_EC 2.1.2.2 Phosphoribosylglycinamide formyltransferase. 33 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,710 PDB entries]
EC 2.1.2.- Hydroxymethyl-, formyl- and related transferases. [156 PDB entries]
EC 2.1.2.2 Phosphoribosylglycinamide formyltransferase. [33 PDB entries]    
1c2t

Pathway: Purine Biosynthesis (early stages)
Reaction: 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
 


10-formyltetrahydrofolate
+
N(1)-(5-phospho-D-ribosyl)glycinamide
=
tetrahydrofolate
+
N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 2-amino-N-ribosylacetamide 5'-phosphate transformylase. 5'-phosphoribosylglycinamide transformylase. 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase. Gar formyltransferase. Gar TFase. Gar transformylase. Gart. Glycinamide ribonucleotide transformylase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 33 PDB entries in enzyme class E.C.2.1.2.2

  PDB code Protein
1c2t
New insights into inhibitor design from the crystal structur studies of e. Coli gar transformylase in complex with beta- 10-formyl-5,8,10-trideazafolic acid.
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (209 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group GAR corresponds to enzyme reactant N(1)-(5-phospho-D-ribosyl)glycinamide
1c3e
New insights into inhibitor design from the crystal structure and nmr studies of e. Coli gar transformylate in complex with beta-gar and 10-formyl-5,8,10-trideazafolic acid.
Source: Escherichia coli. Organism_taxid: 562. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (209 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group GAR corresponds to enzyme reactant N(1)-(5-phospho-D-ribosyl)glycinamide
1cdd
Structures of apo and complexed escherichia coli glycinamide ribonucleotide transformylase
Source: Escherichia coli. Organism_taxid: 562.
Chains: A, B (189 residues) CATH domain: 3.40.50.170
1cde
Structures of apo and complexed escherichia coli glycinamide ribonucleotide transformylase
Source: Escherichia coli. Organism_taxid: 562.
Chains: A, B, C, D (209 residues) CATH domain: 3.40.50.170
Bound ligands:   Het Group GAR corresponds to enzyme reactant N(1)-(5-phospho-D-ribosyl)glycinamide
  Het Group DZF is 93.00% similar to enzyme product 5,6,7,8-tetrahydrofolate
1gar
Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 angstroms resolution
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (205 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group U89 is 41.00% similar to enzyme reactant 10-formyltetrahydrofolate
1grc
Crystal structure of glycinamide ribonucleotide transformylase from escherichia coli at 3.0 angstroms resolution: a target enzyme for chemotherapy
Source: Escherichia coli. Organism_taxid: 562.
Chains: A, B (194 residues) CATH domain: 3.40.50.170
1jkx
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of gar transformylase
Source: Escherichia coli. Organism_taxid: 562. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (209 residues) CATH domain: 3.40.50.170
1mej
Human glycinamide ribonucleotide transformylase domain at ph
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A, C (201 residues) CATH domain: 3.40.50.170
1men
Complex structure of human gar tfase and substrate beta-gar
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (201 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group GAR corresponds to enzyme reactant N(1)-(5-phospho-D-ribosyl)glycinamide
1meo
Human glycinamide ribonucleotide transformylase at ph 4.2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (202 residues) CATH domain: 3.40.50.170
1nfe
Phosphoribosylglycinamide formyltransferase 2 from e.Coli
Source: Escherichia coli. Bacteria
Chain: A (391 residues)
1njs
Human gar tfase in complex with hydrolyzed form of 10- trifluoroacetyl-5,10-dideaza-acyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (200 residues) CATH domain: 3.40.50.170
1rbm
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (200 residues) CATH domain: 3.40.50.170
1rbq
Human gar tfase complex structure with 10-(trifluoroacetyl)- 5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (200 residues) CATH domain: 3.40.50.170
1rby
Human gar tfase complex structure with 10-(trifluoroacetyl)- 5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid and substrate beta-gar
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (200 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group GAR corresponds to enzyme reactant N(1)-(5-phospho-D-ribosyl)glycinamide
1rbz
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (200 residues) CATH domain: 3.40.50.170
