_EC 2.1.1.57 Methyltransferase cap1. 122 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,710 PDB entries]
EC 2.1.1.- Methyltransferases. [1,380 PDB entries]
EC 2.1.1.57 Methyltransferase cap1. [122 PDB entries]    
1av6

Reaction: S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)- (purine-ribonucleotide)-(mRNA) = S-adenosyl-L-homocysteine + a 5'-(N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)- (mRNA).
 


S-adenosyl-L-methionine
+ 5'-(N(7)-methyl 5'-triphosphoguanosine)- (purine-ribonucleotide)-(mRNA)
=
S-adenosyl-L-homocysteine
+ 5'-(N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)- (mRNA)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Cap1-MTase. mRNA (nucleoside-2'-O)-methyltransferase.
Comments: This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine. Formerly Ec 2.1.1.58.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 122 PDB entries in enzyme class E.C.2.1.1.57

  PDB code Protein
1av6
Vaccinia methyltransferase vp39 complexed with m7g capped rn and s-adenosylhomocysteine
Source: Vaccinia virus wr. Vacv. Organism_taxid: 10254. Strain: western reserve. Gene: paps, vacwr095, f9. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (289 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group MGT is 47.00% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1b42
Vaccinia methyltransferase vp39 complexed with m1ade and s- adenosylhomocysteine
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1bky
Vaccinia methyltransferase vp39 complexed with m1cyt and s- adenosylhomocysteine
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1eam
Vaccinia methyltransferase vp39 mutant (ec: 2.7.7.19)
Source: Vaccinia virus. Organism_taxid: 10245. Strain: bl21 (de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (285 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1eqa
Vaccinia methyltransferase vp39 mutant e233q complexed with m7g and s-adenosylhomocysteine
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1jsz
Crystal structure analysis of n7,9-dimethylguanine-vp39 complex
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1jte
Crystal structure analysis of vp39 f180w mutant
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1jtf
Crystal structure analysis of vp39-f180w mutant and m7gpppg complex
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group M7G is 41.00% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1l9k
Dengue methyltransferase
Source: Dengue virus. Organism_taxid: 11060. Strain: 2. Gene: ns5 new guinea c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1n6g
The structure of immature dengue-2 prm particles
Source: Dengue virus 2 puerto rico/pr159- s1/1969. Organism_taxid: 11066. Strain: pr159/s1
Chains: A, B, C (395 residues)
1na4
The structure of immature yellow fever virus particle
Source: Yellow fever virus. Organism_taxid: 11089
Chains: A, B, C ( residues)
1oan
Crystal structure of the dengue 2 virus envelope protein
Source: Dengue virus type 2. Organism_taxid: 11060. Strain: strain pr159/s1. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: schneider 2.
Chains: A, B (394 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10 2.60.40.350
1ok8
Crystal structure of the dengue 2 virus envelope glycoprotein in the postfusion conformation
Source: Dengue virus type 2. Organism_taxid: 11060. Strain: pr159/s1. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: schneider 2.
Chain: A (380 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10 2.60.40.350
1oke
Crystal structure of the dengue 2 virus envelope protein in complex with n-octyl-beta-d-glucoside
Source: Dengue virus type 2. Organism_taxid: 11060. Strain: pr159/s1. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: schneider 2.
Chains: A, B (394 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10 2.60.40.350
1p39
Dc26 mutant of vaccinia virus protein vp39 in complex with s adenosylhomocysteine and m7g(5')pppg
Source: Vaccinia virus. Organism_taxid: 10254. Strain: wr. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group MGT is 47.06% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1p58
Complex organization of dengue virus membrane proteins as re 9.5 angstrom cryo-em reconstruction
Source: Dengue virus 2 puerto rico/pr159-s1/19 organism_taxid: 11066. Strain: pr159/s1. Strain: pr159/s1
Chains: A, B, C (490 residues)
1r6a
Structure of the dengue virus 2'o methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
Source: Dengue virus 2 puerto rico/pr159- s1/1969. Organism_taxid: 11066. Strain: pr159-s1. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (262 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1r6r
Solution structure of dengue virus capsid protein reveals a new fold
Source: Dengue virus 2 puerto rico/pr159- s1/1969. Organism_taxid: 11066. Strain: pr-159-s1. Gene: capsid gene. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (80 residues) CATH domain: Unassigned
1sfk
Core (c) protein from west nile virus, subtype kunjin
Source: Kunjin virus. Organism_taxid: 11078. Strain: mrm61c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (73 residues)
1svb
Envelope glycoprotein from tick-borne encephalitis virus
Source: Tick-borne encephalitis virus. Organism_taxid: 11084
Chain: A (395 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10 2.60.40.350
1thd
Complex organization of dengue virus e protein as revealed by 9.5 angstrom cryo-em reconstruction
Source: Dengue virus 2 puerto rico/pr159- s1/1969. Organism_taxid: 11066. Strain: pr159-s1
Chains: A, B, C (390 residues)
1uzg
Crystal structure of the dengue type 3 virus envelope protein
Source: Dengue virus type 3. Organism_taxid: 11069. Cell_line: drosophila schneider 2. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: schneider 2.
