzyme product 5,6,7,8-tetrahydrofolate
  Het Group XMP corresponds to enzyme product 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide
1pkx
Crystal structure of human atic in complex with xmp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: atic. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (588 residues) CATH domains: 1.10.287.440 3.40.140.20 3.40.140.20 3.40.50.1380
Bound ligand:   Het Group XMP corresponds to enzyme product 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide
1pl0
Crystal structure of human atic in complex with folate- based inhibitor, bw2315u89uc
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: atic. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (589 residues) CATH domains: 1.10.287.440 3.40.140.20 3.40.140.20 3.40.50.1380
Bound ligand:   Het Group XMP corresponds to enzyme product 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide
1thz
Crystal structure of avian aicar transformylase in complex with a novel inhibitor identified by virtual ligand screening
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: atic, purh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (590 residues) CATH domains: 1.10.287.440 3.40.140.20 3.40.140.20 3.40.50.1380
1zcz
Crystal structure of phosphoribosylaminoimidazolecarboxamide formyltransferase / imp cyclohydrolase (tm1249) from thermo maritima at 1.88 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: purh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (452 residues) CATH domain: 3.40.50.1380
2b0w
Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
Source: Gallus gallus. Chicken. Gene: atic, purh. Expressed in: escherichia coli.
Chains: ( residues)
2b1g
Crystal structures of transition state analogue inhibitors o monophosphate cyclohydrolase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: atic, purh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (590 residues) CATH domains: 3.40.50.1380 3.40.140.20 Unassigned 1.10.287.440
Bound ligand:   Het Group 13A is 72.00% similar to enzyme reactant 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
2b1i
Crystal structures of transition state analogue inhibitors o monophosphate cyclohydrolase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: atic, purh. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (590 residues) CATH domains: 3.40.50.1380 3.40.140.20 Unassigned 1.10.287.440
Bound ligand:   Het Group 93A is 88.00% similar to enzyme reactant 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
2iu0
Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (590 residues) CATH domains: 3.40.50.1380 3.40.140.20 Unassigned 1.10.287.440
2iu3
Crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21(de3).
Chains: A, B (590 residues) CATH domains: 3.40.50.1380 3.40.140.20 Unassigned 1.10.287.440
3zzm
Crystal structure of mycobacterium tuberculosis purh with a bound nucleotide cfair, at 2.2 a resolution.
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (520 residues) CATH domain: 3.40.50.1380
Bound ligand:   Het Group JLN is 92.00% similar to enzyme product 5-formamido-1-(5-phospho-D-
4a1o
Crystal structure of mycobacterium tuberculosis purh complex aicar and a novel nucleotide cfair, at 2.48 a resolution.
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Atcc: 25618. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (516 residues) CATH domain: 3.40.50.1380
Bound ligands:   Het Group AMZ corresponds to enzyme reactant 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
  Het Group JLN is 92.00% similar to enzyme product 5-formamido-1-(5-phospho-D-
4ehi
An x-ray crystal structure of a putative bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/i cyclohydrolase
Source: Campylobacter jejuni subsp. Jejuni. Organism_taxid: 192222. Strain: nctc 11168. Gene: cj0953c, purh. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (485 residues) CATH domain: 3.40.50.1380