_EC 2.1.1.6 Catechol O-methyltransferase. 29 PDB entries  
EC 2.-.-.- Transferases. [16,702 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,589 PDB entries]
EC 2.1.1.- Methyltransferases. [1,247 PDB entries]
EC 2.1.1.6 Catechol O-methyltransferase. [29 PDB entries]    
1h1d

Reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
 


S-adenosyl-L-methionine
+
catechol
=
S-adenosyl-L-homocysteine
+
guaiacol
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 29 PDB entries in enzyme class E.C.2.1.1.6

  PDB code Protein
1h1d
Catechol o-methyltransferase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold.
Chain: A (214 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
1jr4
Catechol o-methyltransferase bisubstrate-inhibitor complex
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (212 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group CL4 is 42.00% similar to enzyme product S-adenosyl-L-methionine
1vid
Catechol o-methyltransferase
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group DNC is 57.00% similar to enzyme reactant
2cl5
Catechol-o-methyltransferase in complex with an inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (215 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group BIE is 42.00% similar to enzyme reactant
2zlb
Crystal structure of apo form of rat catechol-o- methyltransferase
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (212 residues) CATH domain: 3.40.50.150
2zth
Crystal structure of holo form of rat catechol-o- methyltransferase
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (206 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
2zvj
Crystal structures of rat catechol-o-methyltransferase complexed with coumarine-based inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (212 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group KOM is 47.00% similar to enzyme product
3a7d
Crystal structures of rat catechol-o-methyltransferase compl new bi-substrate type inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (214 residues) CATH domain: 3.40.50.150
3a7e
Crystal structure of human comt complexed with sam and 3,5- dinitrocatechol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (212 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group DNC is 57.00% similar to enzyme reactant
3bwm
Crystal structure of human catechol o-methyltransferase with bound sam and dnc
Source: Homo sapiens. Human. Gene: comt. Expressed in: escherichia coli.
Chain: A (214 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group DNC is 57.00% similar to enzyme reactant
3bwy
Crystal structure of human 108m catechol o- methyltransferase bound with s-adenosylmethionine and inhibitor dinitrocatechol
Source: Homo sapiens. Human. Gene: comt. Expressed in: escherichia coli.
Chain: A (214 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group DNC is 57.00% similar to enzyme reactant
3hvh
Rat catechol o-methyltransferase in complex with a catechol- methyladenine-containing bisubstrate inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
3hvi
Rat catechol o-methyltransferase in complex with a catechol- ethyladenine-containing bisubstrate inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group D1D is 60.00% similar to enzyme reactant S-adenosyl-L-methionine
3hvj
Rat catechol o-methyltransferase in complex with a catechol- propyladenine-containing bisubstrate inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (213 residues) CATH domain: 3.40.50.150
3hvk
Rat catechol o-methyltransferase in complex with a catechol- purine-containing bisubstrate inhibitor - humanized form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group NHE is 40.00% similar to enzyme reactant S-adenosyl-L-methionine
3nw9
Rat comt in complex with a methylpurin-containing bisubstrat inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group NHE is 40.00% similar to enzyme reactant S-adenosyl-L-methionine
3nwb
Rat comt in complex with a fluorinated desoxyribose-containi bisubstrate inhibitor avoids hydroxyl group
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group NHE is 40.00% similar to enzyme reactant S-adenosyl-L-methionine
3nwe
Rat comt in complex with a methylated desoxyribose bisubstra containing inhibitor avoids hydroxyl group
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group NHE is 40.00% similar to enzyme reactant S-adenosyl-L-methionine
3oe4
Rat catechol o-methyltransferase in complex with a catechol- purine-containing bisubstrate inhibitor - humanized form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group 610 is 40.48% similar to enzyme product S-adenosyl-L-methionine
3oe5
Rat catechol o-methyltransferase in complex with a catechol- pyridylsulfanyl-containing inhibitor - humanized form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
3ozr
Rat catechol o-methyltransferase in complex with a catechol- bisubstrate inhibitor, no substituent in the adenine site - form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
3ozs
Rat catechol o-methyltransferase in complex with a catechol- trifluoromethyl-imidazolyl-containing inhibitor - humanized
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
3ozt
Rat catechol o-methyltransferase in complex with a catechol- oxo-pyridinyl-containing inhibitor - humanized form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
3p9c
Crystal structure of perennial ryegrass lpomt1 bound to sah
Source: Lolium perenne. Perennial ryegrass. Organism_taxid: 4522. Gene: lpomt1, omt1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (352 residues) CATH domains: 1.10.10.10 3.40.50.150
Bound ligands:   Het Group DTV is 60.00% similar to enzyme reactant S-adenosyl-L-methionine
  Het Group SAH corresponds to enzyme product
3p9i
Crystal structure of perennial ryegrass lpomt1 complexed wit adenosyl-l-homocysteine and sinapaldehyde
Source: Lolium perenne. Perennial ryegrass. Organism_taxid: 4522. Gene: lpomt1, omt1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (357 residues) CATH domains: 1.10.10.10 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosyl-L-methionine
  Het Group SNY is 60.00% similar to enzyme product
3p9k
Crystal structure of perennial ryegrass lpomt1 complexed wit adenosyl-l-homocysteine and coniferaldehyde
Source: Lolium perenne. Perennial ryegrass. Organism_taxid: 4522. Gene: lpomt1, omt1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (357 residues) CATH domains: 1.10.10.10 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosyl-L-methionine
  Het Group CIY is 69.23% similar to enzyme product
3r6t
Rat catechol o-methyltransferase in complex with the bisubst inhibitor 4'-fluoro-4,5-dihydroxy-biphenyl-3-carboxylic aci [(2s,4r,5r)-4-hydroxy-5-(6-methyl-purin-9-yl)-tetrahydro-fu allyl}-amide
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group DTD is 60.00% similar to enzyme reactant S-adenosyl-L-methionine
3s68
Rat comt in complex with sam and tolcapone at 1.85a, p3221,
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Tissue: liver. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (213 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group TCW is 40.00% similar to enzyme reactant
3u81
Crystal structure of a sah-bound semi-holo form of rat catec methyltransferase
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (218 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosyl-L-methionine