Chains: A, B (392 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10 2.60.40.350
1v39
Dc26 mutant of vaccinia virus protein vp39 in complex with s adenosylhomocysteine and m7g(5')pppg
Source: Vaccinia virus. Organism_taxid: 10254. Strain: wr. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group M7G is 42.65% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1vp3
Vaccinia virus protein vp39 in complex with s-adenosylhomocy
Source: Vaccinia virus. Organism_taxid: 10254. Strain: wr. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1vp9
Dc26 mutant of vaccinia virus protein vp39 in complex with s adenosylhomocysteine
Source: Vaccinia virus. Organism_taxid: 10254. Strain: wr. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1vpt
As11 variant of vaccinia virus protein vp39 in complex with adenosyl-l-methionine
Source: Vaccinia virus. Organism_taxid: 10254. Strain: wr. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
1yks
Crystal structure of yellow fever virus ns3 helicase
Source: Yellow fever virus. Organism_taxid: 11089. Strain: strain pasteur 17d-204. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (431 residues) CATH domains: Unassigned 3.40.50.300
1ymf
Crystal structure of yellow fever virus ns3 helicase complexed with adp
Source: Yellow fever virus. Organism_taxid: 11089. Strain: strain pasteur 17d-204. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (431 residues) CATH domains: Unassigned 3.40.50.300
Bound ligand:   Het Group ADP is 51.00% similar to enzyme product S-adenosylhomocysteine
1z66
Nmr solution structure of domain iii of e-protein of tick- borne langat flavivirus (no rdc restraints)
Source: Langat virus. Organism_taxid: 11085. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (93 residues) CATH domain: 2.60.40.350
2fp7
West nile virus ns2b/ns3protease in complex with bz-nle-lys-
Source: West nile virus. Organism_taxid: 11082. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B (40 residues) CATH domain: Unassigned
2ga9
Crystal structure of the heterodimeric vaccinia virus polyad polymerase with bound atp-gamma-s
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (288 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group AGS is 46.15% similar to enzyme product S-adenosylhomocysteine
2gaf
Crystal structure of the vaccinia polyadenylate polymerase heterodimer (apo form)
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (286 residues) CATH domain: 3.40.50.150
2gg1
Nmr solution structure of domain iii of the e-protein of tick-borne langat flavivirus (includes rdc restraints)
Source: Langat virus. Organism_taxid: 11085. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (93 residues) CATH domain: 2.60.40.350
2ggv
Crystal structure of the west nile virus ns2b-ns3 protease, his51ala mutant
Source: West nile virus. Organism_taxid: 11082. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (44 residues) CATH domain: Unassigned
2h0p
Nmr structure of the dengue-4 virus envelope protein domain iii
Source: Dengue virus 4. Organism_taxid: 11070. Strain: 4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (112 residues) CATH domain: 2.60.40.350
2hcn
Crystal structure of RNA dependent RNA polymerase domain fro nile virus
Source: Kunjin virus. Organism_taxid: 11077. Strain: kunjin. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (486 residues) CATH domains: Unassigned Unassigned Unassigned
2hcs
Crystal structure of RNA dependant RNA polymerase domain of virus
Source: Kunjin virus. Organism_taxid: 11077. Strain: kunjin. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (487 residues) CATH domains: Unassigned Unassigned Unassigned
2hfz
Crystal structure of RNA dependent RNA polymerase domain from west nile virus
Source: Kunjin virus. Organism_taxid: 11077. Strain: kunjin. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (608 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned
2ijo
Crystal structure of the west nile virus ns2b-ns3 protease complexed with bovine pancreatic trypsin inhibitor
Source: West nile virus. Organism_taxid: 11082. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913
Chains: A, B (41 residues) CATH domain: Unassigned
2jlq
Dengue virus 4 ns3 helicase structure, apo enzyme.
