_EC 2.1.1.70 8-hydroxyfuranocoumarin 8-O-methyltransferase. 0 PDB entries  
EC 2.-.-.- Transferases. [15,100 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,417 PDB entries]
EC 2.1.1.- Methyltransferases. [1,143 PDB entries]
EC 2.1.1.70 8-hydroxyfuranocoumarin 8-O-methyltransferase. [-]    

Reaction: (1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L- homocysteine + an 8-methoxyfurocoumarin. (2) S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin.
 


S-adenosyl-L-methionine
+ 8-hydroxyfurocoumarin
=
S-adenosyl-L- homocysteine
+ 8-methoxyfurocoumarin

S-adenosyl-L-methionine
+
xanthotoxol
=
S-adenosyl-L-homocysteine
+
xanthotoxin
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Furanocoumarin 8-methyltransferase. Furanocoumarin 8-O-methyl-transferase. Xanthotoxol 8-O-methyltransferase. Xmt.
Comments: Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols. See also Ec 2.1.1.69. Formerly Ec 2.1.1.93.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.2.1.1.70