_EC 2.1.1.28 Phenylethanolamine N-methyltransferase. 33 PDB entries  
EC 2.-.-.- Transferases. [15,100 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,417 PDB entries]
EC 2.1.1.- Methyltransferases. [1,143 PDB entries]
EC 2.1.1.28 Phenylethanolamine N-methyltransferase. [33 PDB entries]    
1hnn

Pathway: Dopa Biosynthesis
Reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
 


S-adenosyl-L-methionine
+
phenylethanolamine
=
S-adenosyl-L-homocysteine
+
N-methylphenylethanolamine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Noradrenaline N-methyltransferase.
Comments: Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 33 PDB entries in enzyme class E.C.2.1.1.28

  PDB code Protein
1hnn
Crystal structure of human pnmt complexed with sk&f 29661 and adohcy(sah)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group SKF is 66.00% similar to enzyme product N-methylphenylethanolamine
1n7i
The structure of phenylethanolamine n-methyltransferase in complex with s-adenosylhomocysteine and the inhibitor ly134046
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt or pent. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group LY1 is 71.00% similar to enzyme product N-methylphenylethanolamine
1n7j
The structure of phenylethanolamine n-methyltransferase in complex with s-adenosylhomocysteine and an iodinated inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt or pent. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group IDI is 83.00% similar to enzyme product N-methylphenylethanolamine
1yz3
Structure of human pnmt complexed with cofactor product adohcy and inhibitor sk&f 64139
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (263 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group SKA is 76.00% similar to enzyme product N-methylphenylethanolamine
2an3
Structure of pnmt with s-adenosyl-l-homocysteine and the sem analogue acceptor substrate cis-(1r,2s)-2-amino-1-tetralol.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group CTL is 83.33% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2an4
Structure of pnmt complexed with s-adenosyl-l-homocysteine a acceptor substrate octopamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group OTR is 90.91% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2an5
Structure of human pnmt complexed with s-adenosyl- homocysteine and an inhibitor, trans-(1s,2s)-2-amino-1- tetralol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group TTL is 83.00% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2g70
Structure of human pnmt in complex with inhibitor 3-hydroxym nitro-thiq and adomet (sam)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
  Het Group HNT is 62.50% similar to enzyme product N-methylphenylethanolamine
2g71
Structure of hpnmt with inhibitor 3-fluoromethyl-7-trifluoro thiq and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (261 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group FTS is 43.48% similar to enzyme product N-methylphenylethanolamine
2g8n
Structure of hpnmt with inhibitor 3-hydroxymethyl-7-(n-4- chlorophenylaminosulfonyl)-thiq and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group F83 is 41.67% similar to enzyme product N-methylphenylethanolamine
2obf
Structure of k57a hpnmt with inhibitor 3-hydroxymethyl-7-(n- chlorophenylaminosulfonyl)-thiq and adohcy (sah)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group F83 is 41.67% similar to enzyme product N-methylphenylethanolamine
2onz
Structure of k57a hpnmt with inhibitor 7-(n-4- chlorophenylaminosulfonyl)-thiq and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group TMJ is 45.45% similar to enzyme product N-methylphenylethanolamine
3hca
Crystal structure of e185q hpnmt in complex with octopamine and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (258 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group OTR is 90.00% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3hcb
Crystal structure of hpnmt in complex with noradrenochrome and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group LT2 is 83.00% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3hcc
Crystal structure of hpnmt in complex with anti-9-amino-5- (trifluromethyl) benzonorbornene and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (259 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group LT3 is 52.00% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3hcd
Crystal structure of hpnmt in complex with noradrenaline and
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group LNR is 83.33% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3hce
Crystal structure of e185d hpnmt in complex with octopamine and adohcy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group OTR is 90.00% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3kpj
Crystal structure of hpnmt in complex adohcy and bound phosp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pent, pnmt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3kpu
Crystal structure of hpnmt in complex adohcy and 4-quinolino
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group ES1 is 83.00% similar to enzyme product N-methylphenylethanolamine
3kpw
Crystal structure of hpnmt in complex adohcy and 1-aminoisoq
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group 1SQ is 83.00% similar to enzyme product N-methylphenylethanolamine
3kpy
Crystal structure of hpnmt in complex adohcy and 6-chlorooxi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group ES2 is 75.00% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3kqm
Crystal structure of hpnmt in complex adohcy and 4-bromo-1h-
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3kqp
Crystal structure of hpnmt in complex adohcy and 6-aminoquin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group ES5 is 83.00% similar to enzyme product N-methylphenylethanolamine
3kqq
Crystal structure of hpnmt in complex adohcy and 2-hydroxyni acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group ES6 is 53.00% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
3kqt
Crystal structure of hpnmt in complex adohcy and 2-amino-1- methylbenzimidazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group ES7 is 57.00% similar to enzyme product N-methylphenylethanolamine
3kqv
Crystal structure of hpnmt in complex adohcy and formanilide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group FAN is 66.00% similar to enzyme product N-methylphenylethanolamine
3kqw
Crystal structure of hpnmt in complex adohcy and 5-chloroben
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group ES9 is 61.00% similar to enzyme product N-methylphenylethanolamine
3kqy
Crystal structure of hpnmt in complex adohcy and 2-amino-1h- benzo[d]imidazol-7-ol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group ES0 is 69.00% similar to enzyme product N-methylphenylethanolamine
3kr1
Crystal structure of hpnmt in complex adohcy and 5-chloro-1h benzo[d]imidazol-2-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group VGD is 57.00% similar to enzyme product N-methylphenylethanolamine
3kr2
Crystal structure of hpnmt in complex adohcy and 5-fluoro-1h benzo[d]imidazol-2-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pent, pnmt. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
  Het Group ET2 is 57.00% similar to enzyme product N-methylphenylethanolamine
4dm3
Crystal structure of human pnmt in complex adohcy, resorcino imidazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (257 residues) CATH domain: 3.40.50.150
Bound ligands:   Het Group RCO is 63.64% similar to enzyme reactant phenylethanolamine
  Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4mik
Crystal structure of hpnmt in complex with bisubstrate inhib 3r,4s,5s)-2-(6-amino-9h-purin-9-yl)-5-(((2-(((7-nitro-1,2,3 tetrahydroisoquinolin-3-yl)methyl)amino)ethyl)thio)methyl) tetrahydrofuran-3,4-diol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (255 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group JIL is 51.22% similar to enzyme product S-adenosylhomocysteine
4mq4
Crystal structure of hpnmt in complex with bisubstrate inhib ((((2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4- dihydroxytetrahydrofuran-2-yl)methyl)thio)propyl)-1,2,3,4- tetrahydroisoquinoline-3-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pnmt, pent. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (264 residues) CATH domain: 3.40.50.150
Bound ligand:   Het Group 2D5 is 60.53% similar to enzyme product S-adenosylhomocysteine