_EC 2.1.1.77 Protein-L-isoaspartate(D-aspartate) O-methyltransferase. 12 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,710 PDB entries]
EC 2.1.1.- Methyltransferases. [1,380 PDB entries]
EC 2.1.1.77 Protein-L-isoaspartate(D-aspartate) O-methyltransferase. [12 PDB entries]    
1dl5

Reaction: S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L- homocysteine + protein L-isoaspartate alpha-methyl ester.
 


S-adenosyl-L-methionine
+
protein L-isoaspartate
=
S-adenosyl-L- homocysteine
+
protein L-isoaspartate alpha-methyl ester
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): L-isoaspartyl protein carboxyl methyltransferase. Protein beta-aspartate O-methyltransferase. Protein D-aspartate methyltransferase. Protein L-isoaspartyl methyltransferase.
Comments: D-aspartate (but not L-aspartate) residues in proteins can also act as acceptors. Formerly Ec 2.1.1.24.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 12 PDB entries in enzyme class E.C.2.1.1.77

  PDB code Protein
1dl5
Protein-l-isoaspartate o-methyltransferase
Source: Thermotoga maritima. Organism_taxid: 2336. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (317 residues) CATH domains: 3.40.50.150 3.55.20.10
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1i1n
Human protein l-isoaspartate o-methyltransferase with s- adenosyl homocysteine
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: fetal brain. Gene: pimt_human. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (224 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1jg1
Crystal structure of l-isoaspartyl (d-aspartyl) o- methyltransferase with s-adenosyl-l-homocysteine
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (215 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1jg2
Crystal structure of l-isoaspartyl (d-aspartyl) o- methyltransferase with adenosine
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (215 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group ADN is 66.00% similar to enzyme product S-adenosylhomocysteine
1jg3
Crystal structure of l-isoaspartyl (d-aspartyl) o-methyltran with adenosine & vyp(isp)ha substrate
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (215 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group IAS is 61.54% similar to enzyme reactant protein
  Het Group ADN is 66.67% similar to enzyme product S-adenosylhomocysteine
1jg4
Crystal structure of l-isoaspartyl (d-aspartyl) o- methyltransferase with s-adenosylmethionine
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (215 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
1kr5
Crystal structure of human l-isoaspartyl methyltransferase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (218 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1r18
Drosophila protein isoaspartyl methyltransferase with s-aden homocysteine
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: pcmt. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (223 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1vbf
Crystal structure of protein l-isoaspartate o-methyltransfer homologue from sulfolobus tokodaii
Source: Sulfolobus tokodaii. Organism_taxid: 111955. Gene: st1123. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (224 residues) CATH domain: 3.40.50.150
2yxe
Crystal structure of l-isoaspartyl protein carboxyl methyltr
Source: Methanocaldococcus jannaschii. Organism_taxid: 243232. Strain: dsm 2661. Gene: pcm. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (214 residues) CATH domain: 3.40.50.150
3lbf
Crystal structure of protein l-isoaspartyl methyltransferase escherichia coli
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (207 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4o29
Protein-l-isoaspartate o-methyltransferase from pyrobaculum in complex with s-adenosyl-l-homocysteine
Source: Pyrobaculum aerophilum. Organism_taxid: 178306. Strain: im2. Gene: pae0701, pcm, pimt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (207 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine