_EC 2.1.1.202 Multisite-specific tRNA:(cytosine-C(5))-methyltransferase. 0 PDB entries  
EC 2.-.-.- Transferases. [19,022 PDB entries]
EC 2.1.-.- Transferring one-carbon groups. [1,783 PDB entries]
EC 2.1.1.- Methyltransferases. [1,448 PDB entries]
EC 2.1.1.202 Multisite-specific tRNA:(cytosine-C(5))-methyltransferase. [-]    

Reaction: (1) S-adenosyl-L-methionine + cytosine(34) in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine(34) in tRNA precursor. (2) S-adenosyl-L-methionine + cytosine(40) in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine(40) in tRNA precursor. (3) S-adenosyl-L-methionine + cytosine(48) in tRNA = S-adenosyl-L- homocysteine + 5-methylcytosine(48) in tRNA. (4) S-adenosyl-L-methionine + cytosine(49) in tRNA = S-adenosyl-L- homocysteine + 5-methylcytosine(49) in tRNA.
 


S-adenosyl-L-methionine
+ cytosine(34) in tRNA precursor
=
S-adenosyl-L-homocysteine
+ 5-methylcytosine(34) in tRNA precursor

S-adenosyl-L-methionine
+ cytosine(40) in tRNA precursor
=
S-adenosyl-L-homocysteine
+ 5-methylcytosine(40) in tRNA precursor

S-adenosyl-L-methionine
+ cytosine(48) in tRNA
=
S-adenosyl-L- homocysteine
+ 5-methylcytosine(48) in tRNA

S-adenosyl-L-methionine
+ cytosine(49) in tRNA
=
S-adenosyl-L- homocysteine
+ 5-methylcytosine(49) in tRNA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: The enzyme from Saccharomyces cerevisiae is responsible for complete 5-methylcytosine methylations of yeast tRNA. The incidence of modification depends on the cytosine position in tRNA. At positions 34 and 40, 5-methylcytosine is found only in two yeast tRNAs (tRNA(Leu)(CUA) and tRNA(Phe)(GAA), respectively), whereas most other elongator yeast tRNAs bear either 5-methylcytosine(48) or 5-methylcytosine(49), but never both in the same tRNA molecule. The formation of 5-methylcytosine(34) and 5-methylcytosine(40) is a strictly intron-dependent process, whereas the formation of
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.2.1.1.202