_EC 2.1.1.233 [Phosphatase 2A protein]-leucine-carboxy methyltransferase. 9 PDB entries  
EC 2.-.-.- Transferases. [17,766 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,721 PDB entries]
EC 2.1.1.- Methyltransferases. [1,372 PDB entries]
EC 2.1.1.233 [Phosphatase 2A protein]-leucine-carboxy methyltransferase. [9 PDB entries]    
1rjd

Reaction: S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl- L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
 


S-adenosyl-L-methionine
+ [phosphatase 2A protein]-leucine
=
S-adenosyl- L-homocysteine
+ [phosphatase 2A protein]-leucine methyl ester
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Leucine carboxy methyltransferase-1.
Comments: Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolyzed by Ec 3.1.1.89. Occurs mainly in the cytoplasm, Golgi region and late endosomes.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 9 PDB entries in enzyme class E.C.2.1.1.233

  PDB code Protein
1rjd
Structure of ppm1, a leucine carboxy methyltransferase involved in the regulation of protein phosphatase 2a activity
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ppm1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (328 residues) CATH domain: 3.40.50.150
1rje
Structure of ppm1, a leucine carboxy methyltransferase involved in the regulation of protein phosphatase 2a activity
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ppm1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (328 residues) CATH domain: 3.40.50.150
1rjf
Structure of ppm1, a leucine carboxy methyltransferase invol regulation of protein phosphatase 2a activity
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ppm1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (321 residues) CATH domain: 3.40.50.150
1rjg
Structure of ppm1, a leucine carboxy methyltransferase involved in the regulation of protein phosphatase 2a activity
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ppm1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (291 residues) CATH domain: 3.40.50.150
2ob1
Ppm1 with 1,8-ans
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ppm1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (319 residues) CATH domain: 3.40.50.150
2ob2
Ppm1 in the absence of 1,8-ans (cf 1jd)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ppm1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (327 residues) CATH domain: 3.40.50.150
3iei
Crystal structure of human leucine carboxylmethyltransferase complex with s-adenosyl homocysteine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cgi-68, lcmt, lcmt-1, lcmt1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (310 residues) CATH domain: 3.40.50.150
3o7w
The crystal structure of human leucine carboxyl methyltransf
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lcmt1, lcmt, cgi-68. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (282 residues) CATH domain: 3.40.50.150
3p71
Crystal structure of the complex of lcmt-1 and pp2a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cgi-68, lcmt, lcmt1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: ppp2ca. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7101.
Chain: T (315 residues) CATH domain: 3.40.50.150