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (451 residues) CATH domains: Unassigned 3.40.50.300
2jlr
Dengue virus 4 ns3 helicase in complex with amppnp
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (439 residues) CATH domains: Unassigned 3.40.50.300
Bound ligand:   Het Group ANP is 46.15% similar to enzyme product S-adenosylhomocysteine
2jls
Dengue virus 4 ns3 helicase in complex with adp
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (443 residues) CATH domains: Unassigned 3.40.50.300
Bound ligand:   Het Group ADP is 51.43% similar to enzyme product S-adenosylhomocysteine
2jlu
Dengue virus 4 ns3 helicase in complex with ssrna
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (451 residues) CATH domains: Unassigned 3.40.50.300
2jlv
Dengue virus 4 ns3 helicase in complex with ssrna and amppnp
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (451 residues) CATH domains: Unassigned 3.40.50.300
Bound ligand:   Het Group ANP is 46.15% similar to enzyme product S-adenosylhomocysteine
2jlw
Dengue virus 4 ns3 helicase in complex with ssrna2
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (450 residues) CATH domains: Unassigned 3.40.50.300
2jlx
Dengue virus 4 ns3 helicase in complex with ssrna and adp- vanadate
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (451 residues) CATH domains: Unassigned 3.40.50.300
Bound ligand:   Het Group ADP is 51.43% similar to enzyme product S-adenosylhomocysteine
2jly
Dengue virus 4 ns3 helicase in complex with ssrna and adp- phosphate
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (451 residues) CATH domains: Unassigned 3.40.50.300
Bound ligand:   Het Group ADP is 51.43% similar to enzyme product S-adenosylhomocysteine
2jlz
Dengue virus 4 ns3 helicase in complex with ssrna and adp
Source: Dengue virus 4. Organism_taxid: 408688. Strain: thailand/0348/1991. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (451 residues) CATH domains: Unassigned 3.40.50.300
Bound ligand:   Het Group ADP is 51.43% similar to enzyme product S-adenosylhomocysteine
2jqm
Yellow fever envelope protein domain iii nmr structure (s288-k398)
Source: Yellow fever virus. Strain: asibi. Expressed in: escherichia coli. Other_details: the n-terminal his tag of this vector was removed
Chain: A (112 residues) CATH domain: 2.60.40.350
2jv6
Yf ed3 protein nmr structure
Source: Yellow fever virus. Yfv. Organism_taxid: 11089. Strain: asibi 17d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (112 residues) CATH domain: 2.60.40.350
2m9p
Nmr structure of an inhibitor bound dengue ns3 protease
Source: Dengue virus 2. Organism_taxid: 413041. Strain: thailand/0168/1979. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (240 residues)
2m9q
Nmr structure of an inhibitor bound dengue ns3 protease
Source: Dengue virus 2. Organism_taxid: 413041. Strain: thailand/0168/1979. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (240 residues)
2p1d
Crystal structure of dengue methyltransferase in complex wit s-adenosyl-l-homocysteine
Source: Dengue virus 2. Organism_taxid: 11060. Strain: type 2 new guinea. Gene: nsp5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (259 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2p5p
Crystal structure analysis of the west nile virus envelope (e) protein domain iii
Source: West nile virus. Organism_taxid: 11082. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (101 residues) CATH domain: 2.60.40.350
2px2
Crystal structure of the murray valley encephalitis virus ns5 2'-o methyltransferase domain in complex with sah (monoclinic form 1)
Source: Murray valley encephalitis virus (strain mve-1-51). Organism_taxid: 301478. Strain: mve-1-51, mvev. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (255 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2px4
Crystal structure of the murray valley encephalitis virus ns methyltransferase domain in complex with sah (monoclinic fo
Source: Murray valley encephalitis virus (stra 51). Organism_taxid: 301478. Strain: mve-1-51, mvev. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2px5
Crystal structure of the murray valley encephalitis virus ns methyltransferase domain in complex with sah (orthorhombic form)
Source: Murray valley encephalitis virus (stra 51). Organism_taxid: 301478. Strain: mve-1-51, mvev. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (265 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2px8
Crystal structure of the murray valley encephalitis virus ns methyltransferase domain in complex with sah and 7m-gtp
Source: Murray valley encephalitis virus (stra 51). Organism_taxid: 301478. Strain: mve-1-51, mvev. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (264 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group MGT is 48.53% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2pxa
Crystal structure of the murray valley encephalitis virus ns methyltransferase domain in complex with sah and gtpg
Source: Murray valley encephalitis virus (stra 51). Organism_taxid: 301478. Strain: mve-1-51, mvev. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (262 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group GTP is 47.06% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2pxc
Crystal structure of the murray valley encephalitis virus ns methyltransferase domain in complex with sam and gtpa
Source: Murray valley encephalitis virus (stra 51). Organism_taxid: 301478. Strain: mve-1-51, mvev. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (263 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group G3A is 51.28% similar to enzyme reactant m(7)G(5')pppR-RNA
2qeq
Crystal structure of kunjin virus ns3 helicase
Source: Kunjin virus (strain mrm61c). Organism_taxid: 11078. Strain: mrm61c. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: part of genome polyprotein
Chains: A, B (415 residues) CATH domains: Unassigned 3.40.50.300
2r29
Neutralization of dengue virus by a serotype cross-reactive antibody elucidated by cryoelectron microscopy and x-ray crystallography
Source: Dengue virus 2 thailand/16681/84. Organism_taxid: 31634. Strain: 16681. Gene: e protein. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Mus musculus. House mouse. Organism_taxid: 10090.
Chain: A (97 residues) CATH domain: 2.60.40.350
2v8o
Structure of the murray valley encephalitis virus RNA helicase to 1.9a resolution
Source: Murray valley encephalitis virus. Organism_taxid: 11079. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: de3. Expression_system_cell_line: plyss
Chain: A (429 residues) CATH domains: Unassigned 3.40.50.300
2vp3
Dc26 mutant of vaccinia virus protein vp39 in complex with s adenosylhomocysteine and m7g(5')pppg
Source: Vaccinia virus. Organism_taxid: 10254. Strain: wr. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group M7G is 42.65% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2whx
A second conformation of the ns3 protease-helicase from dengue virus
Source: Dengue virus 4. Organism_taxid: 11070. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (582 residues) CATH domains: Unassigned Unassigned 3.40.50.300
Bound ligand:   Het Group ADP is 51.43% similar to enzyme product S-adenosylhomocysteine
2wv9
Crystal structure of the ns3 protease-helicase from murray valley encephalitis virus
Source: Murray valley encephalitis virus. Organism_taxid: 301478. Strain: mve-1-51. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (601 residues) CATH domains: Unassigned Unassigned 3.40.50.300
2wzq
Insertion mutant e173gp174 of the ns3 protease-helicase from dengue virus
Source: Dengue virus. Organism_taxid: 12637. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (581 residues) CATH domains: Unassigned Unassigned 3.40.50.300
2yol
West nile virus ns2b-ns3 protease in complex with 3,4- dichlorophenylacetyl-lys-lys-gcma
Source: West nile virus. Organism_taxid: 11082. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold.
