_EC 2.1.1.208 23S rRNA (uridine(2479)-2'-O)-methyltransferase. 2 PDB entries  
EC 2.-.-.- Transferases. [18,241 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,718 PDB entries]
EC 2.1.1.- Methyltransferases. [1,387 PDB entries]
EC 2.1.1.208 23S rRNA (uridine(2479)-2'-O)-methyltransferase. [2 PDB entries]    
1x7o

Reaction: S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methyluridine(2479) in 23S rRNA.
 


S-adenosyl-L-methionine
+ uridine(2479) in 23S rRNA
=
S-adenosyl-L- homocysteine
+ 2'-O-methyluridine(2479) in 23S rRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine(2479)-2'-O)- methyltransferase and Ec 2.1.1.209 whose actions confer avilamycin resistance to the Rna.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.2.1.1.208

  PDB code Protein
1x7o
Crystal structure of the spou methyltransferase avirb from streptomyces viridochromogenes
Source: Streptomyces viridochromogenes. Organism_taxid: 1938. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (267 residues) CATH domains: 3.30.1330.30 3.40.1280.10
1x7p
Crystal structure of the spou methyltransferase avirb from streptomyces viridochromogenes in complex with the cofactor
Source: Streptomyces viridochromogenes. Organism_taxid: 1938. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (265 residues) CATH domains: 3.30.1330.30 3.40.1280.10
Bound ligand:   Het Group SAM corresponds to enzyme reactant S-adenosyl-L-methionine