1rc0
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (200 residues) CATH domain: 3.40.50.170
1rc1
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: purn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (200 residues) CATH domain: 3.40.50.170
1zlx
The apo structure of human glycinamide ribonucleotide transf
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, prgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (200 residues) CATH domain: 3.40.50.170
1zly
The structure of human glycinamide ribonucleotide transformylase in complex with alpha,beta-n- (hydroxyacetyl)-d-ribofuranosylamine and 10-formyl-5,8, dideazafolate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, prgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (200 residues) CATH domain: 3.40.50.170
Bound ligands:   Het Group GRF is 77.00% similar to enzyme reactant N(1)-(5-phospho-D-ribosyl)glycinamide
  Het Group DQB is 45.00% similar to enzyme product 5,6,7,8-tetrahydrofolate
2gar
A ph-dependent stablization of an active site loop observed from low and high ph crystal structures of mutant monomeric glycinamide ribonucleotide transformylase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (188 residues) CATH domain: 3.40.50.170
2qk4
Human glycinamide ribonucleotide synthetase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, pgft, prgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (420 residues) CATH domains: 3.40.50.20 3.30.1490.20 3.30.470.20 3.90.600.10
Bound ligand:   Het Group ATP is 54.55% similar to enzyme product N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide
2v9y
Human aminoimidazole ribonucleotide synthetase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (314 residues) CATH domains: 3.30.1330.10 3.90.650.10
3av3
Crystal structure of glycinamide ribonucleotide transformyla geobacillus kaustophilus
Source: Geobacillus kaustophilus. Organism_taxid: 235909. Strain: hta426. Gene: gk0266. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (188 residues) CATH domain: 3.40.50.170
3da8
Crystal structure of purn from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: purn, mt0983, rv0956. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (213 residues) CATH domain: 3.40.50.170
3dcj
Crystal structure of glycinamide formyltransferase (purn) from mycobacterium tuberculosis in complex with 5-methyl-5, 6,7,8-tetrahydrofolic acid derivative
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: purn, mt0983, rv0956. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (206 residues) CATH domain: 3.40.50.170
Bound ligand:   Het Group THH is 96.00% similar to enzyme product 5,6,7,8-tetrahydrofolate
3gar
A ph-dependent stablization of an active site loop observed from low and high ph crystal structures of mutant monomeric glycinamide ribonucleotide transformylase
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (209 residues) CATH domain: 3.40.50.170
3kcq
Crystal structure of phosphoribosylglycinamide formyltransfe anaplasma phagocytophilum
Source: Anaplasma phagocytophilum. Organism_taxid: 212042. Strain: hz. Gene: purn, aph_0230. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (207 residues) CATH domain: 3.40.50.170
3tqr
Structure of the phosphoribosylglycinamide formyltransferase complex with ches from coxiella burnetii
Source: Coxiella burnetii. Organism_taxid: 777. Gene: purn, cbu_1737. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (211 residues) CATH domain: 3.40.50.170
4ds3
Crystal structure of phosphoribosylglycinamide formyltransfe brucella melitensis
Source: Brucella melitensis bv. 1. Organism_taxid: 224914. Strain: 16m / atcc 23456 / nctc 10094. Gene: bawg_0970, bmei1241, phosphoribosylglycinamide formyltransferase. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (192 residues) CATH domain: 3.40.50.170
4ew1
High resolution structure of human glycinamide ribonucleotid transformylase in apo form.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, pgft, prgs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (205 residues) CATH domain: 3.40.50.170
4ew2
The structure of human glycinamide ribonucleotide transformy complex with 10s-methylthio-ddathf.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, pgft, prgs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (205 residues) CATH domain: 3.40.50.170
4ew3
The structure of human glycinamide ribonucleotide transformy complex with 10r-methylthio-ddathf.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gart, pgft, prgs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (205 residues) CATH domain: 3.40.50.170