Chain: A (212 residues) CATH domain: 2.40.10.120
2z83
Crystal structure of catalytic domain of japanese encephalitis virus ns3 helicase/nucleoside triphosphatase at a resolution 1.8
Source: Japanese encephalitis virus. Organism_taxid: 11072. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (426 residues) CATH domains: Unassigned 3.40.50.300
3e90
West nile vi rus ns2b-ns3protease in complexed with inhibitor naph-kkr-h
Source: West nile virus. Wnv. Organism_taxid: 11082. Strain: wnv ny99-4132. Gene: ns2b-ns3protease. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (47 residues) CATH domain: Unassigned
3eld
Wesselsbron methyltransferase in complex with sinefungin
Source: Wesselsbron virus. Organism_taxid: 164416. Strain: sah-177 99871-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (277 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SFG is 51.43% similar to enzyme product S-adenosylhomocysteine
3elu
Wesselsbron virus methyltransferase in complex with adomet
Source: Wesselsbron virus. Organism_taxid: 164416. Strain: sah-177 99871-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (274 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
3elw
Wesselsbron virus methyltransferase in complex with adomet a
Source: Wesselsbron virus. Organism_taxid: 164416. Strain: sah-177 99871-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group GP3 is 50.00% similar to enzyme reactant m(7)G(5')pppR-RNA
3ely
Wesselsbron virus methyltransferase in complex with adohcy
Source: Wesselsbron virus. Organism_taxid: 164416. Strain: sah-177 99871-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3emb
Wesselsbron virus methyltransferase in complex with adomet a 7megpppg
Source: Wesselsbron virus. Organism_taxid: 164416. Strain: sah-177 99871-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (260 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group GTG is 51.00% similar to enzyme reactant m(7)G(5')pppR-RNA
3emd
Wesselsbron virus methyltransferase in complex with sinefung 7megpppa
Source: Wesselsbron virus. Organism_taxid: 164416. Strain: sah-177 99871-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (259 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group GTA is 42.65% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SFG is 51.43% similar to enzyme product S-adenosylhomocysteine
3er8
Crystal structure of the heterodimeric vaccinia virus mRNA polyadenylate polymerase complex with two fragments of RNA
Source: Vaccinia virus wr. Organism_taxid: 10254. Strain: western reserve / wr. Gene: paps, vacwr095, f9. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: papl, vacwr057, e1l. Synthetic: yes. Synthetic: yes
Chains: A, B (288 residues) CATH domain: 3.40.50.150
3er9
Crystal structure of the heterodimeric vaccinia virus mRNA polyadenylate polymerase complex with uu and 3'-deoxy atp
Source: Vaccinia virus wr. Organism_taxid: 10254. Strain: western reserve / wr. Gene: paps, vacwr095, f9. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: papl, vacwr057, e1l. Synthetic: yes
Chain: A (288 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group 3AT is 44.12% similar to enzyme reactant m(7)G(5')pppR-RNA
3erc
Crystal structure of the heterodimeric vaccinia virus mRNA polyadenylate polymerase with three fragments of RNA and 3'-deoxy atp
Source: Vaccinia virus wr. Organism_taxid: 10254. Strain: western reserve / wr. Gene: paps, vacwr095, f9. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: papl, vacwr057, e1l. Synthetic: yes. Synthetic: yes
Chains: A, B (288 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group 3AT is 44.00% similar to enzyme reactant m(7)G(5')pppR-RNA
3eva
Crystal structure of yellow fever virus methyltransferase co with s-adenosyl-l-homocysteine
Source: Yellow fever virus. Organism_taxid: 11090. Strain: 17d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3evb
Crystal structure of yellow fever virus methyltransferase co with s-adenosyl-l-homocysteine
Source: Yellow fever virus. Organism_taxid: 11090. Strain: 17d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3evc
Crystal structure of gtp complex of yellow fever virus methyltransferase and s-adenosyl-l-homocysteine
Source: Yellow fever virus. Organism_taxid: 11090. Strain: 17d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group GTP is 41.18% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3evd
Crystal structure of gtp complex of yellow fever virus methyltransferase and s-adenosyl-l-homocysteine
Source: Yellow fever virus. Organism_taxid: 11090. Strain: 17d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group GTP is 47.06% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3eve
Crystal structure of gpppa complex of yellow fever virus methyltransferase and s-adenosyl-l-homocysteine
Source: Yellow fever virus. Organism_taxid: 11090. Strain: 17d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group G3A is 51.28% similar to enzyme reactant m(7)G(5')pppR-RNA
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3evf
Crystal structure of me7-gpppa complex of yellow fever virus methyltransferase and s-adenosyl-l-homocysteine
Source: Yellow fever virus. Organism_taxid: 11090. Strain: 17d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3evg
Crystal structure of dengue-2 virus methyltransferase complexed with s-adenosyl-l-homocysteine
Source: Dengue virus 2 16681-pdk53. Organism_taxid: 31635. Strain: 16681. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (257 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3ixy
The pseudo-atomic structure of dengue immature virus in complex with fab fragments of the anti-fusion loop antibody e53
Source: Dengue virus 2. Organism_taxid: 11060. Strain: denv2. Expressed in: aedes albopictus. Expression_system_taxid: 7160. Expression_system_cell_line: c6/36. Mus musculus. Organism_taxid: 10090. Expressed in: escherichia coli.
Chains: A, B, C (390 residues)
3j27
Cryoem structure of dengue virus
Source: Dengue virus 2. Denv-2. Organism_taxid: 11060. Strain: new guinea. Cell_line: mosquito cells c6/36. Cell_line: mosquito cells c6/36
Chains: A, B, C, D, E, F (495 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10
3j2p
Cryoem structure of dengue virus capsid protein heterotetram
Source: Dengue virus 2. Denv-2. Organism_taxid: 11060. Strain: new guinea. Cell_line: mosquito cells c6/36. Cell_line: mosquito cells c6/36
Chains: A, B, C, D (495 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10
3l6p
Crystal structure of dengue virus 1 ns2b/ns3 protease
Source: Dengue virus 1. Organism_taxid: 11053. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (196 residues) CATH domain: 2.40.10.120
3lkw
Crystal structure of dengue virus 1 ns2b/ns3 protease active site mutant
Source: Dengue virus 1. Organism_taxid: 11053. Gene: ns2b/ns3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (211 residues) CATH domain: 2.40.10.120
3mag
Vaccinia methyltransferase vp39 complexed with m3ade and s- adenosylhomocysteine
Source: Vaccinia virus. Organism_taxid: 10245. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3mct
Vaccinia methyltransferase vp39 complexed with m3cyt and s- adenosylhomocysteine
Source: Vaccinia virus. Organism_taxid: 10245. Strain: bl21 (de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3p54
Crystal structure of the japanese encephalitis virus envelop strain sa-14-14-2.
Source: Japanese encephalitis virus. Organism_taxid: 11072. Strain: sa-14-14-2. Gene: envelope protein e. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (404 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10 2.60.40.350
3p8z
Dengue methyltransferase bound to a sam-based inhibitor
Source: Dengue virus 3. Organism_taxid: 11069. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (257 residues) CATH domain: 3.40.50.150
3p97
Dengue 3 ns5 methyltransferase bound to the substrate s-aden methionine
Source: Dengue virus 3. Organism_taxid: 11069. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (256 residues) CATH domain: 3.40.50.150
3u1i
Dengue virus protease covalently bound to a peptide
Source: Dengue virus 3. Denv-3. Organism_taxid: 408693. Strain: singapore/8120/1995. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Chains: A, B, C, D (39 residues)
3u1j
Aprotinin bound to dengue virus protease
Source: Dengue virus 3. Denv-3. Organism_taxid: 408693. Strain: singapore/8120/1995. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B (20 residues)
3uaj
Crystal structure of the envelope glycoprotein ectodomain fr virus serotype 4 in complex with the fab fragment of the ch monoclonal antibody 5h2
Source: Dengue virus 4. Organism_taxid: 11070. Strain: myanmar 1976. Gene: envelope. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Pan troglodytes. Chimpanzee. Organism_taxid: 9598.
Chains: B, A (371 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10 2.60.40.350
3uc0
Crystal structure of domain i of the envelope glycoprotein e from dengue virus serotype 4 in complex with the fab fragme chimpanzee monoclonal antibody 5h2
Source: Dengue virus 4. Organism_taxid: 11070. Strain: myanmar 1976. Gene: envelope. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Pan troglodytes. Chimpanzee. Organism_taxid: 9598.
Chains: A, B (111 residues) CATH domain: 2.60.98.10
3uyp
Crystal structure of the dengue virus serotype 4 envelope pr domain iii in complex with the variable domains of mab 4e11
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Dengue virus 4. Organism_taxid: 11070. Strain: myanmar 1976.
Chain: B (96 residues) CATH domain: 2.60.40.350
3uze
Crystal structure of the dengue virus serotype 3 envelope pr domain iii in complex with the variable domains of mab 4e11
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Dengue virus 3. Organism_taxid: 11069. Strain: thailand/pah881/1988. Gene: e.
Chains: C, D (94 residues) CATH domain: Unassigned
3uzq
Crystal structure of the dengue virus serotype 1 envelope pr domain iii in complex with the variable domains of mab 4e11
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Dengue virus 1. Organism_taxid: 11053. Strain: guiana/fga89/1989.
Chain: B (95 residues) CATH domain: Unassigned
3uzv
Crystal structure of the dengue virus serotype 2 envelope pr domain iii in complex with the variable domains of mab 4e11
Source: Dengue virus 2. Denv-2. Organism_taxid: 11064. Strain: jamaica/1409/1983. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.
Chain: A (97 residues) CATH domain: Unassigned
3vtt
High resolution crystal structure of dengue 3 envelope prote iii (ed3)
Source: Dengue virus type 3. Denv-3. Organism_taxid: 408870. Strain: philippines/h87/1956. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (100 residues) CATH domain: Unassigned
3we1
Crystal structure of dengue 4 envelope protein domain iii (e
Source: Dengue virus type 4. Denv-4. Organism_taxid: 408871. Strain: dominica/814669/1981. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (97 residues) CATH domain: Unassigned
3zko
The structure of "breathing" dengue virus.
Source: Dengue virus 2. Organism_taxid: 11060. Strain: new guinea c
Chains: A, B, C (394 residues)
4al8
Structure of dengue virus diii in complex with fab 2h12
Source: Dengue virus. Organism_taxid: 12637. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Organism_taxid: 9606. Other_details: hybridoma. Other_details: hybridoma
Chain: C (98 residues) CATH domain: Unassigned
4am0
Structure of dengue virus strain 4 diii in complex with fab 2h12
Source: Homo sapiens, mus musculus. Human, house mouse. Organism_taxid: 9606, 10090. Dengue virus. Organism_taxid: 11070. Strain: 4. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: Q, R, S, T (91 residues) CATH domain: Unassigned
4cbf
Near-atomic resolution cryo-em structure of dengue serotype 4 virus
Source: Dengue virus 2. Organism_taxid: 11060. Strain: thailand/ngs-c/1944 (denv-2). Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: c6/36. Dengue virus 4. Organism_taxid: 11070. Strain: sg/06k2270dk1/2005.
Chain: C (495 residues)
4dcg
Vaccinia methyltransferase vp39 mutant d182a complexed with m7g and s-adenosylhomocysteine
Source: Vaccinia virus. Organism_taxid: 10245. Strain: bl21 (de3). Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (291 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4fg0
Structure of the st. Louis encephalitis virus envelope prote fusogenic trimer conformation.
Source: St. Louis encephalitis virus. Organism_taxid: 11080. Strain: st. Louis encephalitis virus, strain ms1-7. Gene: envelope protein e. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (386 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10
4gsx
High resolution structure of dengue virus serotype 1 se cont stem
Source: Dengue virus 1. Denv-1. Organism_taxid: 11059. Strain: wp74. Gene: envelope protein. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (390 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10
4gt0
Structure of dengue virus serotype 1 se containing stem to r
Source: Dengue virus 1. Denv-1. Organism_taxid: 11059. Strain: wp74. Gene: envelope protein. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (390 residues) CATH domains: 2.60.98.10 3.30.67.10 3.30.387.10
4hdg
Crystal structure of viral rdrp in complex with gtp
Source: Japanese encephalitis virus. Organism_taxid: 11072. Strain: p20778. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (612 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group GTP is 47.06% similar to enzyme reactant m(7)G(5')pppR-RNA
4hdh
Crystal structure of viral rdrp in complex with atp
Source: Japanese encephalitis virus. Organism_taxid: 11072. Strain: p20778. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (613 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned
Bound ligand:   Het Group ATP is 46.15% similar to enzyme product S-adenosylhomocysteine
4k6m
Crystal structure of the full-length japanese encephalitis v
Source: Japanese encephalitis virus. Organism_taxid: 11072. Strain: at31. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (888 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4mtp
Rdrp from japanesese encephalitis virus
Source: Japanese encephalitis virus. Organism_taxid: 11072. Gene: ns5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (591 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned
4n48
Cap-specific mRNA (nucleoside-2'-o-)-methyltransferase 1 pro complex with capped RNA fragment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ftsjd2, kiaa0082, mtr1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic RNA
Chains: A, B (401 residues)
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group MGT is 47.06% similar to enzyme reactant m(7)G(5')pppR-RNA
4n49
Cap-specific mRNA (nucleoside-2'-o-)-methyltransferase 1 pro complex with m7gpppg and sam
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ftsjd2, kiaa0082, mtr1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (402 residues)
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group MGT is 47.06% similar to enzyme reactant m(7)G(5')pppR-RNA
4n4a
Cystal structure of cap-specific mRNA (nucleoside-2'-o-)- methyltransferase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ftsjd2, kiaa0082, mtr1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (398 residues)
4o6b
Dengue type2 virus non-structural protein 1 (ns1) form 1 cry
Source: Dengue virus 2. Denv-2. Organism_taxid: 31634. Strain: thailand/16681/1984. Gene: ns1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (319 residues)