_EC 2.1.1.228 tRNA (guanine(37)-N(1))-methyltransferase. 21 PDB entries  
EC 2.-.-.- Transferases. [18,188 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,730 PDB entries]
EC 2.1.1.- Methyltransferases. [1,400 PDB entries]
EC 2.1.1.228 tRNA (guanine(37)-N(1))-methyltransferase. [21 PDB entries]    
1oy5

Reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
 


S-adenosyl-L-methionine
+ guanine(37) in tRNA
=
S-adenosyl-L-homocysteine
+ N(1)-methylguanine(37) in tRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Transfer Rna (m(1)G(37)) methyltransferase. tRNA (m(1)G(37)) methyltransferase. tRNA-(N(1)G37) methyltransferase.
Comments: This enzyme is important for the maintenance of the correct reading frame during translation. Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. Formerly Ec 2.1.1.31.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 21 PDB entries in enzyme class E.C.2.1.1.228

  PDB code Protein
1oy5
Crystal structure of tRNA (m1g37) methyltransferase from aqu aeolicus
Source: Aquifex aeolicus. Organism_taxid: 63363. Gene: trmd or aq_1489. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (218 residues) CATH domains: 3.40.1280.10 1.10.1270.20
1p9p
The crystal structure of a m1g37 tRNA methyltransferase, trm
Source: Escherichia coli. Organism_taxid: 562,217992,83334,623. Strain: o6, o157:h7. Gene: trmd or b2607 or c3128 or z3901 or ecs3470 or sf2667. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (235 residues) CATH domains: 3.40.1280.10 1.10.1270.20
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1uaj
Crystal structure of tRNA(m1g37)methyltransferase: insight i recognition
Source: Haemophilus influenzae. Organism_taxid: 727. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (241 residues) CATH domains: 3.40.1280.10 1.10.1270.20
1uak
Crystal structure of tRNA(m1g37)methyltransferase: insight i recognition
Source: Haemophilus influenzae. Organism_taxid: 727. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (243 residues) CATH domains: 3.40.1280.10 1.10.1270.20
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine
1ual
Crystal structure of tRNA(m1g37)methyltransferase: insight i recognition
Source: Haemophilus influenzae. Organism_taxid: 727. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (243 residues) CATH domains: 3.40.1280.10 1.10.1270.20
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
1uam
Crystal structure of tRNA(m1g37)methyltransferase: insight i recognition
Source: Haemophilus influenzae. Organism_taxid: 727. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (250 residues) CATH domains: 3.40.1280.10 1.10.1270.20
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
2yx1
Crystal structure of m.Jannaschii tRNA m1g37 methyltransfera
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domains: Unassigned Unassigned 3.40.50.150
Bound ligand:   Het Group SFG is 51.43% similar to enzyme product S-adenosylhomocysteine
2zzm
The complex structure of atrm5 and trnaleu
Source: Methanocaldococcus jannaschii. Methanococcus jannaschii. Organism_taxid: 2190. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthesized in vitro with the recombinant RNA polymerase of t7 phage
Chain: A (333 residues) CATH domains: Unassigned Unassigned 3.40.50.150
2zzn
The complex structure of atrm5 and trnacys
Source: Methanocaldococcus jannaschii. Methanococcus jannaschii. Organism_taxid: 2190. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthesized in vitro with the recombinant RNA polymerase of t7 phage
Chains: A, B (336 residues) CATH domains: Unassigned Unassigned 3.40.50.150
3axz
Crystal structure of haemophilus influenzae trmd in complex adenosine
Source: Haemophilus influenzae. Organism_taxid: 71421. Strain: kw20. Gene: hi_0202, trmd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (241 residues) CATH domains: 3.40.1280.10 1.10.1270.20
Bound ligand:   Het Group ADN is 66.67% similar to enzyme product S-adenosylhomocysteine
3ay0
Crystal structure of methanocaldococcus jannaschii trm5 in c with adenosine
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Gene: mj0883, trm5. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (320 residues) CATH domains: Unassigned Unassigned 3.40.50.150
3ief
Crystal structure of tRNA guanine-n1-methyltransferase from bartonella henselae using mpcs.
Source: Bartonella henselae. Rochalimaea henselae. Organism_taxid: 38323. Strain: houston-1. Gene: trmd, bh15820. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (224 residues) CATH domains: 3.40.1280.10 1.10.1270.20
3knu
Crystal structure of tRNA (guanine-n1)-methyltransferase fro anaplasma phagocytophilum
Source: Anaplasma phagocytophilum. Organism_taxid: 212042. Strain: hz. Gene: trmd, aph_1267. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (192 residues) CATH domain: 3.40.1280.10
3ky7
2.35 angstrom resolution crystal structure of a putative trn (guanine-7-)-methyltransferase (trmd) from staphylococcus a subsp. Aureus mrsa252
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 282458. Strain: mrsa252. Gene: sar1216, trmd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (229 residues) CATH domains: 3.40.1280.10 1.10.1270.20
3quv
Crystal structure of a tRNA-guanine-n1-methyltransferase fro mycobacterium abscessus
Source: Mycobacterium abscessus. Organism_taxid: 561007. Strain: dsm 44196. Atcc: 19977. Gene: mab_3226c, trmd
Chains: A, B (216 residues) CATH domains: 3.40.1280.10 1.10.1270.20
4h3y
Crystal structure of an asymmetric dimer of a tRNA (guanine- methyltransferase from burkholderia phymatum bound to s-ade homocystein in one half-site
Source: Burkholderia phymatum. Organism_taxid: 391038. Strain: dsm 17167 stm815. Gene: bphy_0771, trmd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (255 residues) CATH domains: 3.40.1280.10 1.10.1270.20
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4h3z
Crystal structure of a symmetric dimer of a tRNA (guanine-(n methyltransferase from burkholderia phymatum bound to s-ade homocystein in both half-sites
Source: Burkholderia phymatum. Organism_taxid: 391038. Strain: dsm 17167 stm815. Gene: bphy_0771, trmd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (249 residues) CATH domains: 3.40.1280.10 1.10.1270.20
Bound ligand:   Het Group SAH corresponds to enzyme product S-adenosylhomocysteine
4ig6
Crystal structure of a tRNA (guanine-n1)-methyltransferase f anaplasma phagocytophilum bound to s-adenosylhomocysteine
Source: Anaplasma phagocytophilum. Organism_taxid: 212042. Strain: hz. Gene: aph_1267, trmd. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (223 residues) CATH domains: 3.40.1280.10 1.10.1270.20
4mcb
H.Influenzae trmd in complex with n-(4-{[(1h-imidazol-2-ylme amino]methyl}benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidi carboxamide
Source: Haemophilus influenzae. Organism_taxid: 71421. Strain: atcc51907. Gene: hi_0202, trmd. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (205 residues) CATH domains: 3.40.1280.10 1.10.1270.20
4mcc
Hintrmd in complex with n-[4-(aminomethyl)benzyl]-4-oxo-3,4- dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Source: Haemophilus influenzae. Organism_taxid: 71421. Strain: atcc51907. Gene: hi_0202, trmd. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (206 residues) CATH domains: 3.40.1280.10 1.10.1270.20
4mcd
Hintrmd in complex with 5-phenylthieno[2,3-d]pyrimidin-4(3h)
Source: Haemophilus influenzae rd kw20. Organism_taxid: 71421. Strain: atcc51907. Gene: hi_0202, trmd. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (237 residues) CATH domains: 3.40.1280.10 1.10.1270.20